A5026179852- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Drug-Induced Hepatotoxicity and Protection
- Ovarian function and disorders
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Neuropeptides and Animal Physiology
- Genetic Associations and Epidemiology
- Effects and risks of endocrine disrupting chemicals
- Neurological Disease Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Aluminum toxicity and tolerance in plants and animals
- Cerebrospinal fluid and hydrocephalus
- Heavy Metal Exposure and Toxicity
- Dietary Effects on Health
- Pediatric Urology and Nephrology Studies
- Spinal Dysraphism and Malformations
- Oral Health Pathology and Treatment
- Natural Compound Pharmacology Studies
- Hedgehog Signaling Pathway Studies
- Liver physiology and pathology
- Sperm and Testicular Function
- Medicinal Plants and Neuroprotection
Koç University
2020-2024
Near East University
2018-2023
Bolu Abant İzzet Baysal University
2018-2021
Düzce Üniversitesi
2016
Summary The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature pain. Salmon calcitonin ( SC ) exhibits antinociceptive effects in treatment various pain conditions. In this study, we explored mechanisms underlying analgesic effect salmon on migrane using glyceryltrinitrate GTN )‐induced model and ex vivo meningeal preparations rats. Rats were intraperitoneally administered saline, (10 mg/kg), vehicle, saline + , (50 μg/kg) alone. Also, applied...
Soluble ACE2 (sACE2) decoys are promising agents to inhibit SARS-CoV-2, as their efficiency is unlikely be affected by escape mutations. However, success limited relatively poor potency. To address this challenge, multimeric sACE2 consisting of SunTag or MoonTag systems developed. These extremely effective in neutralizing SARS-CoV-2 pseudoviral and clinical isolates, perform better than the dimeric trimeric sACE2, exhibit greater 100-fold neutralization efficiency, compared monomeric sACE2....
The aim of this study was to investigate the anti-inflammatory and antioxidant effects Coriandrum sativum extract on liver ischaemia reperfusion injury at light microscopic biochemical levels.
Aim: The aim of this study was to evaluate the effect Hypericum perforatum (HP) oil on wound-healing process in rabbit palatal mucosa. Materials and Methods: Thirty-six New Zealand albino rabbits were randomly allocated following groups; (1) HP (test, n = 18) (2) olive (control, 18). Palatinal excisional wounds created oils topically applied (0.1 ml, 30 s, twice a day). Gingival biopsies excised, analyzed for re-epithelialization (RE) granulation tissue maturation (GTM) days 3, 7, 14 after...
Rhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin.Depending on the dose, poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction.The purpose of this study is to investigate RH Black Sea Region liver.Male mice were divided into five groups twelve each, two being control (distilled water) others (RH) (25, 50, 75 mg/kg) 0.01 mg/kg grayanotoxin (GTx) groups.Liver tissues collected 24...
The aim of this study is to investigate the effects Protocatechuic acid and Corchorus olitorius on streptozotocin (STZ) induced diabetic rat testis tissue. Randomly selected Wistar Albino rats were divided into five groups as; Diabetes Mellitus, Mellitus treated with Olitorus (STZ+CO), Protacatechuic (STZ+PCA), (CO), (PCA) Control. Diabetic model was generated by intraperitoneal injection 60 mg/kg Streptozotosin. After 48 hours STZ injection, blood samples collected from tail vein in order...
Abstract Study question Does UDP-glucuronic acid decarboxylase 1 (UXS1) expression in endometrial stroma cells have a direct effect on the early stages of implantation? Summary answer Decreased UXS1 was found to alter adhesion, invasion, development and function related genes implantation 3D cultures time dependent manner. What is known already The process governed by complex interaction molecular pathways. Some those are well-defined, however, as fertility problems increase with escalating...
Liver ischemia/reperfusion (IR) often affects distant organs, such as small intestine, kidney, and lung. Coriandrum sativum (CS) has an antioxidant anti-inflammatory effect on liver damage. The aim of this study was to investigate the antiapoptotic effects CS extract lung, kidney after IR injury. Small tissues were evaluated scored in terms cell degeneration, inflammation, congestion, well caspase-3 (Cas-3) cluster differentiation 31 (CD31) immunostainings carried out. Renal enzymes,...
BACKGROUND/AIMS: Cadmium element, a heavy metal, has toxic effects on the reproductive system.The current study investigates possible therapeutic of Corchorus olitorius (CO) and Protocatechuic acid (PCA) damage caused by cadmium chloride rat testicular tissue. MATERIALS AND METHODS:Control, CO, PCA, chloride, + PCA CO was formed groups.CO administered orally 250 mg/kg 20 respectively.Cadmium dose 3.5 intraperitoneally.At end three-week experiment period, body weight rats measured then...
To evaluate the clinical stenosis or precursor histological changes that ureteral access sheaths commonly used in ureteroscopic surgeries may cause long term ureter.In this study, animals were divided into 9 groups and according to their groups, ureters of rabbits endoscopically fitted with 2F 3F ureter catheters. The catheters left place withdrawn after a specified period time. All excised evaluated macroscopically, microscopically histologically. Ureter diameters measured FGF-2 (+) labeled...
Following an injury or resection, the mammalian liver has capacity to regain its former volume and functioning by restoring itself. Studies have demonstrated that antioxidants play a role in hepatic regeneration. This study investigated effect of 4-(3,4-dihydroxybenzoyloxymethyl) phenyl-O-β-D-glucopyranoside (PG) obtained from Origanum micranthum on Sixty Wistar Albino rats were used. In sham-operated group, midline abdominal laparotomy was performed without hepatectomy. partial hepatectomy...
Abstract Soluble ACE2 (sACE2) decoy receptors are promising agents to inhibit SARS-CoV-2, as their efficiency is less likely be affected by common escape mutations in viral proteins. However, success may limited relatively poor potency. To address this challenge, we developed a large library of sACE2 fusion proteins, generated with several protease inhibitors or multimerization tags. Among these decoys, multimeric consisting SunTag MoonTag systems, which were originally utilized for signal...
Anti-Müllerian hormone (AMH) and Inhibin B (INHB) in the glycoprotein structure are members of transforming growth factor β family expressed by granulosa cells from puberty. AMH is a that increases life span small developing follicles. For this reason, it widely used to determine ovarian reserve age. Inhibin-B secreted plays role regulation Follicle Stimulating Factor (FSH) determination follicle diameter. There few studies on effect these two age-related hormones histology rats. In study,...
Abstract Study question What are the molecular and physiological effects on human granulosa cells, when CRISPR/dCas9 epigenome edition technology is efficiently used to increase FSH receptor (FSHR) activity? Summary answer The significant in expression of FSHR maintained by dCAS9 systems has several fundamental cellular events involving steroidogenic, life-sustaining,cell death related signaling sub-pathways. known already Manipulation can result biological that include activities as...
Abstract Study question Is it possible to increase the decreased levels of sperm-oocyte binding protein, Juno, restore fertilization capacity oocyte, via use CRISPR/dCas9 activation system? Summary answer JUNO domain (in oocyte) suppressed with melamine was opened using system and capability have been restored. What is known already Melamine a chemical that widely used in manufacture laminates, plastics, etc. Evidence reveals long-term exposure could damage reproductive systems mammals...