A5040234663- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Adenosine and Purinergic Signaling
- Dialysis and Renal Disease Management
- Genetic factors in colorectal cancer
- Prenatal Screening and Diagnostics
- Immunotherapy and Immune Responses
- Sepsis Diagnosis and Treatment
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- Immune Response and Inflammation
- Renal and related cancers
- Estrogen and related hormone effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Erythropoietin and Anemia Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- IL-33, ST2, and ILC Pathways
- Traumatic Brain Injury Research
- Neutropenia and Cancer Infections
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
Ben-Gurion University of the Negev
2015-2025
Soroka Medical Center
2013-2025
Assuta Medical Center
2022
University of Michigan
2014
Pediatric Nephrology of Alabama
2005
Bar-Ilan University
2003
Fresenius Medical Care (Germany)
2003
The Royal Free Hospital
2001
University College London
2001
Royal Free London NHS Foundation Trust
2001
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement...
Abstract Objective: Obese patients demonstrate a variety of biochemical, metabolic, and pulmonary abnormalities. Inflammatory mediators such as tumor necrosis factor‐α interleukin‐6 (IL‐6) may have direct effect on glucose lipid metabolism. Hypoxemia in itself induces release IL‐6. The aim this study was to examine the relationship between IL‐6 levels healthy volunteers (control group) three different groups obese patients: without obstructive sleep apnea syndrome (OSAS), with OSAS, obesity...
Background. In a previous study we demonstrated the inhibitory effect of 1,25-dihydroxyvitamin D (1,25(OH)2D3) and its less calcaemic analog 1,24(OH)2D2 on production tumour necrosis factor alpha (TNFα) by human peritoneal macrophages. The aim present is to examine whether this vitamin inhibition TNFα mediated major transcription factor, nuclear factor-κB (NFκB).
Background Circulating cell-free DNA (CFD) levels may be elevated in trauma, stroke, sepsis, pre-eclampsia and cancer. Owing to the complex expensive methodology, detection of CFD has hitherto been confined research laboratories. This study presents a simple, inexpensive accurate test for CFD. Methods Using commercial fluorescent SYBR ® Gold stain, biological fluids were directly assayed without prior extraction amplification. Stain was added sample 96-well plates (final stain dilution:...
Aim The aim of the current study is to assess mortality prediction accuracy circulating cell-free DNA (CFD) level at admission measured by a new simplified method. Materials and Methods CFD levels were direct fluorescence assay in severe sepsis patients on intensive care unit (ICU) admission. In-hospital and/or twenty eight day all-cause was primary outcome. Results Out 108 with median APACHE II 20, 32.4% have died hospital/or 28-day. higher decedents: 3469.0 vs. 1659 ng/ml, p<0.001. In...
Elevated circulating cell-free DNA (CFD) levels were found in patients with cancer. The standard CFD assays are work-intensive and expensive. aim was to evaluate cancer a new simple assay. In mice inoculated cells, correlated tumor size. Compared healthy subjects, 38 colorectal (CRC) had higher preoperative (798 ± 409 vs 308 256 ng/mL; P < .0001). free of disease at 1 year, elevated who remained or died (DD). DD (P = .033), combined index carcinoembryonic antigen × exhibited better...
High levels of circulating cell free DNA (CFD) have been associated with poor prognosis in various diseases. Data pertaining to CFD acute myocardial infarction (MI) are scarce. The available data obtained by either electrophoresis or polymerase chain reaction. We evaluated a novel method for the detection patients ST elevation (STEMI) and examined its correlation established markers necrosis ventricular function.Serum concentrations CFD, troponin-T creatine kinase (CK) were measured...
Abstract Objectives: To evaluate circulating cell-free DNA (CFD) measured by a simple fluorescent assay as biomarker of breast cancer. Methods: We enrolled 38 patients with cancer before surgery, two noncancerous lesions, nine after 16 healthy participants, and 29 control women admitted to the hospital emergency ward released without hospitalization. CFD levels were direct fluorescence assay. Results: Presurgery had elevated (1,010 ± 642 ng/mL), which higher than those in group (395 248...
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated these conditions. A single-centre combined cross-sectional longitudinal was conducted 59 to assess levels neuralgia. Cell-free extracted from blood samples of neuralgia compared healthy controls. The findings demonstrated elevated zoster, which remained for 3 months longer following treat-ment. These...
Background Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and mortality the production tumor necrosis factor alpha interleukin 6 in septic animals. Similarly, adenosine was The aim this study determine whether mediates antiinflammatory effects ketamine. Methods Sepsis induced mice by lipopolysaccharide or Escherichia coli inoculation. Leukocyte recruitment cytokine were used as inflammation markers....
Abstract Interleukin‐I (IL‐I) is a major immunoregulatory/proinflammatory cytokine which also affects fibroblast proliferation and function therefore it was of interest to investigate whether its constitutive expression influences the in vivo tumorigenic potential transformed fibroblastoid cell lines. Here we report on strong correlation between IL‐1α reduced tumorigenicity, using various series oncogene‐transformed NIH/3T3‐derived lines produce spontaneously or upon gene transfer, following...
BackgroundAdenosine levels rise during inflammation and modulate inflammatory responses by engaging with four different G protein-coupled receptors. It is suggested that adenosine exhibits pro-inflammatory effects through its A1 receptor (A1R), anti-inflammatory A2A (A2AR). Therefore, understanding of the mechanisms govern regulation may advance treatment various disorders. We previously reported peak A1R expression leukocyte recruitment, followed a in A2AR resolution.Principal FindingsHere,...
Commercial peritoneal dialysis solution (CDS) is known to have a detrimental effect on the capacity of macrophages (PM phi) kill bacteria and produce acute phase cytokines. This cytotoxic largely caused by low pH CDS. Because cytoplasmic (pHi) an important determinant cellular function, CDS pHi PM phi from continuous ambulatory patients was studied. The measured fluorometrically in N-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES)-buffered salt (HBSS) or at values 5.3, 6.5, 7.0, that...
BackgroundCirculating cell-free DNA (CFD) appears following cell damage and release, increases in hemodialysis (HD) patients particularly HD. We hypothesized that CFD is an integrative marker of tissue can be independent predictor for all-cause mortality HD patients.
Preeclampsia and fetal growth restriction are obstetrical syndromes associated with abnormal placental implantation changes in the activation status of maternal leukocytes. This study is aimed to determine by a simple, rapid fluorescent assay serum total cell-free DNA (t-cfDNA) concentrations women preeclampsia those (FGR).A cross-sectional was conducted measuring t-cfDNA concentrations. Women were classified into following groups: 1) patients (n = 21); 2) FGR-estimated weight below...
To study the effect of dialysis fluid on release interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF alpha) by peritoneal macrophages (PM) peripheral blood mononuclear cells (MNC), time course factors involved in this effect.PM MNC were incubated for various periods with Dianeal itself, or varying pH composition. IL-1 was measured radioimmunoassay TNF alpha cytotoxicity assay.PM obtained centrifugation effluent from 3 continuous ambulatory (CAPD) patients. healthy...