A5101798624- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Metabolism and Genetic Disorders
- Neurological diseases and metabolism
- Aluminum toxicity and tolerance in plants and animals
- Porphyrin Metabolism and Disorders
- Prion Diseases and Protein Misfolding
- Acute Ischemic Stroke Management
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Cerebrovascular and genetic disorders
- Electrochemical Analysis and Applications
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- HIV Research and Treatment
- Infectious Encephalopathies and Encephalitis
- Extraction and Separation Processes
- Iron Metabolism and Disorders
- Genetic Neurodegenerative Diseases
- Metalloenzymes and iron-sulfur proteins
- Pharmacological Effects and Toxicity Studies
- Biomarkers in Disease Mechanisms
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Autopsy Techniques and Outcomes
Institute of Psychiatry and Neurology
2014-2024
Icahn School of Medicine at Mount Sinai
2021-2024
New York Stem Cell Foundation
2024
University of Miami
2016-2017
Abstract Background MRI is a sensitive method for the assessment of brain abnormalities in Wilson disease, that is, T 2 hyperintensities, hypointensities, and atrophy, but validated scoring system classification radiological severity lacking. The objective this study was to develop validate visual rating scale disease. Methods proposed disease consists acute toxicity chronic damage subscores from predefined structures. former, calculated by summing scores hyperintensities (excluding...
Energetic regulation at the blood-brain barrier is critical for maintaining its integrity, transport capabilities, and brain demands glucose. However, underlying mechanisms that regulate these processes are still poorly explored. We recently characterized protein occludin as a NADH oxidase demonstrated influence on expression activation of histone deacetylase SIRT-1. Because SIRT-1 works in concert with AMP-activated kinase (AMPK) (AMPK), we investigated impact this metabolic switch. Here...
Clinical scales and neuroimaging are used to monitor nervous system injury in Wilson's disease, while data on serum markers scarce.To investigate whether concentrations of neurofilament light chain (sNfL) correlate with brain disease patients.In 61 treatment-naïve patients, the Unified Disease Rating Scale a validated semiquantitative magnetic resonance imaging scale were compared sNfL.Concentrations sNfL significantly higher patients neurological presenting other forms (39.7 ± 73.4 pg/mL...
HIV-1 infection and methamphetamine (METH) abuse frequently occur simultaneously may have synergistic pathological effects. Although HIV-positive/active METH users been shown to higher HIV viral loads experience more severe neurological complications than non-users, the direct impact of on its link development neurocognitive alternations are still poorly understood. In present study, we hypothesized that impacts neural progenitor cells (NPCs) by a mechanism encompassing NFκB/SP1-mediated LTR...
In Wilson's disease (WD), early neurological deterioration after treatment initiation is associated with poor outcomes; however, data on this phenomenon are limited. Our study analysed the frequency and risk factors of in WD.Early deterioration, within 6 months from diagnosis, was defined based Unified Disease Rating Scale (UWDRS): any increase part II or an ≥ 4 III. total, 61 newly diagnosed WD patients were included. UWDRS scores, brain magnetic resonance imaging (MRI) copper metabolism...
Significant intercenter variability in quality of care and stroke outcomes was found many countries. The aim the study to compare acute ischemic centers participating Polish National Stroke Prevention Treatment Registry.The World Health Organization Stepwise Approach Surveillance-based questionnaire used collect data on patients admitted between December 1, 2001, July 31, 2002. To ensure quality, only reporting representative sample were analyzed. Ischemic patient characteristics,...
Although brain atrophy is common in neurological Wilson's disease, longitudinal studies are lacking.The objective of this study was to measure rate and relate it the change impairment disease.We included patients with imaging done at diagnosis least 12 months later. The measured as percentage ventricular volume, whereas scored on Unified Disease Rating Scale.Of 57 patients, 36 had presentation, 17 hepatic 4 were presymptomatic. annualized significantly greater presentation than other (P =...
Mitochondrial membrane protein-associated neurodegeneration is an autosomal-recessive disorder caused by C19orf12 mutations and characterized iron deposits in the basal ganglia.The aim of this study was to quantify concentrations deep gray matter structures using quantitative susceptibility mapping MRI characterize metabolic abnormalities pyramidal pathway 1 H MR spectroscopy clinically manifesting patients asymptomatic gene mutation heterozygous carriers.We present data 4 affected (mean...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...