A5089106577- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Electron Spin Resonance Studies
- Intensive Care Unit Cognitive Disorders
- Tannin, Tannase and Anticancer Activities
- Sperm and Testicular Function
- Lung Cancer Treatments and Mutations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell death mechanisms and regulation
- Healthcare and Venom Research
- Chronic Myeloid Leukemia Treatments
- Toxin Mechanisms and Immunotoxins
- Renal Diseases and Glomerulopathies
- Synthesis and biological activity
- Molecular Biology Techniques and Applications
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Plant-Derived Bioactive Compounds
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- Nuts composition and effects
- Ion Channels and Receptors
Istanbul University-Cerrahpaşa
2020-2024
Istanbul University
2017-2023
Donkey milk and donkey kefir exhibit antiproliferative, antimutagenic antibacterial effects. We investigated the effects of on oxidative stress, apoptosis proliferation in Ehrlich ascites carcinoma (EAC) mice. Thirty-four adult male Swiss albino mice were divided into four groups as follows: group 1, administered 0.5 ml water; 2, water + EAC cells; 3, 4, cells. introduced 2.5 x 106 cells each animal by subcutaneous injection. Tap water, gavage for 10 days. Animals sacrificed day 11. After...
Resveratrol is a polyphenolic compound which found in many nutrients including grapes, peanuts, raspberries, and apples.Anti-proliferative, anti-angiogenic apoptotic effects of resveratrol have been shown on various cancer cells.Doxorubicin considered as one the most effective anticancer agents reveals its antitumor activity by induction apoptosis inhibition angiogenesis.Our study reports for first time potent ability combination with doxorubicin to inhibit angiogenesis vitro vivo.The...
The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance anti-angiogenic therapy.The cytotoxic effect doxorubicin (0.1-1 μM), (0.25-32 μM) and their combination were investigated by employing ATP assay in human umbilical vein endothelial cells (HUVECs). was also measured tube formation on Matrigel. activities (2.5 μg/pellet) (15 μg/pellet), combination, standards (50 tested vivo the chick embryo...
Combined use of a chemotherapeutic agent and an autophagy inhibitor is novel cancer treatment strategy. We investigated the effects chloroquine (CQ) on lung pathology caused by both solid Ehrlich ascites carcinoma (EAC) doxorubicin (DXR). A control group eight experimental groups adult female mice were inoculated subcutaneously with 2.5 × 106 EAC cells. DXR (1.5 mg/kg 3 mg/kg) CQ (25 50 alone or in combination injected intraperitoneally days 2, 7 12 following inoculation Lung tissue samples...
The objective of the present study was to examine effects two different transport temperature (37°C vs 4°C) and cold storage ovaries for 24 h on cumulus cell apoptosis maturation rates cat oocytes in vitro.Ovaries were collected from 15 ovariohysterectomized domestic cats maintained transported laboratory phosphate buffer saline at 37°C 4°C.In order determine storing time, some 4°C stored same h.Selected oocyte complexes (COCs) matured 48 38°C four-well petri dishes containing 500 μL...
Rhus coriaria (sumac) naturally grows worldwide and contains many phytochemicals.Tannic acid is frequently used for treating medical conditions.The aim of this study to determine the synergistic effects methanolic acetonic extracts coriaria's from unriped fruits in combination with tannic on angiogenesis by using Chick Chorioallantoic Membrane (CAM) assay.The methanol acetone Sumac (MES AES, respectively, at a final concentration 5 mg/mL both) (Tan 1.25 mg/mL) alone or were examined their...
Introduction: Angiogenesis is involved in many physiological and pathological conditions including cancer. A number of TRP channels induce angiogenesis, promote cell proliferation or apoptosis several types human cancers. Therefore, may be considered potential pharmacological targets for therapeutic options disorders caused by insufficient angiogenesis aberrant vascularization. Aims: This study aimed to comparatively investigate vitro anti-cancer vivo anti-angiogenic effects TRPC blockers...
<title>Abstract</title> Sevoflurane, a common pediatric anesthetic, has been linked to neurodegeneration, raising safety concerns. This study explored N-acetylcysteine's protective potential against sevoflurane-induced neurotoxicity in rat hippocampi. Four groups were examined: Control: Received 6 hours of 3 l/min gas (air and 30% O2) intraperitoneal saline. NAC: 150mg/kg NAC intraperitoneally. Sev: Exposed 3% sevoflurane. Sev+NAC: gas, sevoflurane, NAC. Protein levels NRF-2, NLRP3, IL-1β,...