A5076255873- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Cannabis and Cannabinoid Research
- Protein Degradation and Inhibitors
- Contact Dermatitis and Allergies
- Biochemical effects in animals
- Chromatin Remodeling and Cancer
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Myasthenia Gravis and Thymoma
- Neurotransmitter Receptor Influence on Behavior
- Pericarditis and Cardiac Tamponade
- Glioma Diagnosis and Treatment
Victor Babeș University of Medicine and Pharmacy Timișoara
2023-2025
Institutul Național de Endocrinologie C.I. Parhon
2021
Institute of Endocrinology
2021
In several studies, hyperprolactinemia has been associated with increased breast cancer risk. Evidence shows that prolactin (PRL) is linked to mammary tumorigenesis, especially in postmenopausal patients, but the data remain controversial. We present a case of 67 year-old patient resistant PRL-secreting PitNET who subsequently developed cancer. The was known have persistent high PRL levels despite multimodal treatment (surgery, radiotherapy, and doses cabergoline). tumor specimens obtained...
The classification of pituitary neuroendocrine tumors (PitNETs), also known as adenomas, has progressed significantly since 2004. PitNET lineage now serves the foundation classification. We investigated prognostic value clinicopathological markers in a cohort patients diagnosed with acromegaly and prolactinomas who underwent transsphenoidal tumor resection. A total 50 (45 confirmed 5 prolactinomas) evidence at 'C. I. Parhon National Institute Endocrinology (Pituitary Neuroendocrine Pathology...
Pituitary neuroendocrine tumors (PitNETs) are divided into multiple histological subtypes, which determine their clinical and biological variable behavior. Despite benign evolution, in some cases, prolactin (PRL) growth hormone (GH)-secreting PitNETs may have aggressive In this study, we investigated the potential predictive role of ER∝, alongside clinicopathological classification (tumor diameter, tumor type, grade). A retrospective study was conducted with 32 consecutive cases PRL- mixed...
Background/Aim: The histopathological variability of each type pituitary adenoma (PA) that causes growth hormone (GH) excess influences the phenotype, radiological characteristics and therapy response acromegaly patients. We correlated immunohistochemical (IHC) features GH-secreting PAs with their clinical, laboratory imaging data. Patients Methods: included 32 patients documented acromegaly; tumour specimens were histologically IHC examined: anterior hormones, pituitary-specific...
Plurihormonal pituitary neuroendocrine tumors (PitNETs) are rare forms of that express more than one hormone. The most common association is between growth hormone (GH) and prolactin (PRL), but other unusual combinations have been reported, such as GH ACTH. Usually, the clinical dominance in these cases related to hypersecretion. In cases, immunohistochemistry (IHC) transcription factors (TFs) very useful for an accurate diagnosis. We included 42 patients diagnosed with (PitNETs): 37 a...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)