A5023619301- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- CRISPR and Genetic Engineering
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Bone fractures and treatments
- Animal Genetics and Reproduction
- Ovarian cancer diagnosis and treatment
- Pluripotent Stem Cells Research
- Wound Healing and Treatments
- Neuroscience and Neuropharmacology Research
- Orthopaedic implants and arthroplasty
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Pelvic and Acetabular Injuries
- Cerebrovascular and Carotid Artery Diseases
- Infections and bacterial resistance
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
Koç University
2015-2024
Zübeyde Hanim Maternity Hospital
2013-2014
Creighton University
2010
Ankara University
2006-2009
Abstract Cells in the umbilical cord stroma have gained attention recent years; however, differentiation to certain lineages humans has been demonstrated few studies. Unlike bone marrow MSCs, human cells (HUCSCs) are far from being well characterized. This study attempts describe proliferation, structural, and properties of these account for their exceptional nature many aspects. Cellular dynamics, cellular structure, degree transformations during expansion into mesenchymal neuronal were...
Is there any in vitro evidence for or against ovarian protection by co-administration of a GnRH agonist with chemotherapy human? The leuprolide acetate cytotoxic agents does not preserve reserve vitro. Randomized controlled trials the gonadotrophin-releasing hormone (GnRH) agonists adjuvant to function have shown contradictory results. This fact, together lack proven molecular mechanism action (GnRHa) places this approach as fertility preservation strategy under scrutiny. We therefore aimed...
Harakiri (HRK) is a BH3-only protein of the Bcl-2 family and regulates apoptosis by interfering with anti-apoptotic Bcl-xL proteins. While its function mainly characterized in nervous system, role tumors ill-defined few studies demonstrating HRK silencing tumors. In this study, we investigated most aggressive primary brain tumor, glioblastoma multiforme (GBM). We showed that differentially expressed among established GBM cell lines overexpression can induce cells at different levels. This...
Abstract It has been previously demonstrated that human umbilical cord stroma-derived stem cells (HUCSCs) are competent to differentiate into adipocytes. However, controversies have arisen as whether HUCSCs can become mature adipocytes or not, and what extent these be induced in adipogenic pathway. Here, we extensively analyzed their potency with a structural functional approach by determining lipid formation dynamics concordance adipocyte-specific markers. During 35-day period, respond...
There is a controversy in literature as to whether c-Abl crucial for the induction of TAp63-mediated apoptosis and that inhibition with imatinib, which was designed inhibit oncogenic kinase BCR-ABL c-kit, protects oocytes from chemotherapy-induced mice. No human data are available on this issue. We therefore aimed explore genomic damage induced by chemotherapy drug cisplatin activates along TAp63 imatinib prevents cisplatin-induced oocyte death follicle loss ovary. Exposure DNA damage,...
Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively kill tumor cells. TRAIL resistance in cancers is associated with aberrant expression of the key components apoptotic program. However, how these are regulated at epigenetic level not understood. In this study, we investigated novel mechanisms regulating response glioblastoma multiforme (GBM) cells by a short-hairpin RNA loss-of-function screen. We interrogated 48 genes DNA and histone modification...
Soluble ACE2 (sACE2) decoys are promising agents to inhibit SARS-CoV-2, as their efficiency is unlikely be affected by escape mutations. However, success limited relatively poor potency. To address this challenge, multimeric sACE2 consisting of SunTag or MoonTag systems developed. These extremely effective in neutralizing SARS-CoV-2 pseudoviral and clinical isolates, perform better than the dimeric trimeric sACE2, exhibit greater 100-fold neutralization efficiency, compared monomeric sACE2....
Chronic hepatitis B infection is characterized by hepatic immune and inflammatory response with considerable variation in the rates of progression to cirrhosis. Genetic variants environmental cues influence predisposition development chronic liver disease; however, it remains unknown if aberrant DNA methylation associated fibrosis B. To identify epigenetic marks fibrotic processes B-induced disease, we carried out genome-wide profiling using Illumina Infinium BeadArrays comparing mild severe...
Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity L. Roem in wound healing both vivo vitro using an excisional model mice. used four groups eight mice as follows: untreated (control), empty gel, extract + gel (L. gel), Madecassol® groups. All treatments were applied topically once daily. The scar area, percentage closure epithelization time measured. promoted increased granulation tissue,...
In the embryonic heart, blood flow is distributed through a bilaterally paired artery system composed of aortic arches (AAs). The purpose this study to establish an understanding governing mechanism microstructural maturation AA matrix and its reversibility, toward desired macroscopic vessel lumen diameter thickness for healthy, abnormal, in ovo repaired abnormal mechanical loading. While matrix-remodeling mechanisms were significantly different normal versus conotruncal banding (CTB), both...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...
Background: To compare the effect of GnRH antagonist/letrozole/gonadotropin protocol with microdose agonist flare-up in poor ovarian responders for intracytoplasmic sperm injection.
This study aimed to investigate and compare cell growth manners functional differences of primary cortical neurons cultured on either poly-d-lysine (PDL) or Matrigel, delineate the role extracellular matrix providing resemblance in vivo cellular interactions nervous tissue. Primary neurons, obtained from embryonic day 15 mice pups, seeded PDL- Matrigel-coated culture ware were investigated by DIC/bright field fluorescence/confocal microscopy for their morphology, 2D 3D structure,...
Abstract Molecular mechanisms underlying luteinization (terminal differentiation of granulosa and theca cells after ovulation) luteolysis (demise corpus luteum) are poorly understood in human ovary. Here we report that activin-A, binding to its cognate receptors induces a functional luteolytic state reverses phenotype by downregulating the expression steroidogenic enzymes, LH receptor VEGF reducing estradiol (E 2 ) progesterone (P 4 production upregulating FSH cyclin D1 primary luteinized...
Abstract Granulosa cell tumor of the ovary (GCT) is a very rare tumor, accounting for only 2% all ovarian tumors. It originates from sex cords in and can be divided into adult (95%) juvenile (5%) types based on histologic findings. To date, no clear etiologic process has been identified other than missense point mutation FOXL2 gene. Our previous works showed that c-Jun N-terminal kinase (JNK) pathway plays critical role cycle progression mitosis normal immortalized granulosa cells follicle...