A5058248337- Pancreatic function and diabetes
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Barrier Structure and Function Studies
- Microbial infections and disease research
- Vector-borne infectious diseases
- Skin Protection and Aging
- Neurological Disease Mechanisms and Treatments
- Diet, Metabolism, and Disease
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Plant tissue culture and regeneration
- Herpesvirus Infections and Treatments
- Neuroblastoma Research and Treatments
- Congenital heart defects research
- Down syndrome and intellectual disability research
- Intestinal Malrotation and Obstruction Disorders
- Pharmacological Effects of Medicinal Plants
- Angiogenesis and VEGF in Cancer
- Hemophilia Treatment and Research
- Wound Healing and Treatments
- Metabolism, Diabetes, and Cancer
- melanin and skin pigmentation
- Folate and B Vitamins Research
Sophia Genetics (Switzerland)
2023-2024
University of Zurich
2013-2022
Justus-Liebig-Universität Gießen
2017-2018
Swiss Integrative Center for Human Health
2017
University Medical Center Freiburg
2013-2015
Pericytes play essential roles in blood-brain barrier integrity and their dysfunction is implicated neurological disorders such as stroke although the underlying mechanisms remain unknown. Hypoxia-inducible factor-1 (HIF-1), a master regulator of injury responses, has divergent different cells especially during stress scenarios. On one hand HIF-1 neuroprotective but on other it induces vascular permeability. Since pericytes are critical for stability, we asked if pericyte signaling impacts...
Ways to prevent disease-induced vascular modifications that accelerate brain damage remain largely elusive. Improved understanding of perivascular cell signalling could provide unparalleled insight as these cells impact stability and functionality the neurovascular unit a whole. Identifying key drivers astrocyte pericyte responses modify cell-cell interactions crosstalk during injury is key. At cellular level, injury-induced outcomes are closely entwined with activation hypoxia-inducible...
The complex process of skin aging results in noticeable changes, including decreased collagen content, reduced elasticity, and hydration. Interventions to preserve or restore collagen, a key structural protein, may help counteract these signs. concept "beauty from within” through nutritional supplements is growing interest, particularly the use plant-based alternatives animal-derived synthetic collagen. This study investigated anti-aging potential an extract Moldavian dragonhead...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...
Abstract Background Astrocytes (AC) are essential for brain homeostasis. Much data suggests that AC support and protect the vascular endothelium, but increasing evidence indicates during injury conditions they may lose their supportive role resulting in endothelial cell activation BBB disturbance. Understanding triggers flip this switch would provide invaluable information designing new targets to modulate compartment. Hypoxia-inducible factor-1 (HIF-1) has long been assumed be a culprit...
The global increase in life expectancy has led to a growing elderly population, which places significant burden on healthcare systems. As result, there is interest improve healthspan and promote healthy aging with accessible means, such as nutrition lifestyle interventions. skin, the body's largest organ first line of defense against environmental stressors, particularly vulnerable due both intrinsic extrinsic factors. Various molecular biochemical changes can drive skin aging, including...
"Mycoplasma haemofelis" and "Candidatus Mycoplasma turicensis" are feline hemoplasmas that induce hemolytic anemia. Protection from homologous re-challenge was recently demonstrated in cats recovered primary infection. Here, we determined if "Cand. M. infection were protected against infections with the more pathogenic haemofelis. Ten specified pathogen-free exposed to Five of ten had bacteremia (group A), five naïve controls B). No cross-protection observed. By contrast,...
Stressed, damaged or very aged skin is predominantly characterized by a malfunctioning barrier. Underlying barrier malfunction reduced defective calcium gradient in the epidermis. Consequently, replenishing compromised skin's stores with topical could be potential therapeutic approach.
Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging general health. Phytochemicals in centenarians’ diets, such as those found Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan related species, has demonstrated anti-inflammatory neuroprotective...
Skin aging is a complex, multifaceted process influenced by both intrinsic and extrinsic factors. Understanding the molecular mechanisms underlying skin crucial for developing effective anti-aging strategies. Dermal stem cells play pivotal role in maintaining homeostasis, but their functionality compromised with aging. This study investigated impact of on dermal explored potential natural extracts modulating biological characteristics. Using bulk RNA barcoding sequencing (BRB-seq), we...
To determine whether the current <sup>18</sup>F-FDG PET response criterion for skeletal involvement in Hodgkin lymphoma (HL) is suitable, we performed a systematic evaluation of different types and their on after 2 cycles chemotherapy (PET-2). A secondary objective was to observe influence initial uptake intensity (measured as qPET) metabolic tumor volume (MTV) lesions PET-2 response. <b>Methods:</b> The scans 1,068 pediatric HL patients from EuroNet-PHL-C1 trial were evaluated by central...
Introduction: The intracellular protein NUPR1 (alias p8) reduces tissue damage during acute pancreatitis, and its expression is enriched in pancreatic islets. Therefore, we hypothesized that may exert protective mechanisms the endocrine pancreas under inflammatory diabetogenic stress. This was investigated transgenic mice with β-cell-specific overexpression (Tg).
Introduction: We previously demonstrated that transgenic mice with beta cell-specific overexpression of Nupr1 (Nupr1-Tg) are resistant to multiple low-dose streptozotocin (STZ) and/or high fat diet (HFD). Preserved insulin secretion Nupr-Tg islets in vivo was associated reduced NF-kB activation and less lymphocyte infiltration. The pro-inflammatory cytokine IL-1beta is well known promote cell apoptosis inhibit via NF-kB. Therefore, we investigated the response its physiologic receptor...
Introduction: A current hypothesis considers type 2 diabetes as a result of over nutrition-induced local inflammation leading to insulin resistance, secretory dysfunction and finally pancreatic beta cell loss. The intracellular protein p8 has been shown reduce tissue damage during acute pancreatitis. To investigate its role in the endocrine pancreas we generated transgenic mice with cell-specific overexpression (Tg).
Introduction: High caloric malnutrition promotes local cellular proinflammatory activation leading to insulin resistance in peripheral tissues, secretory dysfunction and loss, finally type 2 diabetes. The intracellular protein p8 has been shown reduce exocrine tissue damage during pancreatitis. To investigate its role the endocrine pancreas we generated transgenic mice with beta cell-specific overexpression. demonstrate substantially improved glucose tolerance high fat diet (HFD) and/or...