A5029183291- Metal complexes synthesis and properties
- Morinda citrifolia extract uses
- Cancer Mechanisms and Therapy
- Electron Spin Resonance Studies
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Sperm and Testicular Function
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Tannin, Tannase and Anticancer Activities
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Diet and metabolism studies
- Nuts composition and effects
- Sulfur Compounds in Biology
- Melanoma and MAPK Pathways
- Lipid metabolism and biosynthesis
- Regulation of Appetite and Obesity
- PI3K/AKT/mTOR signaling in cancer
Istanbul University-Cerrahpaşa
2019-2024
Istanbul University
2014-2023
Acıbadem University
2023
Weatherford College
2017
Donkey milk and donkey kefir exhibit antiproliferative, antimutagenic antibacterial effects. We investigated the effects of on oxidative stress, apoptosis proliferation in Ehrlich ascites carcinoma (EAC) mice. Thirty-four adult male Swiss albino mice were divided into four groups as follows: group 1, administered 0.5 ml water; 2, water + EAC cells; 3, 4, cells. introduced 2.5 x 106 cells each animal by subcutaneous injection. Tap water, gavage for 10 days. Animals sacrificed day 11. After...
Abstract This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product noni ( Morinda citrifolia ) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control three experimental groups were formed. Experimental administered juice alone, juice+carrageenan, carrageenan alone. Oxidant capacity determined by d-ROMs test BAP test, respectively. Plasma concentrations endothelin-1 leptin measured ELISA. Measurements performed at...
Resveratrol is a polyphenolic compound which found in many nutrients including grapes, peanuts, raspberries, and apples.Anti-proliferative, anti-angiogenic apoptotic effects of resveratrol have been shown on various cancer cells.Doxorubicin considered as one the most effective anticancer agents reveals its antitumor activity by induction apoptosis inhibition angiogenesis.Our study reports for first time potent ability combination with doxorubicin to inhibit angiogenesis vitro vivo.The...
The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance anti-angiogenic therapy.The cytotoxic effect doxorubicin (0.1-1 μM), (0.25-32 μM) and their combination were investigated by employing ATP assay in human umbilical vein endothelial cells (HUVECs). was also measured tube formation on Matrigel. activities (2.5 μg/pellet) (15 μg/pellet), combination, standards (50 tested vivo the chick embryo...
Spirulina platensis is a microalga that may be source of antioxidants can reduce body fat deposition. Consumption high diet produces elevated blood lipid levels, inflammation and apoptosis. We investigated the possible effects S. on profile, liver apoptosis in rats fed diet. Sixty-four young male were divided into eight equal groups. The control group was basic experimental groups for 60 days prepared by mixing variable amounts 43% vegetable oil 10% cholesterol with or without 3% mixed basal...
Background/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H<sub>2</sub>S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. Materials Methods: Rat hearts were studied with Langendorff technique using H<sub>2</sub>S donor sodium hydrosulfide (NaHS, 40 μM) cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) administered before...
Abstract Ghrelin is a peptide hormone which plays important role in maintaining growth release and energy homeostasis vertebrates. Spirulina platensis (SP) has antioxidant hypolipidemic effects due to its ingredients. In this study we aimed investigate the of SP on testicular structure relation between ghrelin testosterone testis rats fed high fat diet (HFD). Sixty four young adult male were used divided 8 equal groups. Experimental groups received addition 10% cholesterol (CHL), 43%...
Combined use of a chemotherapeutic agent and an autophagy inhibitor is novel cancer treatment strategy. We investigated the effects chloroquine (CQ) on lung pathology caused by both solid Ehrlich ascites carcinoma (EAC) doxorubicin (DXR). A control group eight experimental groups adult female mice were inoculated subcutaneously with 2.5 × 106 EAC cells. DXR (1.5 mg/kg 3 mg/kg) CQ (25 50 alone or in combination injected intraperitoneally days 2, 7 12 following inoculation Lung tissue samples...
The objective of the present study was to examine effects two different transport temperature (37°C vs 4°C) and cold storage ovaries for 24 h on cumulus cell apoptosis maturation rates cat oocytes in vitro.Ovaries were collected from 15 ovariohysterectomized domestic cats maintained transported laboratory phosphate buffer saline at 37°C 4°C.In order determine storing time, some 4°C stored same h.Selected oocyte complexes (COCs) matured 48 38°C four-well petri dishes containing 500 μL...