A5021858739- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Medical research and treatments
- Pediatric health and respiratory diseases
- Renal function and acid-base balance
- Gastroesophageal reflux and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neonatal Respiratory Health Research
- Delphi Technique in Research
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Allergic Rhinitis and Sensitization
- Neuroscience of respiration and sleep
- Autoimmune and Inflammatory Disorders Research
- Health, psychology, and well-being
- Voice and Speech Disorders
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- Cystic Fibrosis Research Advances
- Heart Failure Treatment and Management
- Lung Cancer Diagnosis and Treatment
Hospital Universitari i Politècnic La Fe
2011-2024
University Hospital Galway
2023
Holy Cross Hospital
2021-2022
Biogipuzkoa Health Research Institute
2020
Center for Rheumatology
2018
Sociedad Española de Neumología y Cirugía Torácica
2010
Hospital General Universitario De Valencia
2009-2010
Instituto de Ciencias de La Construcción Eduardo Torroja
2010
Universitat de València
1991-2005
Service de la Santé Publique
1997
The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial. To evaluate the prevalence and stability a high level eosinophils (≥300 cells·μL –1 ) its relationship to outcomes, we determined at baseline over 2 years 424 COPD patients (forced expiratory volume 1 s (FEV 60% predicted) 67 smokers without from CHAIN cohort, 308 BODE cohort. We related eosinophil levels exacerbations survival using Cox hazard analysis. In patients, 15.8% cohort 12.3% had...
Pulmonary hypertension in idiopathic pulmonary fibrosis (IPF) is indicative of a poor prognosis. Recent evidence suggests that tetrahydrobiopterin (BH4), the cofactor nitric oxide synthase (NOS), involved and artery endothelial-to-mesenchymal transition (EnMT) may contribute to fibrosis. However, role BH4 remodelling secondary unknown. This study examined system plasma arteries from patients with IPF as well antiremodelling antifibrotic effects precursor sepiapterin rat bleomycin-induced...
Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation (ECOPD) that impact negatively the course their disease. ECOPD are heterogeneous events unclear pathobiology and non-specific diagnosis. Network analysis is a novel research approach can help unravelling complex biological systems. We hypothesised comparison multi-level ( i.e. , clinical, physiological, biological, imaging microbiological) correlation networks determined during convalescence...
To explore the effect of long-term therapy with azithromycin in regards to airway oxidative stress markers exhaled breath condensate (EBC) adult patients stable non-cystic fibrosis (CF) bronchiectasis.Open-label prospective study 30 randomized 250 mg three times per week during 3 months (16 patients) or control (14 patients). Primary outcome were changes nitric oxide, 8-isoprostane, pH, nitrites and nitrates EBC. Secondary outcomes exacerbation rates, dyspnoea (Borg scale), sputum volume...
Abstract Purpose Chronic cough (cough that persists for ≥ 8 weeks) can cause a range of physical symptoms and psychosocial effects significantly impair patients’ quality life. Refractory chronic (RCC) unexplained (UCC) are challenging to diagnose manage, with substantial economic implications healthcare systems. Methods This retrospective multicenter non-interventional study aimed characterize the profile health resource consumption patients RCC or UCC who attended outpatient clinics at...
Background: Mechanisms underlying cough and bronchoconstriction in patients with cough‐variant asthma (CVA) are not well established. Differences location or degree of activation eosinophils allergic cytokines have been suggested as the likely causes. To address this issue, we carried out a comparative study airway inflammatory markers between CVA classic (CA). The relationship these hyperresponsiveness (AHR) sensitivity has also studied. Methods: Twenty‐seven non‐smokers steroid‐naive (12)...
Inhaled corticosteroid (ICS) with long-acting beta-2 agonists is a well-documented combination therapy for chronic obstructive pulmonary disease (COPD) based on its additive anti-inflammatory properties. By contrast, the recommendation of ICS in muscarinic antagonist (LAMA) not evidence-based. In this study, neutrophils obtained from COPD patients were used to compare effects aclidinium bromide (a antagonist) corticosteroids and their potential effect. Human sputum blood isolated healthy...
This study has a twofold objective: 1) to explore what extent suffering from asthma affects the HRQL of men and women differently at several stages disease severity 2) analyze whether informed poorer asthmatic is related their higher scores on instruments measuring emotionally disordered symptoms. One hundred fifty‐one outpatient asthmatics (84 67 men) completed Spanish versions Asthma Quality Life questionnaire (AQL), as well anxiety depression inventories. A full history, physical...
Dyspnea is a main feature of symptomatology in asthma, and its perception does not necessarily correlates well with airway obstruction. The aim this study was twofold: Citation to identify factors determining the subjective degree dyspnea patients different grades stable bronchial asthma compare various clinical methods existing for grading dyspnea. investigation comprised 153 outpatients asthma. parameters studied were following: demographic characteristic subjects, baseline score by means...
Abstract Background The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor control deterioration airflow. Recent data indicate that Mucin 1 ( MUC 1) membrane mucin can mediate chronic rhinosinusitis, but the role uncontrolled unknown. objective was analyze previously unexplored on asthma. Methods expression evaluated by real‐time PCR human bronchial epithelial cells HBEC ) blood neutrophils from (n = 27), controlled mild 16), healthy...
Non-T2 severe asthma and chronic obstructive pulmonary disease (COPD) are airway inflammatory disorders with a poor response to corticosteroids. LAS194046, novel pan-Janus kinase (JAK) inhibitor, shows inhibitory effects on T2 allergic lung inflammation in rats. In this work we analyze the of fluticasone propionate their combination neutrophils from non-T2 COPD patients vitro. Neutrophils 23 healthy subjects, 21 were incubated LAS194046 (0.01 nM-1 µM), (0.1 µM) or stimulated...
Abstract Background Several clinical studies have shown that smoking in asthmatics and chronic obstructive pulmonary disease patients is closely associated with corticosteroid refractoriness. In this work, we analyzed glucocorticoid insensitivity human artery endothelial cells ( HPAEC s) under cigarette smoke extract CSE ) exposure as well the possible additive effects of combination therapy a phosphodiesterase PDE )‐4 inhibitor. Methods Interleukin IL )‐8 was measured cell supernatants by...