A5071668643- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Antifungal resistance and susceptibility
- Neurological Complications and Syndromes
- Cardiac and Coronary Surgery Techniques
- Family and Patient Care in Intensive Care Units
- COVID-19 and healthcare impacts
- Pharmacological Effects of Natural Compounds
- Acute Kidney Injury Research
- Airway Management and Intubation Techniques
- Vagus Nerve Stimulation Research
- Clinical Nutrition and Gastroenterology
- Neuroinflammation and Neurodegeneration Mechanisms
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pediatric Pain Management Techniques
- Anesthesia and Neurotoxicity Research
Istanbul University
2016-2025
Türk Anesteziyoloji ve Reanimasyon Derneği
2018-2023
Türkisch-Deutsche Universität
2019-2023
Haseki Eğitim ve Araştırma Hastanesi
2022
Afyon Kocatepe University
2018
Karadeniz Technical University
2018
Adıyaman University
2018
Amerikan Hastanesi
2018
Sakarya University
2018
Izmir University
2018
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement...
Gastrointestinal (GI) motility disorders in intensive care patients remain relatively unexplored. Nowadays, the frequency, risk factors and complications of GI dysfunction during enteral nutrition (EN) become more questionable.
Background/Aim: Sepsis-induced acute kidney injury is a fatal, potentially reversible clinical condition. C5a receptor (C5aR) has been implied to play pivotal roles in both autophagy and sepsis-induced organ dysfunction. The aim of this study was demonstrate the effects intravenous immunoglobulin preparations on expression markers investigate possible association between C5aR tissue septic rats. Materials Methods: Sepsis induced by cecal ligation perforation (CLP) rats, which were divided...
Objective:The defective interplay between coagulation and inflammation may be the leading cause of intravascular organ dysfunction in coronavirus disease-19 (COVID-19) patients.Abnormal profiles were reported to associated with poor outcomes.In this study, we assessed prognostic values antithrombin (AT) activity levels impact fresh frozen plasma (FFP) treatment on outcome. Materials Methods:Conventional parameters as well AT outcomes 104 consecutive critically ill acute respiratory distress...
Sepsis-induced brain dysfunction (SIBD) has been neglected until recently due to the absence of specific clinical or biological markers. There is increasing evidence that sepsis may pose substantial risks for long term cognitive impairment.To find out and inflammatory factors associated with acute SIBD serum levels cytokines, complement breakdown products neurodegeneration markers were measured by ELISA in sera 86 patients 33 healthy controls. Association between these test results was...
Objectives To evaluate the effect of adjunct treatment with Octagam, an intravenous immunoglobulin (IVIG) product, on clinical outcomes and biomarkers in critically ill COVID-19 patients.
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Intravenous (IV) immunoglobulin (Ig) treatment is known to alleviate behavioral deficits and increase survival in the experimentally induced model of sepsis. To delineate mechanisms by which IVIg prevents neuronal dysfunction, an array immunological apoptosis markers was investigated.Sepsis cecal ligation perforation (CLP) rats. The animals were divided into five groups: sham, control, CLP + saline, G (IgG) (250 mg/kg, iv), immunoglobulins enriched with M (IgGAM) iv). Blood brain samples...
Candida species are the primary cause of fungal infections in intensive care units (ICUs). Despite increasing prevalence Candida-related infections, monitoring progression these from colonization COVID-19 ICU patients lacks sufficient information. This study aims prospectively to compare 62 and 60 non-COVID-19 admission discharge terms development, rates, isolated species, risk factors, during hospitalization. A total 1464 samples were collected at specific time intervals various body sites...
Cognitive dysfunction in the early postoperative course is common for elderly population. Anesthetic management may affect cognitive decline. Effective analgesia, recovery and modulation of stress response are advantages neuraxial blocks. This study aims to compare effects general anesthesia combination with epidural analgesia (POCD). We hypothesized that block combined (GA) would have a favorable influence on POCD prevention.Patients above 60 years undergoing non-cardiac surgery were...
Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis that may lead to cognitive decline. Our aim was investigate whether the neurofilament light chain (NFL) and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) could be utilized as prognostic biomarkers in SAE.In this prospective observational study, baseline serum levels sTREM2 cerebrospinal fluid (CSF) NFL were measured by ELISA 11 SAE patients controls. Patients underwent daily neurological...
The prognostic factors for COVID-19 in patients with chronic kidney disease (CKD) are uncertain. We conducted a study to compare clinical and features between hospitalized without CKD.Fifty-six stage 3-5 CKD propensity score-matched fifty-six were included the study. Patients followed-up at least fifteen days or until death after diagnosis. endpoints from all causes, development of acute injury (AKI) cytokine release syndrome respiratory failure, admission intensive care unit (ICU).All...
We aim to demonstrate behavioral alterations in a sepsis model using intravenous (IV) immunoglobulin G (IgG) and immunoglobulins enriched with IgA IgM (IgGAM).We divided 48 Wistar albino rats into five groups: control group, sham-operated group (only antibiotic treatment), cecal ligation puncture (CLP) (CLP plus IgG (250 mg/kg IV IgG) IgGAM IgGAM). Intravenous were given 5 min after the CLP procedure. Experimental animals put three tasks 10, 30 60 days surgery; evaluate locomotor activity,...
Abstract Introduction Acute kidney injury (AKI) is linked to disease severity and prognosis in patients with coronavirus 2019 (COVID-19), mortality increases even milder stages. This study primarily investigated the effects of continuous renal replacement therapy (CRRT) timing on intensive care unit (ICU) COVID-19 acute respiratory distress syndrome (ARDS) AKI. Secondary goals were secondary for ICU, days without life support treatment, change post-CRRT day biomarker levels, length ICU...
A disfunção cognitiva pós‐operatória (DCPO) é um resultado adverso cirúrgico que mais comum após cirurgias cardíacas abertas. O objetivo deste estudo foi investigar o papel dos níveis de glicose no sangue rigorosamente controlados durante a cirurgia coronariana declínio cognitivo precoce e tardio. Foram randomizados em dois grupos 40 pacientes acima 50 anos submetidos à eletiva. No grupo "controle rigoroso" (GI), glicemia mantida entre 80‐120 mg.dL−1; enquanto "liberal" (GII), variou 80‐180...
Postoperative cognitive dysfunction (POCD) is an adverse outcome of surgery that more common after open heart procedures. The aim this study to investigate the role tightly controlled blood glucose levels during coronary artery on early and late decline. 40 patients older than 50 years undergoing elective were randomized into two groups. In “Tight Control” group (GI), glycemia was maintained between 80 120 mg dL−1 while in “Liberal” (GII), it ranged 80–180 dL−1. A neuropsychological test...