A5049861962- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Diabetes and associated disorders
- Thyroid and Parathyroid Surgery
- S100 Proteins and Annexins
- Pituitary Gland Disorders and Treatments
- Connective Tissue Growth Factor Research
- Biomarkers in Disease Mechanisms
- Hypothalamic control of reproductive hormones
- Erythrocyte Function and Pathophysiology
- Clusterin in disease pathology
- Global Cancer Incidence and Screening
- Bone health and treatments
- Connective tissue disorders research
- Mitochondrial Function and Pathology
- Iron Metabolism and Disorders
- Birth, Development, and Health
- NF-κB Signaling Pathways
- Effects of Radiation Exposure
- Disaster Response and Management
- Lymphatic System and Diseases
- Sympathectomy and Hyperhidrosis Treatments
Skåne University Hospital
2015-2024
Lund University
2015-2024
Diabetes Australia
2010
Genomics (United Kingdom)
2010
Abstract Context/objective The aim of this study was to examine the effect statins and other lipid-lowering agents on development Graves orbitopathy (GO) in patients with newly diagnosed disease (GD). Methods Our sample included full adult population individuals living Sweden GD between 2005 2018 (n = 34 894). We compared GO incidence statin users 5574) nonusers 409) by applying Cox regression a time-varying exposure variable. adjusted for age, sex, treatment hyperthyroidism multivariate...
Patients with low thyroid peroxidase antibodies (anti-TPO) and increased TSH-receptor (TRAb) at diagnosis of Graves' disease (GD) have been suggested to an risk develop ophthalmopathy (GO). The aim was evaluate if GO development can be predicted.This is observational study registration possible GD factors.399 patients were registered 2003-2008 in Malmö, Sweden out these 310 retrospectively followed up 6 years. main outcome measures anti-TPO titer, TRAb smoking habits, radioiodine treatment...
The aim was to compare the vitamin D levels in patients with Graves disease (GD) general population and correlate laboratory clinical parameters GD. Moreover, we examined genetic variation genes involved metabolism their association GD.The of were compared 292 newly diagnosed GD 2,305 controls. Single nucleotide polymorphisms (SNPs) receptor (VDR), binding protein (DBP), 1-α-hydroxylase (CYP27B1) for and/or ophthalmopathy (GO) 708 1,178 controls.Patients had significantly lower controls...
Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting choices European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, geo-economic factors relate to choices. Methods. 17,247 from 28 countries were invited participate in an online questionnaire survey. The included respondent demographic data for hypothyroid patients with symptoms. Geo-economic each country the analyses....
Introduction Graves´ disease (GD) is the predominant cause of hyperthyroidism. Treatment options include antithyroid drugs (ATD), surgery, and radioactive iodine ablation (RI). Although thyroid peroxidase antibodies (anti-TPO) are prevalent in patients with GD, their role driving relapse or hypothyroidism after treatment GD remains unclear. This study aimed to determine if anti-TPO at diagnosis more likely ATD RI treatment, increased risk developing post-ATD treatment. Methods was an...
Cigarette smoking is a risk factor for the development of Graves' ophthalmopathy (GO). In previous study gene expression in intraorbital fat, adipocyte-related immediate early genes (IEGs) were overexpressed patients with GO compared to controls. We investigated whether IEGs are upregulated by smoking, and examined other pathways that may be affected smoking.Gene fat was studied smokers (n=8) nonsmokers severe active GO, as well subcutaneous thyroid-healthy (n=5) using microarray real-time...
A potentially altered protein expression profile in orbital tissue from patients with thyroid-associated orbitopathy (TAO) is suspected. To detect for the first time changes proteomic patterns of connective TAO and compare these control using mass spectrometry. Proteomics cross-sectional, comparative study. Two academic endocrine institutions. total 64 peripheral adipose samples were collected 39 25 subjects. Samples analyzed identified matrix-assisted laser desorption/ionization...
Background: The prescription of liothyronine (LT3) to treat hypothyroidism is increasing worldwide; however, the long-term safety LT3 use has yet be determined. Previous studies have suggested a possible association between and breast cancer. aim this study was examine effects on cancer incidence mortality. Methods: Our sample included full adult population individuals living in Sweden with at least three purchases thyroid hormone therapy July 2005 December 2017. Individual-level data drug...
Smoking is a strong risk factor for the development of Graves' ophthalmopathy (GO). Immediate early genes (IEGs) are overexpressed in patients with active GO compared to healthy controls. The aim this study was effects tobacco smoking and simvastatin on preadipocytes orbital fibroblasts (OFs) adipogenic process.Cigarette smoke extract (CSE) generated by validated pump system. Mouse 3T3-L1 or OFs were exposed 10% CSE without simvastatin. Gene expression studied unexposed cells treated...
Background: Graves' ophthalmopathy (GO) and lymphedema share some pathogenetic mechanisms, such as edema, inflammation, adipogenesis. The aim of this study was to examine similarities differences between chronic GO lymphedema. Methods: Intraorbital adipose tissue collected from patients with active (n = 10) or thyroid-healthy controls 10). Arm subcutaneous obtained arm 10), where the unaffected served a control. Gene expression studied using microarray real-time polymerase chain reaction....
