A5016129186- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Mitochondrial Function and Pathology
- Diabetes and associated disorders
- Neonatal Health and Biochemistry
- Pregnancy and preeclampsia studies
- Neuroendocrine Tumor Research Advances
- Bone health and osteoporosis research
- Cerebral Venous Sinus Thrombosis
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Hypothalamic control of reproductive hormones
- Effects of Radiation Exposure
- Adipose Tissue and Metabolism
- Erythrocyte Function and Pathophysiology
- Metabolism and Genetic Disorders
- Ion channel regulation and function
- NF-κB Signaling Pathways
- Birth, Development, and Health
- Eosinophilic Disorders and Syndromes
- Microscopic Colitis
Skåne University Hospital
2011-2024
Lund University
2011-2023
Diabetes Australia
1986-2013
Malmö University
2008-2010
Genomics (United Kingdom)
1986-2007
Introduction The incidence of hyperthyroidism has been reported in various countries to be 23–93/100 000 inhabitants per year. This extended study evaluated the for ∼40% Swedish population 9 million inhabitants. Sweden is considered iodine sufficient country. Methods All patients including children, who were newly diagnosed with overt years 2003–2005, prospectively registered a multicenter study. inclusion criteria are as follows: clinical symptoms and/or signs plasma TSH concentration below...
Thyroid hormones are important for normal fetal development. Maternal hypothyroidism during early pregnancy is associated with impaired neuropsychological development of children and other adverse outcomes. The primary aim this prospective study was to determine whether thyroxine-treated pregnant women adequately thyroxine substituted in pregnancy. A secondary if loss differed between females thyrotropin (TSH) values within outside the reference range at their first TSH test, scheduled 1-2...
Patients with low thyroid peroxidase antibodies (anti-TPO) and increased TSH-receptor (TRAb) at diagnosis of Graves' disease (GD) have been suggested to an risk develop ophthalmopathy (GO). The aim was evaluate if GO development can be predicted.This is observational study registration possible GD factors.399 patients were registered 2003-2008 in Malmö, Sweden out these 310 retrospectively followed up 6 years. main outcome measures anti-TPO titer, TRAb smoking habits, radioiodine treatment...
Background. Hypothyroidism is common, however, aspects of its treatment remain controversial. Our survey aimed at documenting choices European thyroid specialists and exploring how patients' persistent symptoms, clinician demographics, geo-economic factors relate to choices. Methods. 17,247 from 28 countries were invited participate in an online questionnaire survey. The included respondent demographic data for hypothyroid patients with symptoms. Geo-economic each country the analyses....
To investigate the incidence of hyperthyroidism in Stockholm County, those patients who were diagnosed with for first time during years 2003-2005.All new cases > or = 18 age prospectively registered to calculate total hyperthyroidism, as well subgroups: Graves' disease (GD), toxic multinodular goitre and solitary adenoma (STA). Eight specialized units/hospitals County participated registration. The participating physicians all specialists medical endocrinology, oncology, nuclear medicine...
Cigarette smoking is a risk factor for the development of Graves' ophthalmopathy (GO). In previous study gene expression in intraorbital fat, adipocyte-related immediate early genes (IEGs) were overexpressed patients with GO compared to controls. We investigated whether IEGs are upregulated by smoking, and examined other pathways that may be affected smoking.Gene fat was studied smokers (n=8) nonsmokers severe active GO, as well subcutaneous thyroid-healthy (n=5) using microarray real-time...
The objective of this study was to investigate quality life (QoL) in patients with Graves' disease treated radioiodine or antithyroid drugs.The design the consists an open, prospective, randomized multicenter trial between and medical treatment. A total 308 were included group: 145 group 163 group. QoL measured a 36-item Short Form Health Status Survey questionnaire (SF-36) at six time points during 48-month period.Patient who developed got worse thyroid-associated ophthalmopathy (TAO) any...
Background The standard treatment of hypothyroidism is levothyroxine (LT-4). However, there are several controversies regarding hypothyroid patients. Aim To investigate the Swedish endocrinologists’ use thyroid hormones in and euthyroid individuals. Methods Physician members Endocrine Society (SEF) were invited by e-mail to participate an online survey investigating this topic. Results Out eligible 411 members, 116 (28.2%) responded. majority (98.9%) stated that L-T4 choice. around 50% also...
