- Planarian Biology and Electrostimulation
- Marine Ecology and Invasive Species
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience, Education and Cognitive Function
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Ion Transport and Channel Regulation
- Developmental Biology and Gene Regulation
- Plant and Biological Electrophysiology Studies
- Educational theories and practices
- Developmental and Educational Neuropsychology
- Child and Adolescent Psychosocial and Emotional Development
- Caveolin-1 and cellular processes
- Educational Innovations and Technology
- Health, Education, and Physical Culture
- Animal Genetics and Reproduction
- Fetal and Pediatric Neurological Disorders
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- Barrier Structure and Function Studies
- Medieval European Literature and History
- 3D Printing in Biomedical Research
- Hedgehog Signaling Pathway Studies
- Cerebrospinal fluid and hydrocephalus
- Marine Biology and Environmental Chemistry
Universitat de Barcelona
2015-2024
Institut de Biologia Evolutiva
2019-2023
Ministerio de Agricultura, Pesca y Alimentación
2014
Universidad de Valladolid
2005
University of Oxford
1996
Universidade de São Paulo
1970
Abstract Early in development, the behavior of neuroepithelial cells is controlled by several factors, which act a developmentally regulated manner. Diffusible factors are secreted locally neuroepithelium itself, although other nearby structures may also be involved. Evidence suggests physiological role for cerebrospinal fluid development brain. Here, using organotypic cultures chick embryo explants from mesencephalon, we show that vitro not able to self‐induce cell survival, replication,...
During early stages of embryo development, the brain cavity is filled with embryonic cerebrospinal fluid (E-CSF), a complex containing different protein fractions that contributes to regulation survival, proliferation and neurogenesis neuroectodermal stem cells. Using 2-DE, sequencing database searches, we identified analyzed proteome E-CSF from chick embryos (Gallus gallus). We 26 gene products, including proteins related extracellular matrix, associated osmotic pressure metal transport,...
During early stages of embryo development, the brain cavity is filled with Embryonic Cerebro-Spinal Fluid, which has an essential role in survival, proliferation and neurogenesis neuroectodermal stem cells. We identified analyzed proteome Fluid from rat embryos (Rattus norvegicus), includes proteins involved regulation Central Nervous System development. The comparison between mammalian avian proteomes reveals great similarity, but also greater complexity some protein groups. pattern...
Abstract Embryonic‐cerebrospinal fluid (E‐CSF) plays crucial roles in early brain development including the control of neurogenesis. Although FGF2 and lipoproteins present E‐CSF have previously been shown to be involved neurogenesis, main factor triggering this process remains unknown. contains all‐trans‐retinol retinol‐binding protein synthesis retinoic acid (RA), a neurogenesis inducer. In chick embryo brain, only mesencephalic‐rombencephalic isthmus (IsO) is able synthesize RA. Here we...
Early in development, the behavior of neuroepithelial cells is controlled by several factors acting a developmentally regulated manner. Recently it has been shown that diffusible contained within embryonic cerebrospinal fluid (CSF) promote cell survival, proliferation, and neurogenesis mesencephalic explants lacking any known organizing center. In this paper, we show + isthmic organizer cultured only with basal medium do not express typically expressed or genes analyzed (otx2 fgf8,...
Embryonic cerebrospinal fluid (E-CSF) is involved in the regulation of survival, proliferation and neurogenesis neuroectodermal progenitor cells, as well control mesencephalic gene expression collaboration with isthmic organizer. Recently, we showed presence retinol-binding protein (RBP) within E-CSF proteome. RBP an all-trans retinol carrier, a molecule that can be metabolized into retinoic acid, morphogen central nervous system (CNS) morphogenesis patterning. Here demonstrate analyse...
Abstract During development, embryonic cerebrospinal fluid(E‐CSF) is involved in cell survival, proliferation, and neurogenesis of the neuroepithelial progenitor cells. We have recently identified a complex pattern proteins chick rat E‐CSF, which include apolipoproteins. Apolipoproteins play critical role function lipoproteins by interacting with receptors to deliver lipid cargo target However, these E‐CSF apolipoproteins unclear. Here, we characterized lipoprotein profile analyzed its...
Farm tractor rollovers are associated with a major proportion of injuries and deaths in agriculture. Rollover protective structures (ROPS) drivers using seat belts have been proven to reduce 99...
During limb outgrowth, Shh, Fgf4, and Fgf8 act as signals controlling growth patterning. Because these genes are expressed in the bud other known signalling centers, we have explored relationships between expression of during mouse development using double situ hybridization. Within node domains contact each other, whereas floor plate domain does not that Shh. The relative temporal order gene varies different centers. spatial Fgf8, Shh suggests conservation molecular mechanisms organizing...
Abstract In vertebrates, brain development takes place at the expanded anterior end of neural tube. After closure neuropore, wall forms a physiologically sealed cavity that encloses embryonic cerebrospinal fluid (E‐CSF), complex and protein‐rich fluid. E‐CSF has several crucial roles in anlagen development. this respect, during initiation neurogenesis, increases volume cavities account for 70% total growth primordium, are accompanied by parallel increase volume. Recently, we reported...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...
Durante estas dos últimas décadas, los estudios en neurociencia y cognitiva han estado aportando datos muy interesantes sobre cómo se construye aprende el cerebro. Aplicados a la educación, lo que viene llamar neuroeducación, deben dejar de ser una disciplina estudiada solo contextos neurocientíficos pedagógicos para llegar toda sociedad, todas aquellas personas interesadas aprendizajes sus hijos e hijas suyos propios. Este artículo pretende aproximar al lector 5 principios básicos...