A5058126569- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Phosphodiesterase function and regulation
- Glycosylation and Glycoproteins Research
- Infectious Diseases and Mycology
- Neuroscience of respiration and sleep
- Medical Imaging and Pathology Studies
- Genetic and Kidney Cyst Diseases
- Chemotherapy-related skin toxicity
- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Respiratory and Cough-Related Research
- Sinusitis and nasal conditions
- Gastric Cancer Management and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
Hospital General Universitario De Valencia
2015-2024
Universitat de València
2014-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2024
Centre for Biomedical Network Research on Rare Diseases
2013-2024
Centro de Investigación Biomédica en Red
2016-2024
Instituto de Salud Carlos III
2012-2023
Medical Research Network
2023
Hospital Clínico Universitario de Valencia
2011-2022
Ministerio de Ciencia, Innovación y Universidades
2021
Universitat Jaume I
2016-2021
<h3>Background</h3> Cigarette smoking contributes to lung remodelling in chronic obstructive pulmonary disease (COPD). As part of remodelling, peribronchiolar fibrosis is observed the small airways patients with COPD and airway obstruction. Epithelial mesenchymal transition (EMT) appears be involved formation fibrosis. This study examines EMT process human bronchial epithelial cells (HBECs) from non-smokers, smokers as well vitro effect cigarette smoke extract (CSE) on EMT. <h3>Methods</h3>...
Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer activator of transcription 3 (STAT3) protein activated in lung fibroblasts alveolar type II cells (ATII), thereby contributing to IPF. Although activation Janus kinase 2 (JAK2) has been implicated proliferative disorders, its role IPF unknown. aim this study was analyze JAK2 IPF, determine whether JAK2/STAT3 inhibition a potential therapeutic...
<h3>Background</h3> Idiopathic pulmonary fibrosis (IPF) is characterised by the aberrant epithelial to mesenchymal transition (EMT) and myofibroblast accumulation. Sphingosine-1-phosphate (S1P) sphingosine kinase 1 (SPHK1) have been implicated in lung transition, but their role EMT expression patients with IPF unknown. <h3>Methods results</h3> S1P levels were measured serum (n=27) bronchoalveolar lavage (BAL; n=15) from controls (n=30 for n=15 BAL studies). SPHK1 was tissue (n=12) (n=15)....
Mucociliary malfunction occurs in chronic obstructive pulmonary disease (COPD) and compromised functions of ciliated bronchial epithelial cells may contribute to this. Cigarette smoke, a major risk factor for COPD, impairs ciliary beat frequency (CBF). cAMP augments CBF. This vitro study addressed, differentiated, primary human cells, whether roflumilast N-oxide, PDE4 inhibitor, (i) CBF; (ii) prevents the reduction CBF induced by cigarette smoke extract (CSE); (iii) protects against loss...
Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends poor prognosis. Recent studies using vasodilators approved for PH have failed improving IPF mainly due to ventilation ( V )/perfusion Q ) mismatching oxygen desaturation. Janus kinase type 2 (JAK2) non-receptor tyrosine activated by broad spectrum of profibrotic vasoactive mediators, but its role associated unknown. Objective The study JAK2 as potential target treat...
Mucus hypersecretion and mucin MUC5AC overexpression are pathological features of chronic obstructive pulmonary disease (COPD). This study examines the inhibitory effect aclidinium, a new long-acting muscarinic antagonist, on expression in human airway epithelial cells. mRNA (RT-PCR) protein (ELISA immunohistochemistry) were studied bronchial tissue differentiated cells activated with carbachol (100 μM) or cigarette smoke extract absence presence aclidinium. Carbachol increased bronchus...
<h3>Background</h3> Fibroblast to myofibroblast transition is believed contribute airway remodelling in lung diseases such as asthma and chronic obstructive pulmonary disease. This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast transition. <h3>Methods</h3> Human bronchial fibroblasts were stimulated with carbachol (10<sup>−8</sup> 10<sup>−5</sup> M) or transforming growth factor-β1 (TGF-β1; 2 ng/ml) presence absence aclidinium...
Liposomes have been intensively investigated as carriers for different applications in dermatology and cosmetics. Ascorbic acid has potent antioxidant anti-inflammatory properties preventing photodamage of keratinocytes; however, due to its instability low skin penetration, an appropriate carrier is mandatory obtain desirable efficacy. The present work investigates the ability a specific ascorbate phosphatidylcholine (PC) liposome overcome barrier stratum corneum deliver active agent into...
Different demographic, clinical and laboratory variables have been related to the severity mortality following SARS-CoV-2 infection. Most studies applied traditional statistical methods in some cases combined with a machine learning (ML) method. This is first study date comparatively analyze five ML select one that most closely predicts patients admitted COVID-19. The aim of this single-center observational classify, based on different types variables, adult COVID-19 at increased risk...
Summary Background Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response glucocorticoids through down‐regulation of histone deacetylase (HDAC) activity. Objective To study effects phosphodiesterase (PDE)‐3 4 inhibitors their combination vs. a model lipopolysaccharide (LPS)‐induced cytokine release alveolar macrophages under oxidative conditions. Methods Differentiated U937 human were stimulated with H...
Pulmonary hypertension in idiopathic pulmonary fibrosis (IPF) is indicative of a poor prognosis. Recent evidence suggests that tetrahydrobiopterin (BH4), the cofactor nitric oxide synthase (NOS), involved and artery endothelial-to-mesenchymal transition (EnMT) may contribute to fibrosis. However, role BH4 remodelling secondary unknown. This study examined system plasma arteries from patients with IPF as well antiremodelling antifibrotic effects precursor sepiapterin rat bleomycin-induced...
Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on vessels is unknown. Here we analyzed the contribution of PH patients with IPF and potential mechanism implicated. arteries, lung tissue serum control subjects (n = 20), 20) were used study expression localization IL-11Rα. Two models bleomycin-induced Tie2-GFP transgenic mice evaluate endothelial cells artery remodeling. The...
Primary ciliary dyskinesia (PCD) is a clinically uniform entity, although cilia motility and structure can vary among patients, making diagnosis difficult. Chronic sinusitis, bronchiectasis, sinus hypoplasia, secretory otitis media, low fertility are common in PCD patients. The aim of this work was to correlate nasal activity with clinical structural abnormalities PCD. A secondary evaluate the usefulness high-resolution digital high-speed video (DHSV) PCD.We analyzed mucociliary transport...