Background The standard treatment of hypothyroidism is levothyroxine (LT-4). However, there are several controversies regarding hypothyroid patients. Aim To investigate the Swedish endocrinologists’ use thyroid hormones in and euthyroid individuals. Methods Physician members Endocrine Society (SEF) were invited by e-mail to participate an online survey investigating this topic. Results Out eligible 411 members, 116 (28.2%) responded. majority (98.9%) stated that L-T4 choice. around 50% also...
Introduction Thyroid specialists influence how hypothyroid patients are treated, including managed in primary care. Given that physician characteristics patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors. Methods from 28 countries were invited respond a questionnaire, Treatment of Hypothyroidism Europe by Specialists: an International Survey (THESIS). Geographic regions defined according the United Nations Statistics Division. The...
Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In expression study intraorbital tissue, adipocyte-related immediate early genes (IEGs) immunomodulatory were found be overexpressed in patients with ophthalmopathy (GO). We hypothesized that variations these could associated GD and/or GO.A total 98 single nucleotide polymorphisms (SNPs) 12 genotyped 594 (n=267) or without (n=327) GO 1147 sex- ethnicity-matched controls from Malmö,...
Abstract Objectives The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb) is not supported by the available evidence. aim study was document LT4 European specialists such patients. Design data presented derive from Treatment Hypothyroidism Europe Specialists, an International Survey (THESIS), a questionnaire conducted between 2019 and 2021 management hypothyroidism specialists. Here, we report aggregate...
In Graves' disease (GD), immunocompetent cells infiltrate thyroid tissue with release of TSH-receptor antibodies (TRAb), and radioiodine treatment is known to elicit an immune response increase in TRAb.The aim was study if all patients treated respond a TRAb, anti-thyroperoxidase (anti-TPO), anti-thyroglobulin (anti-TG).This prospective observational study. GD (n = 131) were admitted for radioiodine. Thyroid measured before 3 months after iodine-131 treatment.After months, fold change > 1.1...
Background and aims Genetic variants involved in vitamin D metabolism have been associated with diabetes related syndromes/diseases. We wanted to investigate possible associations of polymorphisms genes indices insulin resistance secretion, also development after gestational mellitus (GDM). Materials methods studied 376 women previous GDM. Eight single nucleotide (SNPs) the for receptor (VDR) [rs731236, rs7975232, rs10735810, rs1544410], binding protein (DBP) [rs7041 rs4588], cytochrome P450...
Graves' disease (GD) and ophthalmopathy (GO) are complex autoimmune diseases. This study delved into the impact of cigarette smoke extract (CSE), simvastatin, and/or diclofenac on peripheral blood mononuclear cells (PBMCs). Specifically, we explored alterations in IL-1B, IL-6, PTGS2 expression, B- T-lymphocyte proliferation, Immunoglobulin G (IgG) production. We also assessed IGF1's influence proliferation. PBMCs from patients were exposed to CSE with/without simvastatin diclofenac. Gene...
Background: Orbital morphological changes are often present in patients with Graves' disease (GD) already at diagnosis, and cyclooxygenase type 2 (COX-2) is overexpressed active ophthalmopathy (GO). Objective: To investigate if adjuvant treatment of GD the COX inhibitor peroxisome proliferator-activated receptor-γ (PPAR-γ) antagonist diclofenac decreases development laboratory parameters affected. Methods: This a multicenter trial where 61 subjects were randomized to methimazole (block...
The development of Graves' disease (GD) after subacute thyroiditis (SAT) is very rare and only a limited number cases have been reported.Here, we report patient with SAT followed by hypothyroidism later GD, ophthalmopathy, occurring 11 years SAT.This case illustrates the appearance thyroid-stimulating hormone (TSH) receptor antibodies in female 1 year SAT, requiring thyroxine, occurrence GD severe SAT. may be coincidental but induced TSH-receptor antibodies, bioactivity changing from...
Population-based studies have indicated an increase in bone turnover hyperthyroidism with a subsequent decrease mineral density and increased risk of fractures, especially postmenopausal women. However, heterogeneity between prevents definitive conclusion. Graves' disease (GD) is autoimmune disease, it the most common cause hyperthyroidism. The aim this study was to investigate fracture patients GD.
In gender-skewed conditions such as Graves' disease (GD), the outcome naturally becomes dominated by majority. This may lead to gender-biased misunderstandings regarding treatment outcomes. especially holds true when complications, depression, are unevenly distributed. We have, therefore, studied long-term of GD from a gender perspective.A cohort 1186 patients with was included in follow-up 6-10 years after inclusion. Choice treatment, feeling recovery, comorbidity, and quality life were...
Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of active form thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and important for maintaining intracellular T3 levels. Single nucleotide polymorphisms (SNPs) in DIO2 were associated with several diseases. The association SNPs Graves' disease (GD) was suggested Russian studies.The aim study to examine whether are GD or ophthalmopathy (GO).Seven gene - rs225014 (Thr92Ala), rs12885300, rs2267872, rs225011, rs224995,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Purpose The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as reflected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European specialists. Methods Specialists from 28 countries were invited a survey via professional organisations. relevant question was whether “ Thyroid may be indicated biochemically euthyroid patients resistant lifestyle interventions” . Results Of 17,232...