A5035192769- Microbial Metabolic Engineering and Bioproduction
- Genetics, Aging, and Longevity in Model Organisms
- Agricultural pest management studies
- Fungal and yeast genetics research
- Trace Elements in Health
- Educational Methods and Analysis
- Amyotrophic Lateral Sclerosis Research
- Diet and metabolism studies
- Phytase and its Applications
- Metabolism, Diabetes, and Cancer
- Botanical Research and Chemistry
- RNA Research and Splicing
- Values and Moral Education
- biodegradable polymer synthesis and properties
- Plant Micronutrient Interactions and Effects
- Mitochondrial Function and Pathology
- Aluminum toxicity and tolerance in plants and animals
- Turkish Literature and Culture
- Biotin and Related Studies
- Media Discourse and Social Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Heart Rate Variability and Autonomic Control
- GABA and Rice Research
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
Istanbul University
2007-2024
Legumes are indispensable for human diet in respect to their valuable and nutritive bioactive molecules. derivative foodstuffs rich fiber, proteins, vitamins some phytochemicals, which exhibit important biological activities. Due remarkable molecular content, they receiving great attention by researchers. Recent developments genomics bioinformatics led cumulative data about legume genomes. These could provide information accelerate breeding develop new traits biofortification. The main focus...
Abstract The antiaging properties of metformin used for the treatment type-2 diabetes mellitus have been studied extensively, but there is more to discover regarding underlying mechanisms. Here, we show that significantly prolongs chronological lifespan (CLS) Schizosaccharomyces pombe through mechanisms similar those observed in mammalian cells and other model organisms. While presence medium caused an increase carbohydrate consumption ATP production, it reduced reactive oxygen species...
Abstract Hyperglycaemia, hyperlipidaemia, hypertension and obesity are the main risk factors affecting development prognosis of ischaemic heart disease, which is still an important cause death today. In our study, male Sprague–Dawley rats were fed either a standard diet (SD) or high fat carbohydrate (HF‐HCD) for 8 weeks streptozotocin (STZ) was injected at seventh week feeding period. one set rats, mixture prebiotic probiotics (synbiotic, SYN) administered by gavage starting from beginning...
Abstract Zinc is a metal which cofactor in many enzymes and structural element zinc finger motifs those are important relation between DNA regulator proteins. Little known about uptake, distribution, toxicity detoxification of ions cells. In this study, levels have been compared wild type Cu/Zn superoxide dismutase mutant ( sod1Δ ) cells the fission yeast Schizosaccharomyces pombe . We evaluated toxic zinc, total content, lipid peroxidation catalase activities for both strains were grown...
Because of its specific electrochemical properties, copper is an essential heavy metal for living organisms.As with other metals, high levels can provoke damage.We examined gene expression under stress in wild-type fission yeast (Schizosaccharomyces pombe) through differential display.After the EC 50 concentration CuSO 4 was determined as µM, total RNA isolated from cells treated or not copper.The level SPCC1682.13,ppk1, SPBC2F12.05c,and adg2 genes increased significantly stress.Considering...
While calorie restriction is the most used experimental intervention to increase lifespan in numerous model organisms, increasing evidence suggests that excess glucose leads decreased various organisms. To fully understand molecular basis of pro-aging effect glucose, it still important discover genetic interactions, gene expression patterns, and responses depending on availability. Here, we compared profiles Schizosaccharomyces pombe mid-log-phase cells grown three different Synthetic...
Cultivation of microorganisms in ideal laboratory conditions seperates them from their natural and isolates microbial world, especially competitors. With traditional pure culture-oriented cultuvation techniques, interactions mediated by small molecules are not taken into account, resulting the precise nature being largely unknown. Co-culture systems which two or more different cell populations grown together. In this way, studies on between can be made synthetic that observed provided. these...
Complex human diseases such as metabolic disorders, cancer, neurodegenerative diseases, and mitochondrial dysfunctions arise from the biochemical or genetic defects in various cellular processes. Therefore, it is important to understand which processes are affected by impairment. Because genome-wide screening of mutant collections (haploid/diploid deletion library) provides clues for understanding conserved biological finding potential target genes, we screened haploid collection...
Aim: This study aimed to measure the effects of Scilla autumnalis extracts which might act as potential plant based chemotherapeutic, on U87 glioblastoma cell line. Material and Method: Cytotoxicity assays were performed by determining viability samples with MTT (3 -(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Gene expression levels glucose transporter 1 (GLUT1), Glucose 3 (GLUT3), 4 (GLUT4), Hexokinase (HK1) 2 (HK2), multidrug resistance1 (MDR1), Cytochrome P450 Family...