A5101401010- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Emergency and Acute Care Studies
- High Altitude and Hypoxia
- Travel-related health issues
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- Antifungal resistance and susceptibility
- Neuroscience of respiration and sleep
- Cystic Fibrosis Research Advances
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Climate Change and Health Impacts
- Sepsis Diagnosis and Treatment
- Tracheal and airway disorders
- Complement system in diseases
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Influenza Virus Research Studies
Hospital General San Jorge
2013-2024
Hospital San Agustin
2020
The University of Texas Health Science Center at San Antonio
2016-2020
Universidad de La Sabana
2018
Instituto Aragonés de Ciencias de la Salud
2015
Instituto Politécnico Nacional
2012
Hospital Clínico Universitario de Valencia
2011
Universidad de Zaragoza
2009-2010
Hospital de Cruces
2003-2005
Sociedad Española de Neumología y Cirugía Torácica
2003
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement...
Aim. To evaluate the effectiveness of omalizumab in non-atopic asthma. Methods. Using data from a multicenter registry severe asthma, we evaluated and compared clinical outcome 29 omalizumab-treated asthmatics with 266 allergic asthmatics. Effectiveness was assessed by considering exacerbations, pulmonary function, Global Evaluation Treatment (GETE) scale, Asthma Control Test (ACT). Results. Omalizumab demonstrated significant improvement status as measured GETE, which rose 1.6 ± 1.1 to 2.8...
Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated severe sepsis hospitalized CAP. Results We performed a prospective multicenter cohort study 13 Spanish hospital, 4070 CAP patients, 1529 whom (37.6%) presented sepsis. was independently older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07–1.61), chronic obstructive...
Some studies highlight the association of better clinical responses with adherence to guidelines for empiric treatment community-acquired pneumonia (CAP), but little is known about factors that influence this adherence.Our objectives were identify influencing CAP, and evaluate impact on outcome.We studied 1,288 patients CAP admitted 13 Spanish hospitals. Collected variables included patients' demographic data, initial severity disease, antibiotic treatment, specialty training status...
Community-acquired pneumonia (CAP) in the elderly has increased as a consequence of an overall increase population. A controversy about aetiology and outcome CAP this population still exists more epidemiological studies are needed. prospective, 12-month, multicentre study was carried out to assess clinical characteristics, aetiology, evolution prognostic factors patients (≥65 yrs) admitted hospital for CAP. The included 503 (age 76±7 yrs). picture lasted ≤5 days 318 (63%) main features were...
The natural history of the resolution infectious parameters in patients with community-acquired pneumonia (CAP) is not completely known. aim our study was to identify those factors related host characteristics, severity pneumonia, and treatment that influence clinical stability.In a prospective, multicenter, observational study, we observed 1424 CAP who were admitted 15 Spanish hospitals. main outcome variable number days needed reach stability (defined as temperature <or=37.2 degrees C,...
Processes of care and adherence to guidelines have been associated with improved survival in community-acquired pneumonia (CAP). In sepsis, bundles processes also increased survival. We aimed audit compliance guideline-recommended its impact on outcome hospitalised CAP patients sepsis. prospectively studied 4,137 13 hospitals. The evaluated were antibiotic prescription guidelines, first dose within 6 h oxygen assessment. Outcome measures mortality length stay (LOS). Oxygen assessment was...
To determine the impact of initial antimicrobial choice on 30-day mortality rate in patients with community-acquired pneumonia due to Streptococcus pneumoniae (CAP-SP), a prospective, observational study was conducted 35 Spanish hospitals. A total 638 CAP-SP were identified. Antimicrobials chosen by attending physician. Patients grouped into following categories: β-lactam monotherapy (n = 251), macrolide 37), plus 198), levofloxacin alone/combination 48), and other combinations 104). The...
Inherited variability in host immune responses influences susceptibility and outcome of Influenza A virus (IAV) infection, but these factors remain largely unknown. Components the innate response may be crucial first days infection. The collectins surfactant protein (SP)-A1, -A2, -D mannose-binding lectin (MBL) neutralize IAV infectivity, although only SP-A2 can establish an efficient neutralization poorly glycosylated pandemic strains. We studied role polymorphic variants at genes MBL...
Rationale: Detection of the C-polysaccharide Streptococcus pneumoniae in urine by an immune-chromatographic test is increasingly used to evaluate patients with community-acquired pneumonia.Objectives: We assessed sensitivity and specificity this largest series cases date logistic regression models determine predictors positivity hospitalized pneumonia.Methods: performed a multicenter, prospective, observational study 4,374 pneumonia.Measurements Main Results: The urinary antigen was done...
Genetic variability of the pulmonary surfactant proteins A and D may affect clearance microorganisms extent inflammatory response. The genes these collectins (SFTPA1, SFTPA2 SFTPD) are located in a cluster at 10q21-24. objective this study was to evaluate existence linkage disequilibrium (LD) among genes, association with susceptibility outcome community-acquired pneumonia (CAP). We also studied effect genetic on SP-D serum levels. Seven non-synonymous polymorphisms SFTPA1, SFTPD were...
To assess the potential association of functional polymorphism rs1801274 in receptor IIa for Fc portion immunoglobin G (FcγRIIa) gene (FCGR2A-H131R) with susceptibility to and severity community-acquired pneumonia (CAP).Multicenter prospective observational study.Four university hospitals Spain.FCGR2A-H131R was determined 1,262 patients CAP 1,224 subject control group.Severe sepsis recorded 366 patients. No significant differences genotype or allele frequencies were seen among pneumococcal...
The role of mannose-binding lectin (MBL) deficiency ( MBL2 ; XA/O and O/O genotypes) in host defences remains controversial. surfactant proteins (SP)-A1, -A2 -D, other collectins whose genes are located near , part the first-line lung defence against infection. We analysed MBL on susceptibility to pneumococcal infection existence linkage disequilibrium (LD) among four genes. studied 348 patients with community-acquired pneumonia (P-CAP) 2,110 controls. A meta-analysis genotypes P-CAP...
ABSTRACT Background and objective The of this study was to evaluate the effect age comorbidities, smoking alcohol use on microorganisms in patients with community‐acquired pneumonia ( CAP ). Methods A prospective multicentre performed 4304 patients. We compared microbiological results, bacterial aetiology, smoking, abuse comorbidities three groups: young adults (<45 years), (45–64 years) seniors (>65 years). Results Bacterial aetiology identified 1522 (35.4%) In seniors, liver disease...