A5059030615- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Public Health and Environmental Issues
- Chronic Disease Management Strategies
- Protease and Inhibitor Mechanisms
- Respiratory and Cough-Related Research
- Delphi Technique in Research
- Nitric Oxide and Endothelin Effects
- Injury Epidemiology and Prevention
- Peptidase Inhibition and Analysis
- Thyroid Disorders and Treatments
- Cardiovascular Issues in Pregnancy
- Obstructive Sleep Apnea Research
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Clinical Research Studies
- Cardiovascular Conditions and Treatments
- Lung Cancer Diagnosis and Treatment
- Heart Failure Treatment and Management
- Nursing Diagnosis and Documentation
- Ion Transport and Channel Regulation
- Long-Term Effects of COVID-19
- Health and Lifestyle Studies
Hospital Italiano La Plata
2008-2022
Hospital San Juan de Dios
2014-2016
University of Nebraska Medical Center
2007
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2001-2004
Universitat de Barcelona
1999-2004
Karolinska Institutet
2001
This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients clinical phenotypes identified by cluster analyses. Data from 2409 COPD of French/Belgian cohorts were analysed using analysis resulting in the identification subgroups, which relevance was determined comparing 3-year all-cause mortality. Classification and regression trees (CARTs) used develop an algorithm these subgroups. tested 3651 Cohorts Collaborative International Assessment...
External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but lacking most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate concurrently compare 3-year all-cause mortality mostly multimorbid patients with COPD.We relied on 24 cohort studies the COPD Cohorts Collaborative International Assessment consortium, corresponding primary, secondary, tertiary Europe, Americas,...
Inhalational challenges with inflammatory mediators may provoke lung function disturbances similar to those shown in spontaneous acute asthma. Cysteinyl leukotrienes (CysLTs) have recently been established as of bronchoconstriction asthma but their effects on pulmonary gas exchange not assessed. We therefore investigated the leukotriene D4 (LTD4) challenge resulting a significant decrease FEV1 (mean ± SE, by 32 3%) 13 nonsmoking, mild asthmatics. Respiratory system resistance (Rrs), and...
Histamine (HIST) produces greater changes in bronchial and pulmonary vasculature, so may produce more gas exchange abnormalities, than methacholine (MTH) after inhalational challenge. The goals of this study were to compare the effects HIST MTH challenge on patients with mild asthma at an equivalent degree bronchoconstriction. Eleven studied (mean±sem age, 22±1 yr; forced expiratory volume one second (FEV 1 ), 91±5% pred) using a randomized, double-blind cross-over design. Respiratory system...
In 2019, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) modified the grading system patients with COPD, creating 16 subgroups (1A–4D). As part of COPD Cohorts Collaborative International Assessment (3CIA) initiative, we aim to compare mortality prediction 2015 and 2019 GOLD staging systems. We studied 17 139 from 3CIA study, selecting those complete data. Patients were classified by ABCD systems, compared predictive ability 5-year both classifications. total, enrolled in...
The objective of this Delphi study was to understand and assess the level consensus among respiratory experts on clinical application GOLD 2023 recommendations in management patients with chronic obstructive pulmonary disease (COPD). comprised two online surveys a participant meeting 34 from 16 countries. Responses 73 questions were recorded using Likert scale ranging 0 (disagreement) 9 (agreement). threshold 75%. Survey 1 survey 2 had 32 participants, respectively; 25 attended meeting....
The CODEX index was developed and validated in patients hospitalized for COPD exacerbation to predict the risk of death readmission within one year after discharge. Our study aimed validate a large external population with variable durations follow-up. Additionally, we recalculate thresholds using cutoffs variables previously suggested 3CIA (mCODEX).Individual data on 2,755 included Cohorts Collaborative International Assessment Plus (3CIA+) were explored. A further two cohorts (ESMI AND...
Furosemide (Fur) may have an anti-inflammatory effect on airways in patients with asthma although its intrinsic mechanism remains elusive. Platelet-activating factor (PAF) is a potent proinflammatory mediator that induces systemic and respiratory effects normal control subjects asthmatics. The aim of this study was to assess whether pretreatment nebulized Fur (40 mg) able modulate PAF-induced asthma. Eleven were studied (mean+/-sem 22+/-0.8 yrs) mild (forced expiratory volume one second,...
<b>Background:</b> Although COPD is an increasing public health problem worldwide, its prevalence in Argentina had never been studied. <b>Objectives:</b> To estimate population and clinical features of a representative sample adults ≥40 years 4 cities Argentina. <b>Methods:</b> Cross-sectional study selected at random through sampling by clusters.We applied structured survey which included: home, assessement, clinical, socio-demographic, risk factors, condition, treatment disease economic...
<b>Background:</b> Different multidimensional grading systems have been used to predict mortality in COPD patients. However, some are with poor calibration or too complex for daily use. As part of the Cohorts Collaborative International Assessment (3CIA) initiative, we aimed develop a risk scoring system management patients clinical practice based on readily available parameters. <b>Methods:</b> A pooled dataset 26 cohorts from 9 countries was used. step-wise selection covariates influencing...
There is partial evidence that COPD expressed differently in women than men, namely on symptoms, pulmonary function, exacerbations, comorbidities or prognosis. a need to improve the characterization of females. We obtained and pooled data 17 139 patients from 22 cohorts analysed clinical differences by sex, establishing relationship between these characteristics prognosis severity disease. Comparisons were established with standard statistics survival analysis, including crude multivariate...