A5011164144- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Vitamin D Research Studies
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Hormonal and reproductive studies
- Myasthenia Gravis and Thymoma
- Lung Cancer Research Studies
- Diabetes and associated disorders
- Sexual Differentiation and Disorders
- Ophthalmology and Eye Disorders
- Ovarian function and disorders
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Medical Imaging and Pathology Studies
- Ovarian cancer diagnosis and treatment
Carol Davila University of Medicine and Pharmacy
2016-2025
Institutul Național de Endocrinologie C.I. Parhon
2016-2025
Institute of Endocrinology
2012-2022
Clinical Emergency Hospital Bucharest
2018-2022
University Radiology
2022
Spitalul Clinic Dr. C. I. Parhon
2021
Endocrinology Research Center
2015-2019
Avila University
2008-2018
University of Medicine and Pharmacy of Craiova
2011
Prolactinomas are the most frequent pituitary adenomas. Prolactinoma may occur in different clinical settings and always require an individually tailored approach. This is reason why a panel of Italian neuroendocrine experts was charged with task to provide indications for diagnostic therapeutic approaches that can be easily applied contexts. The document provides 15 recommendations diagnosis 54 treatment, issued according GRADE system. level agreement among members formally evaluated by...
Evidence regarding the relation between SARS-CoV-2 mortality and underlying medical condition is scarce. We conducted an observational, retrospective study based on Romanian official data about location, age, gender comorbidities for COVID-19 fatalities. Our findings indicate that males, hypertension, diabetes, obesity chronic kidney disease were most frequent in fatalities, burden of was low, prognosis 1-year survival probability high sample. shows age-dependent pairs could be a negative...
Introduction The mortality ratio in patients with acromegaly has improved over the last few decades. We aimed to determine rate and correlated factors before after introduction of national protocols for treatment. In addition, we determined whether there are sex-related differences acromegaly. Methods This observational retrospective study included 399 consecutive between January 2001–December 2022. Paraclinical data random growth hormone (GH) insulin-like factor-I (IGF1) levels, maximal...
Abstract In several studies, hyperprolactinemia has been associated with increased breast cancer risk. Evidence shows that prolactin (PRL) is linked to mammary tumorigenesis, especially in postmenopausal patients, but the data remain controversial. We present a case of 67 year-old patient resistant PRL-secreting PitNET who subsequently developed cancer. The was known have persistent high PRL levels despite multimodal treatment (surgery, radiotherapy, and doses cabergoline). tumor specimens...
Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting choices European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, geo-economic factors relate to choices. Methods. 17,247 from 28 countries were invited participate in an online questionnaire survey. The included respondent demographic data for hypothyroid patients with symptoms. Geo-economic each country the analyses....
Introduction: Acromegaly is a rare, serious endocrine disorder characterized by excess growth hormone (GH) secretion pituitary adenoma and overproduction of insulin-like factor I (IGF-I). Transsphenoidal surgery the treatment choice, although many patients require additional interventions. First-generation somatostatin analogues (SSAs) are current standard medical therapy; however, not all achieve control GH IGF-I. Outcomes from Phase IIIb open-label study with uncontrolled acromegaly on...
Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development diabetes. To define determinants insulin resistance (IR) we investigated 73 genes involved BCAA metabolism or regulation by fine-scale haplotype mapping two European populations with metabolic syndrome. French Romanians (n = 465) were genotyped SNPs (Affymetrix) enriched imputation (BEAGLE 4.1) at...
This study aimed to investigate an unusual case of immature ovarian teratoma with onset mature glial cells implanted on the contralateral ovary, a challenge in diagnosis second tumor. We report 31- yr-old woman, who developed at age 16 right ovary that was surgically removed. Six years later implants were present left and six months level peritoneum relapsed after other months. The patient suffered three surgical resections initial one. Paraffin sections immunohistochemical examinations...
The number of international acromegaly related registries is increasing; however, heterogeneity symptoms and signs across countries not well described. We compared clinical disease manifestations at diagnosis between two large University referral centers from continents.Retrospective, comparative epidemiological study patients centers: (i) C. I. Parhon National Institute Endocrinology, 'Carol Davila' Medicine Pharmacy Bucharest, Romania (Parhon), (ii) Pituitary Center, Oregon Health &...
Introduction Thyroid specialists influence how hypothyroid patients are treated, including managed in primary care. Given that physician characteristics patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors. Methods from 28 countries were invited respond a questionnaire, Treatment of Hypothyroidism Europe by Specialists: an International Survey (THESIS). Geographic regions defined according the United Nations Statistics Division. The...
Osteoporosis (OP) is a disease predisposing postmenopausal women to fractures, and often accompanied by insulin resistance (IR) metabolic syndrome (MetS). Previous studies provided contradictory results concerning prevalence of MetS in OP. To better understand the pathogenesis IR, we reviewed cellular molecular aspects systematically providing homeostasis model assessment (HOMA) index. Bone an active endocrine organ maintaining its integrity orchestrated balance between bone formation...
Abstract Objectives The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb) is not supported by the available evidence. aim study was document LT4 European specialists such patients. Design data presented derive from Treatment Hypothyroidism Europe Specialists, an International Survey (THESIS), a questionnaire conducted between 2019 and 2021 management hypothyroidism specialists. Here, we report aggregate...
Vitamin D deficiency and vitamin receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, adhesion malignant tumors. This study investigated whether levels genetic variations VDR risk factors for thyroid cancer.Patients who underwent surgery differentiated carcinoma (n=113) those with benign pathology (n=150) were genotyped (ApaI, TaqI, FokI, BsmI) their 25(OH)D simultaneously measured. Demographic data histopathologic...