A5088861361- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Alzheimer's disease research and treatments
- Barrier Structure and Function Studies
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Inflammasome and immune disorders
- Anesthesia and Neurotoxicity Research
- Medicinal Plants and Bioactive Compounds
- Circadian rhythm and melatonin
- Aluminum toxicity and tolerance in plants and animals
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Connexins and lens biology
- S100 Proteins and Annexins
- Calcium signaling and nucleotide metabolism
- Hereditary Neurological Disorders
- Sirtuins and Resveratrol in Medicine
- Mechanisms of cancer metastasis
Krasnoyarsk State Medical University
2013-2024
Siberian Federal University
2021-2024
Gunma University
2010-2017
Institute of Molecular Medicine
2016
Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform protein kinase C (PKCγ) and modest level PKCα. The PKCγ is involved in pruning climbing fiber (CF) synapses from developing PCs, PKCα plays critical role long-term depression (LTD) at parallel (PF)-PC synapses. Moreover, PKC signaling PCs negatively modulates nonselective transient receptor potential cation channel type 3 (TRPC3), opening which elicits slow EPSCs PF-PC Autosomal dominant spinocerebellar ataxia 14 (SCA14)...
Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by gene defect, leading to movement disorder such as cerebellar ataxia. It remains largely unknown which functional defect contributes the ataxic phenotype in SCA1. In this study, we report dysfunction of metabotropic glutamate receptor (mGluR) signalling, leads smaller slow synaptic responses, reduced dendritic Ca2+ signals and impaired plasticity at synapses, early stage SCA1 model mice. We also show...
Bergmann glia (BG) are highly specialized radial astrocytes of the cerebellar cortex, which play a key role in uptake synaptic glutamate via excitatory amino acid transporter EAAT1. Multiple lines evidence suggest that neurodegenerative diseases reactive BG has negative impact on neuronal function and survival through compromised EAAT activity. A family such those caused by expansion CAG repeats genes ataxin family, resulting spinocerebellar ataxias (SCA). We investigated contribution to...
Amyloid assemblies are associated with a wide range of human disorders, including Alzheimer's and Parkinson's diseases. Here, we identify protein kinase C (PKC) γ, serine/threonine mutated in the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14), as novel amyloidogenic no previously characterized amyloid-prone domains. We found that overexpression PKCγ cultured cells, well vitro incubation without heat or chemical denaturants, causes amyloid-like fibril formation this protein....
Alzheimer's disease (AD) is a devastating neurodegenerative disorder. In recent years, attention of researchers has increasingly been focused on studying the role brain insulin resistance (BIR) in AD pathogenesis. Neuroinflammation makes significant contribution to BIR due activation NLRP3 inflammasome. This study was devoted understanding potential therapeutic roles inflammasome neurodegeneration occurring concomitant with and its progression emotional disorders.To test impact innate immune...
Neurogenesis is a complex process which governs embryonic brain development and importants for plasticity throughout the whole life. Postnatal neurogenesis occurs in neurogenic niches that regulate processes of proliferation differentiation stem progenitor cells under action stimuli trigger mechanisms neuroplasticity. Cells glial endothelial origin are key regulators neurogenesis. It known physiological neurogeneses crucial memory formation, whereas reparative provides partial repair altered...
Spinocerebellar ataxia type 1 (SCA1) is a debilitating neurodegenerative disorder of the cerebellum and brainstem. Memantine has been proposed as potential treatment for SCA1. It blocks N-methyl-D-aspartate (NMDA) receptors on neurons, reduces excitotoxicity decreases neurodegeneration in Alzheimer models. However, cerebellar diseases, value memantine still unclear. We investigated effects motor performance synaptic transmission mouse model where mutant ataxin specifically targeted to glia....
Cerebellar Purkinje cells (PCs) express two members of the classical protein kinase C (cPKC) subfamily, namely, PKCα and PKCγ. Previous studies on PKCγ knockout (KO) mice have revealed a critical role in pruning climbing fibers (CFs) from PCs during development. The question remains as to why only not is involved CF synapse elimination PCs. To address this question, we assessed expression levels wild-type (WT) KO using PC-specific quantitative real-time reverse transcription-polymerase chain...
All anatomical elements contributing to the blood-brain barrier (BBB) play a crucial role in maintaining permeability and CNS homeostasis under physiological/pathological conditions.These are endothelial cells, pericytes, astroglia, neurons that known as neurovascular unit (NVU).Being integral system, NVU contributes regulation of neuroplasticity, neurogenesis, intercellular communications BBB.Brain capillary cells (BCEC) very important part NVU.In this review, we discuss critical BCEC ion...
Alzheimer's disease is characterized by the loss of neurons, accumulation intracellular neurofibrillary tangles and extracellular amyloid plaques in brain. However, there are contradicting data on differences neurogenesis at onset or before formation plaques. As awareness importance pre-symptom phase neurodegenerative diseases grows context early diagnosis pathogenesis, we analyzed critical periods adult hippocampal an stage under action soluble Ab1-42 beta-amyloid. The proliferation,...
Astrogliosis is a pathological process that affects the density, morphology, and function of astrocytes. It common feature brain trauma, autoimmune diseases, neurodegeneration including spinocerebellar ataxia type 1 (SCA1), poorly understood neurodegenerative disease. S100β Ca2+ binding protein. In SCA1, excessive excretion by reactive astrocytes its uptake Purkinje cells has been demonstrated previously. Under conditions, extracellular concentration stimulates production proinflammatory...
The patch-clamp (PC) technique is the gold standard in studying processes that occur on membranes of excitable cells, both physiological condition and pathology. However, gaining this unique information associated with certain difficulties. The very labor intensive requires highly qualified specialists expensive equipment, which greatly limits its introduction into routine practice a neurobiological laboratory. This article discusses main advantages disadvantages of PC as well tendencies...
Memantine is an FDA approved drug for the treatment of Alzheimer's disease. It reduces neurodegeneration in hippocampus and cerebral cortex through inhibition extrasynaptic NMDA receptors patients mouse models. Potentially, it could prevent other brain areas caused by diseases. We previously used memantine to functional damage retain morphology cerebellar neurons Bergmann glia optogenetic model spinocerebellar ataxia type-1 (SCA1). However, before suggesting wider use clinics, its side...