A5080727335- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Climate Change and Health Impacts
- Inhalation and Respiratory Drug Delivery
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- COVID-19 impact on air quality
- Extracellular vesicles in disease
Koç University
2022-2024
Air pollution plays an important role in the mortality and morbidity of chronic airway diseases, such as asthma obstructive pulmonary disease (COPD). Particulate matter (PM) is a significant fraction air pollutants, studies have demonstrated that it can cause inflammation injury. The epithelium forms first barrier defense against inhaled toxicants, PM. Airway epithelial cells clear airways from irritants orchestrate inflammatory response to these by secreting various lipid mediators, growth...
The multisystemic effects of COVID-19 may continue for a longer time period following the acute phase, depending on severity disease. However, long-term systemic transcriptomic changes associated with disease and impact are not fully understood. We aimed to investigate its alterations in peripheral blood mononuclear cells (PBMCs) 1 year PBMCs were isolated from healthy control donors who did have (C; n = 13), patients without pneumonia (NP; 11), severe (SP; 10) after 1-year follow-up....
Summary Chronic airway diseases, such as Obstructive Pulmonary Disease (COPD) and asthma pose a significant global health burden. The pathophysiology involves chronic inflammation, with oxidative stress playing crucial role in disease severity. Current treatments, especially for COPD, have limitations, necessitating exploration of alternative therapeutic approaches. In this study, we investigated the potential effects butyrate, short-chain fatty acid, on epithelial cells. Human bronchial...
Abstract Long-COVID-19 manifests as a multisystemic condition with varied symptoms lingering beyond three weeks of acute SARS-CoV-2 infection, though its underlying mechanisms remain elusive. Aiming to decipher the long-term molecular impacts COVID-19, we conducted transcriptomic analysis on PBMCs from 1-year post-covid patients, including individuals without pneumonia (NP, n=10), those severe (SP, n=11), and healthy controls (C, n=13). Our extensive RNA sequencing revealed 4843...