Introduction Thyroid specialists influence how hypothyroid patients are treated, including managed in primary care. Given that physician characteristics patient care, this study aimed to explore thyroid specialist profiles and associations with geo-economic factors. Methods from 28 countries were invited respond a questionnaire, Treatment of Hypothyroidism Europe by Specialists: an International Survey (THESIS). Geographic regions defined according the United Nations Statistics Division. The...
Environmental and genetic factors influence thyrotoxicosis, but how population migration affects the disease panorama is not known. In an urban area in southern Sweden, during years 1990 until 2003, increased from 232 000 to 267 000. parallel, proportion of inhabitants born outside Sweden increased. The aim was investigate whether incidence Graves' thyrotoxicosis (GD), toxic multinodular goiter (TMNG), solitary adenoma (STA) has changed Malmö since study geographic origin.An open label...
In Graves' disease (GD), immunocompetent cells infiltrate thyroid tissue with release of TSH-receptor antibodies (TRAb), and radioiodine treatment is known to elicit an immune response increase in TRAb.The aim was study if all patients treated respond a TRAb, anti-thyroperoxidase (anti-TPO), anti-thyroglobulin (anti-TG).This prospective observational study. GD (n = 131) were admitted for radioiodine. Thyroid measured before 3 months after iodine-131 treatment.After months, fold change > 1.1...
Background and aims. Microscopic colitis (MC), predominantly affecting women, is associated with thyroid disorders, although purely defined of which type, or compared controls. Its association subclinical related increased risk cardiovascular diseases, has never been examined. The aim was to examine the prevalence autoantibodies clinical dysfunction in female patients MC Methods. Women younger than 73 years old biopsy-verified from Department Gastroenterology Skåne, during 2002–2010, were...
Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk autoimmunity offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased type 1 diabetes, whereas thyroid peroxidase (TPOAb) positivity at birth is associated increased incidence disease later life. The aim this study was identify immunological changes children born mothers may be related autoantibodies.Open label prospective...
Population-based studies have indicated an increase in bone turnover hyperthyroidism with a subsequent decrease mineral density and increased risk of fractures, especially postmenopausal women. However, heterogeneity between prevents definitive conclusion. Graves' disease (GD) is autoimmune disease, it the most common cause hyperthyroidism. The aim this study was to investigate fracture patients GD.
In gender-skewed conditions such as Graves' disease (GD), the outcome naturally becomes dominated by majority. This may lead to gender-biased misunderstandings regarding treatment outcomes. especially holds true when complications, depression, are unevenly distributed. We have, therefore, studied long-term of GD from a gender perspective.A cohort 1186 patients with was included in follow-up 6-10 years after inclusion. Choice treatment, feeling recovery, comorbidity, and quality life were...
Background: Thyroid hormones induce insulin resistance. Pioglitazone is a peroxisome proliferator activated receptor gamma (PPARγ) agonist, used as treatment of type 2 diabetes (T2D) to increase sensitivity. PPARs and thyroid hormone receptors (TRs) intracellular effects through similar molecular mechanisms, the former may inhibit activation latter. has been shown eye protrusion, symptom linked both disturbed levels orbital edema secondary increased IGF-I. Aims: We investigated whether...
Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of active form thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and important for maintaining intracellular T3 levels. Single nucleotide polymorphisms (SNPs) in DIO2 were associated with several diseases. The association SNPs Graves' disease (GD) was suggested Russian studies.The aim study to examine whether are GD or ophthalmopathy (GO).Seven gene - rs225014 (Thr92Ala), rs12885300, rs2267872, rs225011, rs224995,...
Abstract Purpose The use of thyroid hormones (TH) to treat obesity is unsupported by evidence as reflected in international guidelines. We explored views about this practice, and associations with respondent characteristics among European specialists. Methods Specialists from 28 countries were invited a survey via professional organisations. relevant question was whether “ Thyroid may be indicated biochemically euthyroid patients resistant lifestyle interventions” . Results Of 17,232...
Treatment of Graves´ disease (GD) with radioiodine increases the risk developing ophthalmopathy (GO), and link between thyroid orbital tissue may be presence TSH-receptors. Radioiodine titers TRAb aim was to investigate relationship GO after treatment define impact genes.GD patients without or previous were prospectively included at for hyperthyroidism. A follow-up performed 1 year later registration development. The study a University Hospital Clinic; referral center all treated in south...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)