A5008917341- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Nursing Diagnosis and Documentation
- Emergency and Acute Care Studies
- Chronic Disease Management Strategies
- Pediatric health and respiratory diseases
- Inflammatory Biomarkers in Disease Prognosis
- Pleural and Pulmonary Diseases
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Renal and Vascular Pathologies
- Immune cells in cancer
- Immune Response and Inflammation
- Birth, Development, and Health
- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Organ Donation and Transplantation
- Renal and related cancers
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
Health Research Institute of the Balearic Islands
2019-2022
Hospital Universitario Son Espases
2016-2022
This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients clinical phenotypes identified by cluster analyses. Data from 2409 COPD of French/Belgian cohorts were analysed using analysis resulting in the identification subgroups, which relevance was determined comparing 3-year all-cause mortality. Classification and regression trees (CARTs) used develop an algorithm these subgroups. tested 3651 Cohorts Collaborative International Assessment...
Patients with chronic obstructive pulmonary disease (COPD) frequent exacerbations (ExCOPD) are commonly treated inhaled corticosteroids (ICS) and at risk of infections caused by potential pathogenic bacteria (PPB) including
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory commonly induced by cigarette smoke. The expression of miRNAs can be altered in patients with COPD and could used as biomarker. We aimed to identify panel bronchoalveolar lavage (BAL) differentiate from smokers non-smokers normal lung function. Accordingly, forty-five subjects classified COPD, smokers, (
Inhaled corticosteroids (ICS) use is associated with an increased risk of Pseudomonas aeruginosa (PA) infection in patients COPD. We aimed to evaluate the effects ICS on alveolar macrophages response PA COPD and without baseline treatment (COPD + ICS, respectively) as well smoker nonsmoker controls. To do so, cells were infected cotreated budesonide (BUD) or fluticasone propionate (FLU). The analysis NF-κB c-jun activity revealed a significant increase both factors BUD/FLU smokers but not...
<b>Introduction</b> Patients with fragile COPD (fCOPD), defined as those two or more hospital admissions in the last year, have a high consumption of health resources because frequent hospitalizations and emergency room (ER)visits. <b>Objective</b> To evaluate effectiveness comprehensive care management program (CCMP) for patients fCOPD on reductions ER visits. <b>Methods</b> In cohort study design, were recruited after discharge an exacerbation. assigned to groups:a nurse led CCMP fast...
<b>Introduction:</b> Severe uncontrolled asthma (SUA) is a heterogeneous condition currently managed using clinical characteristic and biomarkers such as allergic status blood eosinophil counts. We aimed to demonstrate that bronchoscopy(BC) bronchial biopsy(BB) are useful safe procedures in the assessment of SUA. <b>Methods:</b> Retrospective analysis with longitudinal follow up patients referred difficult clinic for biologic therapy. BC was performed when no clear relation allergy...
<b>Introduction:</b> COPD is currently considered a risk factor for lung cancer. The mechanisms of thise association between poorly understood. Biomarkers in body fluids (liquid biopsy) provide low-cost and non-invasive methods cancer detection prognosis. In this study we use microRNAs as biomarker. objectives were to develop panel miRNAs bronchoalveolar lavage (BAL) allowing us detect differentiate patients with LC from without smokers normal function LC. <b>Material methods:</b> 20...
<b>Background:</b> COPD with frequent exacerbations patients (COPDfe) are frequently treated inhaled corticosteroids (ICS) and also at risk for infections caused by potential pathogenic bacteria (PPB) including Pseudomonas aeruginosa (PsA). <b>Objectives:</b> To investigate the association between use of ICS PsA infection among COPDfe. <b>Methods:</b> case-controlled study longitudinal follow up that recruited COPDfe (≥2/year) after being discharged from hospital due to exacerbation 2012...
<b>Background</b> Histology is crucial for the multidisciplinary diagnosis of idiopathic interstitial pneumonias (IIP). Transbronchial cryobiopsy (TBC) has been demonstrated to be useful obtaining lung parenchyma; however its experience in IIP limited. <b>Objectives</b> To describe diagnostic yield and safety TBC study IIP. <b>Method</b> Prospective 23 outpatients TBC. All cases had typical clinical radiological features The endoscopic procedure was performed operating theatre using a...
The use of ICS in patients with COPD has been associated the development pneumonia although its role chronic bronchial infection (CBI) is unknown.Patients and severe obstruction have a higher risk Pseudomonas aeruginosa(PsA)and other potentially pathogenic bacteria (PPB),that when repeated,lead to CBI.Objective:to investigate if there an association between recurrent respiratory infections(RRI) frequent exacerbations.Methods: observational retrospective study admitted hospital due...
<b>Background:</b> Fragile COPD (f-COPD) associated with frequent hospital admissions have high morbidity, mortality and use of health resources. These patients should be managed in personalized integrated care models (ICM). <b>Objectives:</b> To evaluate the long-term effectiveness a f-COPD ICM on emergency room (ER) visits, admissions, days hospitalization, improvement status. <b>Methods:</b> Prospective-controlled study analysis cohort assigned to followed-up for maximally 7 years that...