A5054342556- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Inflammasome and immune disorders
- Linguistics and Discourse Analysis
- Education, sociology, and vocational training
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- French Language Learning Methods
- Metabolism, Diabetes, and Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Educational Strategies and Epistemologies
- GDF15 and Related Biomarkers
- Barrier Structure and Function Studies
- Diet and metabolism studies
- Cardiovascular Effects of Exercise
- Genetic Neurodegenerative Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Drug Solubulity and Delivery Systems
- Tissue Engineering and Regenerative Medicine
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
UCLouvain
2021-2024
Université d'Artois
2017-2022
The blood-brain barrier (BBB) is a selective and functional gatekeeper for the central nervous system (CNS), essential maintaining brain homeostasis. BBB composed of specialized endothelial cells (BECs) lining capillaries. tight junctions formed by BECs regulate paracellular transport, whereas transcellular transport regulated transporters, pumps receptors. Cytokine-induced neuroinflammation, such as tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β), appear to play role in dysfunction...
Alzheimer’s disease (AD) is characterized by the abnormal accumulation of amyloid-β (Aβ) peptides in brain. The pathological process has not yet been clarified, although dysfunctional transport Aβ across blood–brain barrier (BBB) appears to be integral development. At present, no effective therapeutic treatment against AD exists, and adoption a ketogenic diet (KD) or ketone body (KB) supplements have investigated as potential new approaches. Despite experimental evidence supporting...
Abstract Background Obesity among older adults has increased tremendously. accelerates ageing and predisposes to age‐related conditions diseases, such as loss of endurance capacity, insulin resistance features the metabolic syndrome. Namely, ectopic lipids play a key role in development nonalcoholic fatty liver disease (NAFLD) myosteatosis, two severe burdens diseases. Adiponectin (ApN) is hormone, mainly secreted by adipocytes, which exerts insulin‐sensitizing fat‐burning properties several...
Sarcopenia, characterized by loss of muscle mass, quality, and function, poses significant risks in aging. We previously demonstrated that long-term treatment with AdipoRon (AR), an adiponectin receptor agonist, alleviated myosteatosis degeneration middle-aged obese mice. This study aimed to determine if a shorter AR could effectively offset sarcopenia older Two groups old mice (20-23 months) were studied, one untreated (O) orally-treated (O-AR) at 50 mg/kg/day for three months, compared...
Background Duchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, secondary process involving severe inflammation and necrosis exacerbate disease progression. Previously, we reported that NLRP3 inflammasome complex plays a crucial role in this disorder. Moreover, pyroptosis, form of programmed necrotic cell death, triggered by via gasdermin D (GSDMD). So far, pyroptosis has never been described either healthy muscle or dystrophic muscle. The aim study was...
Duchenne muscular dystrophy (DMD) is one of the most devastating myopathies, where severe inflammation exacerbates disease progression. Previously, we demonstrated that adiponectin (ApN), a hormone with powerful pleiotropic effects, can efficiently improve dystrophic phenotype. However, its practical therapeutic application limited. In this study, investigated ALY688, small peptide ApN receptor agonist, as potential novel treatment for DMD. Four-week-old mdx mice were subcutaneously treated...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...
Characterizing interaction of newly synthetized molecules with efflux pumps remains essential to improve their efficacy and safety. Caco-2 cell line cultivated on inserts is widely used for measuring apparent permeability drugs across biological barriers, estimating such as P-gp, BCRP MRPs. However, this method time consuming expensive. In addition, detection required molecule passage monolayer false results can be generated if concentrations are too high demonstrated quinidine. For reason,...
Adiponectin (ApN) is a hormone with potent effects on various tissues. We previously demonstrated its ability to counteract Duchenne muscular dystrophy (DMD), severe muscle disorder. However, therapeutic use limited. AdipoRon, an orally active ApN mimic, offers promising alternative. While cardiomyopathy the primary cause of mortality in DMD, or AdipoRon dystrophic hearts have not been investigated. Our recent findings significant protective skeletal muscle. In this study, we investigated...
Nous interrogeons, dans cette étude, les effets d’un dispositif qui immerge des élèves de quatrième au collège activités laboratoires recherche la perspective d’élaboration d’une énigme scientifique. examinons comment mise en récit peut articuler lecture (le lire) et l’expression structurée pensée dire) un processus continu favorise le raisonnement prenons appui sur questionnaires avec enseignants élèves, ainsi que énigmes produites pour identifier incidences motivation l’engagement lien...