A5020282164- Ophthalmology and Eye Disorders
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Advanced Glycation End Products research
- Glaucoma and retinal disorders
- Head and Neck Cancer Studies
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Fibroblast Growth Factor Research
- Head and Neck Anomalies
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Parathyroid Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Diet and metabolism studies
- Kruppel-like factors research
University of Debrecen
2014-2025
Centre Hospitalier Universitaire de Grenoble
2012-2016
Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting choices European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, geo-economic factors relate to choices. Methods. 17,247 from 28 countries were invited participate in an online questionnaire survey. The included respondent demographic data for hypothyroid patients with symptoms. Geo-economic each country the analyses....
Background/Objectives: Type 2 diabetes mellitus (T2DM) and its macro- microvascular complications are major health concerns with multiple factors, like advanced end glycation products (AGEs), in the background. AGEs induce long-lasting functional modification of proteins collagen vascular wall nerve tissue. We investigated effect alpha-lipoic acid (ALA) treatment on AGEs, soluble AGE receptor (sRAGE), AGE/sRAGE ratio, parameters endothelial dysfunction their correlations. Methods: In our...
Összefoglaló. Bevezetés: A pajzsmirigy-alulműködés gyakori betegség. Kezelésében a levotiroxin (LT4)-pótlás szokásos eljárás, mely tabletta vagy gélkapszula formájában áll rendelkezésre Magyarországon. nemzetközi trendeknek megfelelően az esetek korai felismerése miatt már kevésbé kifejezett hormonális eltérések idején elindul kezelés. Az endokrinológusok hypothyreosiskezelési szokásaival kapcsolatban Magyarországon és Európában felmérés eddig nem történt. Célkitűzés: THESIS (Treatment of...
Introduction Thyroid specialists influence how hypothyroid patients are treated, including managed in primary care. Given that physician characteristics patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors. Methods from 28 countries were invited respond a questionnaire, Treatment of Hypothyroidism Europe by Specialists: an International Survey (THESIS). Geographic regions defined according the United Nations Statistics Division. The...
The aim of this investigations was to study the effectiveness anti-CD20 antibody therapy in Graves' orbitopathy (GO) resistant glucocorticoids. Five patients were entered study. protocol required no improvement orbital status after a recent course Activity GO confirmed by three independent techniques: clinical activity score (CAS), 99mTc-labeled diethylene triamine pentaacetic acid (99mTc DTPA) single photon emission computed tomography and magnetic resonance imaging. Rituximab (RTX) given...
Abstract Objectives The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb) is not supported by the available evidence. aim study was document LT4 European specialists such patients. Design data presented derive from Treatment Hypothyroidism Europe Specialists, an International Survey (THESIS), a questionnaire conducted between 2019 and 2021 management hypothyroidism specialists. Here, we report aggregate...
Background Advanced glycation end products (AGEs) are heterogenous group of irreversible chemical moieties originated from non-enzymatic and oxidation proteins, nucleic acids, lipids. The engagement AGEs with their chief cellular receptor (RAGE) activates a myriad signaling pathways contributing to the progression chronic diseases like autoimmune thyroiditis, type 2 diabetes mellitus its complications. Soluble RAGE (sRAGE) prevents AGE-RAGE interaction in competitive manner. Objective We...
During the course of Graves’ orbitopathy (GO), orbital fibroblasts are exposed to factors that lead proliferation and extracellular matrix (ECM) overproduction. Increased levels tissue plasminogen activator inhibitor type 1 (PAI-1 (SERPINE1)) might promote accumulation ECM components. PAI-1 expression is regulated by cell density various cytokines growth including transforming factorβ(TGF-β). We examined effects increasing densities TGF-β on obtained from GO patients controls. Responses were...
Introduction Adult growth hormone deficiency (AGHD) is associated with a high prevalence of metabolic syndrome (MS), which contributes to the unfavorable cardiovascular risk profile in these patients. Insulin like factor-1 (IGF-1) widely used biomarker, however it does not always reflect cardiometabolic and has poor relationship clinical efficacy endpoints. Consequently, there an unmet need for biomarkers monitor responses GH-replacement. Afamin hormone-like glycoprotein, expressed liver....
Background Insulinomas are rare insulin-secreting neuroendocrine neoplasms of the pancreas. First-line treatment is surgical removal tumor, however, localization with standard imaging techniques often challenging. With help selective intraarterial calcium stimulation insulinoma’s can be narrowed down to one third pancreas which selected artery supplies. Objective We aimed prove usefulness test in case 9 patients treated between 2006 and 2021 diagnosed endogenous hyperinsulinemic hypoglycemia...
Purpose: Hyaluronan (HA) overproduction by orbital fibroblasts (OFs) is a major factor in the pathogenesis of Graves' orbitopathy (GO). 4-methylumbelliferone (4-MU) an inhibitor HA synthesis different cell types vitro and has beneficial effects animal models autoimmune diseases. Methods: production mRNA expression synthases (HAS1, HAS2, HAS3) hyaluronidases (HYAL1 HYAL2) were measured presence absence 4-MU unstimulated transforming growth factor–β–stimulated from GO (n = 4), non-GO dermal...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Purpose The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as reflected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European specialists. Methods Specialists from 28 countries were invited a survey via professional organisations. relevant question was whether “ Thyroid may be indicated biochemically euthyroid patients resistant lifestyle interventions” . Results Of 17,232...
Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, adipose tissues. We aimed to investigate serum FGF21 level its relation thyroid hormones metabolic parameters among patients with Hashimoto's thyroiditis (HT).