A5069912320- Barrier Structure and Function Studies
- Bipolar Disorder and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Neurological Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Intensive Care Unit Cognitive Disorders
- Caveolin-1 and cellular processes
- Neuroscience of respiration and sleep
- Multiple Sclerosis Research Studies
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Trauma and Emergency Care Studies
- vaccines and immunoinformatics approaches
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Obstructive Sleep Apnea Research
- Adipose Tissue and Metabolism
Columbia University Irving Medical Center
2024
Koç University
2019-2022
Cornell University
2022
Ondokuz Mayıs University
2019
Istanbul Medeniyet University
2019
Bezmiâlem Vakıf Üniversitesi
2019
Istanbul University
2016-2018
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement...
Bipolar disorder (BD) patients have recently been shown to exhibit increased proinflammatory cytokine levels indicating the role of inflammation in this disease. As inflammatory responses often include complement level alterations and production is influenced by cytokines, we aimed find out whether system activated BD a time-dependent manner factors are involved pathogenesis.Serum C4, factor B, sC5b-9 neuron-specific enolase were measured enzyme-linked immunosorbent assay, whereas peripheral...
Soluble ACE2 (sACE2) decoys are promising agents to inhibit SARS-CoV-2, as their efficiency is unlikely be affected by escape mutations. However, success limited relatively poor potency. To address this challenge, multimeric sACE2 consisting of SunTag or MoonTag systems developed. These extremely effective in neutralizing SARS-CoV-2 pseudoviral and clinical isolates, perform better than the dimeric trimeric sACE2, exhibit greater 100-fold neutralization efficiency, compared monomeric sACE2....
SUMMARY The blood-brain barrier (BBB), formed by specialized brain microvascular endothelial cells (BMECs), regulates function in health and disease. In vitro modeling of the human BBB is limited lack robust hiPSC protocols to generate BMECs. Here, we report generation, transcriptomic functional characterization reprogrammed BMECs (rBMECs) combining differentiation into BBB-primed reprogramming with two transcription factors FOXF2 ZIC3. rBMECs express a subset gene repertoire including tight...
Intravenous (IV) immunoglobulin (Ig) treatment is known to alleviate behavioral deficits and increase survival in the experimentally induced model of sepsis. To delineate mechanisms by which IVIg prevents neuronal dysfunction, an array immunological apoptosis markers was investigated.Sepsis cecal ligation perforation (CLP) rats. The animals were divided into five groups: sham, control, CLP + saline, G (IgG) (250 mg/kg, iv), immunoglobulins enriched with M (IgGAM) iv). Blood brain samples...
Fluids and Barriers of the CNS 2017, 14(Supp 2):A3The loss blood-brain barrier (BBB) integrity primarily occurs in cerebral venules veins during acute hypertensive conditions.Methyl-beta-cyclodextrin (MBCD) causes cholesterol depletion from cell plasma membrane leads to caveolar transport disruption.The present study was intended examine effects MBCD 14(Suppl 2):27 on functional structural properties type brain microvessels angiotensin (ANG) II-induced hypertension rats.The experimental...
The increase in the circulatory cytokine levels observed patients with bipolar disorder (BD) may imply involvement of inflammation pathogenesis mood disorders. However, association between inflammatory process and stage severity illness is not well understood. In this study, our aim was to investigate neuroinflammation disease progression clinical course BD.IL-6, TNF-α, IL-1 receptor antagonist (IL-1RA), neuronspecific enolase (NSE) S100B were measured by ELISA plasma samples at early-stage...
Prolactin has been discussed as a factor likely to play mediating role in multiple sclerosis (MS). Our aim was investigate the possible association between prolactin production and clinical features of autoimmune demyelinating central nervous system disorders.Serum levels 255 MS patients, 19 neuromyelitis optica (NMO) 15 clinically isolated syndrome (CIS) 240 healthy controls were measured by heterogeneous sandwich magnetic separation assay.MS NMO cohorts had significantly higher number...
Obstructive sleep apnea syndrome (OSAS) is associated with intermittent episodes of hypoxia, endothelial dysfunction and cardiovascular problems. Our aim was to investigate whether OSAS-related hypoxia alters the expression rho-associated protein kinase (ROCK), a marker chronic dysfunction.ROCK1 ROCK2 levels were measured by immunoblotting in peripheral blood mononuclear cells (PBMC) 47 OSAS patients 17 healthy controls.OSAS showed significantly lower PBMC ROCK1 than controls morning, but...
Abstract Astrocytes are key regulators of central nervous system (CNS) homeostasis, and their dysfunction is implicated in neurological neurodegenerative disorders. Here, we describe a two‐step protocol to generate astrocytes from human induced pluripotent stem cells (hiPSCs) using bankable neural progenitor cell (NPC) intermediate, followed by low‐density passaging overexpression the gliogenic transcription factor NFIA . A NPC intermediate allows for facile differentiation into both...
Aim: The aim of the study was to determine how addition a DNA oligonucleotide cargo 3-nm gold glyconanoparticles would affect tissue distribution. Methods: Gold with 1-6 covalently bound oligonucleotides (40 nt dsDNA) were injected into rats and allowed circulate for 10 min. Organs harvested quantitated by inductively coupled plasma mass spectrometry. Cellular localization nanocarriers determined electron microscopy. Results & conclusion: Addition prevented in kidney but increased liver...
ABSTRACT Histopathological studies of multiple sclerosis (MS), a demyelinating disease the central nervous system (CNS), and its animal model, experimental autoimmune encephalomyelitis (EAE), have found newly formed leaky vessels in demyelinated acute chronic plaques, addition to blood-brain barrier (BBB) damage existing vessels, that exacerbate pathology by increasing infiltration immune cells. Which vessel subtypes signaling pathways generate these aberrant is poorly understood. Using...
Introduction There is growing evidence about neuroinflammation in the aetiopathogenesis of bipolar disorder. Early diagnosis and intervention strategies are thought to be excessively important lately. Objectives To check levels early stage disorder explore associations with clinical variables. Aims We aimed evaluate inflammation neurodegeneration findings Methods Serum interleukin 1-receptor antagonist (IL-1Ra), 6 (IL-6), tumor necrosis factor-alpha (TNF-α), high sensitive C reactive protein...
Abstract Soluble ACE2 (sACE2) decoy receptors are promising agents to inhibit SARS-CoV-2, as their efficiency is less likely be affected by common escape mutations in viral proteins. However, success may limited relatively poor potency. To address this challenge, we developed a large library of sACE2 fusion proteins, generated with several protease inhibitors or multimerization tags. Among these decoys, multimeric consisting SunTag MoonTag systems, which were originally utilized for signal...