A5054205783- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Nosocomial Infections in ICU
- Lung Cancer Diagnosis and Treatment
- Smoking Behavior and Cessation
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Respiratory and Cough-Related Research
- Chronic Disease Management Strategies
- Trauma Management and Diagnosis
- Emergency and Acute Care Studies
- Tracheal and airway disorders
- Sarcoidosis and Beryllium Toxicity Research
- Health and Medical Education
- Nursing Diagnosis and Documentation
- Pediatric health and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Poisoning and overdose treatments
- Health and Lifestyle Studies
Hospital Universitario de Valme
2015-2024
Universidad de Sevilla
2014-2024
Sociedad Española de Neumología y Cirugía Torácica
2010-2018
Hospital Clínic de Barcelona
2014
Instituto Politécnico Nacional
2012
Hospital Arnau de Vilanova
2009
Respiratory Clinical Trials
2009
Hospital Universitario Virgen del Rocío
1997
<b>Background:</b> A study was undertaken to evaluate the clinical efficacy of 23-valent pneumococcal polysaccharide vaccine (PPV) in immunocompetent patients with chronic obstructive pulmonary disease (COPD). <b>Methods:</b> randomised controlled trial carried out 596 COPD mean (SD) age 65.8 (9.7) years, 298 whom received PPV. The main outcome radiographically proven community acquired pneumonia (CAP) or unknown aetiology after a period 979 days (range 20–1454). <b>Results:</b> There were...
The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial. To evaluate the prevalence and stability a high level eosinophils (≥300 cells·μL –1 ) its relationship to outcomes, we determined at baseline over 2 years 424 COPD patients (forced expiratory volume 1 s (FEV 60% predicted) 67 smokers without from CHAIN cohort, 308 BODE cohort. We related eosinophil levels exacerbations survival using Cox hazard analysis. In patients, 15.8% cohort 12.3% had...
Guidelines recommend defining chronic obstructive pulmonary disease (COPD) by airflow obstruction and other factors, but no studies have evaluated the ability of existing multicomponent indices to predict mortality up 10 years. We conducted a patient-based pooled analysis. Survival analysis C statistics were used determine best COPD index/indices according several construct variables varying time-points. Individual data 3633 patients from 11 cohorts collected, totalling experience 15 878...
Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated severe sepsis hospitalized CAP. Results We performed a prospective multicenter cohort study 13 Spanish hospital, 4070 CAP patients, 1529 whom (37.6%) presented sepsis. was independently older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07–1.61), chronic obstructive...
<h3>Introduction</h3> Healthcare-associated pneumonia (HCAP) is actually considered a subgroup of hospital-acquired due to the reported high risk multidrug-resistant pathogens in USA. Therefore, current American Thoracic Society/Infectious Diseases Society America guidelines suggest nosocomial antibiotic treatment for HCAP. Unfortunately, scientific evidence supporting this contradictory. <h3>Methods</h3> We conducted prospective multicentre case–control study Spain, comparing clinical...
Processes of care and adherence to guidelines have been associated with improved survival in community-acquired pneumonia (CAP). In sepsis, bundles processes also increased survival. We aimed audit compliance guideline-recommended its impact on outcome hospitalised CAP patients sepsis. prospectively studied 4,137 13 hospitals. The evaluated were antibiotic prescription guidelines, first dose within 6 h oxygen assessment. Outcome measures mortality length stay (LOS). Oxygen assessment was...
The Spanish guideline for COPD (GesEPOC) recommends treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator (FEE) (FECB). However, little is known on the distribution and outcomes of suggested phenotypes.We aimed determine these phenotypes, their relation one-year outcomes.We followed a cohort well-characterized patients up one-year. Baseline characteristics, health...
This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients clinical phenotypes identified by cluster analyses. Data from 2409 COPD of French/Belgian cohorts were analysed using analysis resulting in the identification subgroups, which relevance was determined comparing 3-year all-cause mortality. Classification and regression trees (CARTs) used develop an algorithm these subgroups. tested 3651 Cohorts Collaborative International Assessment...
Rationale: Detection of the C-polysaccharide Streptococcus pneumoniae in urine by an immune-chromatographic test is increasingly used to evaluate patients with community-acquired pneumonia.Objectives: We assessed sensitivity and specificity this largest series cases date logistic regression models determine predictors positivity hospitalized pneumonia.Methods: performed a multicenter, prospective, observational study 4,374 pneumonia.Measurements Main Results: The urinary antigen was done...
Introduction: there is still uncertainty about which aspects of cigarette smoking influence the risk Chronic Obstructive Pulmonary Disease (COPD). The aim this study was to estimate COPD as related duration use, intensity lifetime tobacco consumption, age initiation and years abstinence. Methods: we conducted an analytical cross-sectional based on data from EPISCAN-II (n=9,092). All participants underwent a face-to face interview post-bronchodilator spirometry performed. defined FEV1/FVC...
Abstract Background: Malignant pleural mesothelioma (MPM) results from malignant transformation of mesothelial cells. Past asbestos exposure represents a major risk factor for MPM and other benign disease. Soluble mesothelin-related peptides (SMRP) have been regarded as promising serum biomarker MPM. The aim this study was to investigate levels SMRP in nonmalignant asbestos-related Patients: Four groups patients were investigated: group 1 composed 48 healthy subjects, 2 177 with previous no...
Background FEV1 is universally used as a measure of severity in COPD. Current thresholds are based on expert opinion and not evidence. Objectives We aimed to identify the best (% predicted) dyspnea (mMRC) predict 5-yr survival COPD patients. Design Methods conducted patient-based pooled analysis eleven Spanish cohorts (COCOMICS). Survival analysis, ROC curves, C-statistics were compare (%) mMRC scale that survival. Results A total 3,633 patients (93% men), totaling 15,878 person-yrs....
Several composite markers have been proposed for risk assessment in chronic obstructive pulmonary disease (COPD). However, choice of parameters and score complexity restrict clinical applicability. Our aim was to provide validate a simplified COPD index independent lung function.The PROMISE study (n=530) used develop novel prognostic index. Index performance assessed regarding 2-year COPD-related mortality all-cause mortality. External validity tested stable exacerbated patients the ProCOLD,...