A5053825532- Barrier Structure and Function Studies
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal and fetal brain pathology
- Medical Imaging Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Drug-Induced Hepatotoxicity and Protection
- Curcumin's Biomedical Applications
- Pregnancy and preeclampsia studies
- S100 Proteins and Annexins
- Agricultural and Rural Development Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Connexins and lens biology
- Immunotoxicology and immune responses
- Neurosurgical Procedures and Complications
- Thermal Regulation in Medicine
- Neurological and metabolic disorders
- Pesticide Exposure and Toxicity
Istanbul University
2006-2024
In this study, we examined the effects of magnesium sulfate administration on brain edema and blood–brain barrier breakdown after experimental traumatic injury in rats. Seventy-one adult male Sprague-Dawley rats were anesthetized, closed head trauma was induced by allowing a 450-g weight to fall from 2-m height onto metallic disk fixed intact skull. Sixty-eight surviving randomly assigned receive an intraperitoneal bolus either 750 μmol/kg (group 4; n = 30) or 1 mL saline 2; 30 minutes...
Magnesium probably protects brain tissue against the effects of cerebral ischemia, injury and stroke through its actions as a calcium antagonist inhibitor excitatory amino acids. The magnesium sulfate on cerebrovascular permeability to dye, Evans blue, were studied during insulin-induced hypoglycemia with hypothermia in rats. Hypoglycemia was induced by an intramuscular injection insulin. After giving insulin, each animal received MgSO4 (270 mg/kg) ip, followed 27 mg/kg dose every 20 min for...
Hypercholesterolemia and/or hypertension impair endothelial function in peripheral vasculature; however, their impact on cells of brain microvessels is unclear. We investigated the effects hypercholesterolemia integrity blood–brain barrier (BBB) and activity astrocytes during Nω-nitro-L-arginine methyl ester (L-NAME) followed by angiotensin (ANG) II. found significant decreases superoxide dismutase levels with all treatments except ANG II L-NAME plus II, catalase concentrations cholesterol...
Magnesium probably protects brain tissue against the effects of cerebral ischemia, injury and stroke through its actions as a calcium antagonist inhibitor excitatory amino acids. The magnesium sulfate on cerebrovascular permeability to dye, Evans blue, were studied during insulin-induced hypoglycemia with hypothermia in rats. Hypoglycemia was induced by an intramuscular injection insulin. After giving insulin, each animal received MgSO 4 (270 mg/kg) ip, followed 27 mg/kg dose every 20 min...
Cyclosporine A (CsA) is an immunosuppressive drug, used in organ transplantations. Oxidative stress, inflammation and renin-angiotensin system (RAS) activation play important role CsA-toxicity. Glycine (Gly) has antioxidant anti-inflammatory effects. In this study, Gly was investigated for its protective against CsA-induced toxicity. CsA (20 mg/kg/day; subcutaneously) administered to rats along with injection (250 or 1000 mg/kg; intraperitoneally) 21 days. Renal function markers [serum urea...
The authors investigated the effects of lipopolysaccharide (LPS) on blood-brain barrier (BBB) integrity and activity astrocytes during Nw-nitro-L-arginine methyl ester (L-NAME) hypertension followed by angiotensin (ANG) II in rats. They measured changes BBB permeability using Evans blue (EB) dye concomitantly levels TNF-a, IL-1b, IL-6 serum nitric oxide plasma. performed two tight junction-specific proteins, zonula occludens-1 occludin, glial fibrillary acidic protein, immunohisto-chemical...
The objective of this study was to investigate the effect hypothermia on blood-brain barrier (BBB) disruption caused by traumatic brain injury (TBI) in chronically ethanol-treated rats. BBB permeability measured using Evans blue (EB) dye. Arterial blood pressure levels animals hypothermic groups decreased significantly. EB dye extravasation into significantly increased and at 6 24 h after TBI. In rats that were subjected TBI, led a significant decrease content but not TBI when compared with alone.
<title>Abstract</title> <bold>Objective</bold> Oxidative stress, inflammation and renin-angiotensin system (RAS) activation play an important role in the nephrotoxicity which is caused by long-term use of immunosuppressive drug cyclosporine (CsA). This study investigates whether chenodeoxycholic acid (CDCA), endogenous farnesoid X receptor (FXR) agonist with antioxidant anti-inflammatory effects, modulates CsA nephrotoxicity. <bold>Methods</bold> (25 mg/kg/day; s.c.) was administered to rats...