A5022976703- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Bacterial Infections and Vaccines
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Anesthesia and Neurotoxicity Research
- Cancer Cells and Metastasis
- interferon and immune responses
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Chemical Reactions and Isotopes
- Receptor Mechanisms and Signaling
- Human Health and Disease
- Medicinal Plants and Bioactive Compounds
- Respiratory viral infections research
- Cancer, Hypoxia, and Metabolism
- Pediatric health and respiratory diseases
Krasnoyarsk State Medical University
2015-2022
Krasnoyarsk Regional Clinical Hospital
2020
Institute of Molecular Medicine
2016
Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising alternative strategy for the effective treatment of AD, has been actively discussed over two decades. However, mechanisms therapeutic photostimulation (PS) effects on subjects AD remain poorly understood. The goal this study was to determine PS beta-amyloid (Aβ)-injected mice. neurological severity score object recognition tests demonstrate...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...
Neurogenesis is a complex process which governs embryonic brain development and importants for plasticity throughout the whole life. Postnatal neurogenesis occurs in neurogenic niches that regulate processes of proliferation differentiation stem progenitor cells under action stimuli trigger mechanisms neuroplasticity. Cells glial endothelial origin are key regulators neurogenesis. It known physiological neurogeneses crucial memory formation, whereas reparative provides partial repair altered...
The article presents the current clinical and epidemiological features of enterovirus infection in children Krasnoyarsk Territory. A retrospective analysis incidence meningitis period 2014—2015 according to forms state statistical reporting №2 «Information on infectious parasitic diseases». Clinical 454 who were treated at MBUZ «City Children's Infectious Hospital №1» seasonal rise morbidity 2014 revealed a prevalence etiological structure enteroviruses Coxsackie B, B5, B3, B4. region...
In the central nervous system of mammals, there are specialized areas in which neurogenesis — neurogenic niches is observed postnatal period. It believed that astrocytes composition play a significant role regulation neurogenesis, and therefore they considered as promising “target” for possible control including use optogenetics. framework this work, we formed an vitro model niche, consisting cerebral endothelial cells, neurospheres. Astrocytes niche expressed canalorodopsin ChR2 underwent...
The paper presents evidence of the relevance pneumococcal infection (PI) in children Krasnoyarsk. most severe form PI is meningitis that characterizes by lesion not only meninges but brain substance, extreme severity, long-term nonsmooth flow with development complications threaten a patient's life. inclusion conjugate vaccine planned childhood immunization scheme will significantly reduce severity these diseases.
Цель исследования. Изучение пролиферативных и адгезионных свойств нейронов астроцитов при направленной модуляции активности HIF-1. Материалы методы. Исследование проводили на трехклеточной модели ГЭБ изолированных нейронах астроцитах in vitro. Активность HIF-1 подавляли ингибитором FM19G11 измеряли клеточный индекс импедансометрически клеточном анализаторе «xCelligence».Результаты.Установлено, что ингибирование снижает пролиферацию входящих в состав астроцитов.При этом присутствие системе...
GPR81 рецепторы лактата в регуляции функциональной активности клеток © БОЙЦОВА Е
The objective of the research was to study clinical and epidemiological features outcomes generalized forms meningococcal infection in children from Krasnoyarsk Territory during period 2012 2016. Materials methods. A retrospective analysis 57 medical records hospital patients with carried out infectious resuscitative departments Clinical Hospital No. 1 2016, including 12 protocols pathologoanatomical studies deceased 45 cards ambulatory – convalescents disease Results. epidemic situation for...
Aim. To study the effect of neuroinflammation inducers viral and bacterial origin on reception transport lactate in endothelial cells brain vitro. Materials Methods. In study, we incubated with (lipopolysaccharide, E. coli) various concentrations inducer inflammation (Poly I:C). After exposure, evaluated proliferative activity cells, change transendothelial electrical resistance, concentration extracellular lactate. We then performed an im-munocytochemistry investigation to record changes...
Meningococcal infection (MI) for many years has occupied one of the most important places in structure acute neuroinfections children. Some decline MI morbidity recent reduced alertness doctors to early detection disease that some cases becomes cause late hospitalization, development decompensated shock and ineffective resuscitation. The purpose given research is identify causes deaths from generalized forms prospects mortality reduction. paper gives expert analysis 22 medical histories...
The goal is to study the effects of pro-inflammatory agents on expression NLRP3 and structural integrity cerebral microvessel endothelial cells in vitro. Materials methods. was conducted a culture cells. were isolated from Wistar rat brains. Polyinosinic-polycytidylic acid (RolyI: C) – 20 µg / ml added In another series experiments, incubated with cerebrospinal fluid (CSF) obtained patients enteroviral meningitis (100 µl) used as comparison group. CSF standardized for protein concentration...
Introduction. In the study of Alzheimer’s disease (AD), cause-and-effect relationship between neurodegenerative changes and accompanying amyloid angiopathy is becoming increasingly important. The accumulated clinical data indicates that an important contribution to pathogenesis AD made by neurovascular unit dysfunction, including disruption in permeability blood-brain barrier (BBB), microcirculation, metabolic coupling cells. Aim . To molecular mechanisms disturbed brain microcirculation...