A5070681925- Migraine and Headache Studies
- Neurosurgical Procedures and Complications
- Cannabis and Cannabinoid Research
- Neurofibromatosis and Schwannoma Cases
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Trigeminal Neuralgia and Treatments
- Nicotinic Acetylcholine Receptors Study
- Mast cells and histamine
- Pain Mechanisms and Treatments
- Nigella sativa pharmacological applications
- Ion Channels and Receptors
- Saffron Plant Research Studies
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Bioactive Compounds and Antitumor Agents
- Gastrointestinal Tumor Research and Treatment
- Circadian rhythm and melatonin
- Sarcoma Diagnosis and Treatment
- Biochemical effects in animals
- Traumatic Brain Injury and Neurovascular Disturbances
- Sympathectomy and Hyperhidrosis Treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
Bolu Abant İzzet Baysal University
2016-2024
Summary The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature pain. Salmon calcitonin ( SC ) exhibits antinociceptive effects in treatment various pain conditions. In this study, we explored mechanisms underlying analgesic effect salmon on migrane using glyceryltrinitrate GTN )‐induced model and ex vivo meningeal preparations rats. Rats were intraperitoneally administered saline, (10 mg/kg), vehicle, saline + , (50 μg/kg) alone. Also, applied...
Calcitonin gene-related peptide (CGRP), substance P and dural mast cells are main contributors in neurogenic inflammation underlying migraine pathophysiology. Modulation of endocannabinoid system attenuates pain, but its mechanisms action remain unclear. We investigated receptor mediating anti-neuroinflammatory effects modulation vivo model ex hemiskull preparations rats. To induce acute migraine, a single dose nitroglycerin was intraperitoneally administered to male Moreover, isolated rat...
Background Calcitonin gene-related peptide release in trigeminovascular system is a pivotal component of neurogenic inflammation underlying migraine pathophysiology. Transient receptor potential channels and voltage-gated KCNQ/Kv7 potassium expressed throughout are important targets for modulation calcitonin release. We investigated the effects certain transient (TRP) vanilloid 1 4 (TRPV1 TRPV4), ankyrin (TRPA1), metastatin type 8 (TRPM8), channel (Kv7) opener retigabine on from peripheral...
In this study, we aimed to investigate the effects of Nigella sativa seeds and certain species fungi extracts on number degranulation states dural mast cells in rats. Rats were fed ad libitum with normal tap water or extract N. seed, Ramaria condensata , Lactarius salmonicolor piperatus Tricholoma terreum for 3 days. Mast dura mater counted evaluated terms granulation states. Compound 48/80, a cell degranulating agent, T. significantly increased percent degranulated mater, respectively ( p...
<title>Abstract</title> Introduction Giant extradural thoracic schwannomas are very rare tumors in the pediatric age group and often occur together with neurofibromatosis. span across more than 2 vertebral segments have an extraspinal extension of over 2.5 cm. In this case, we report on a 5-year-old boy purely giant schwannoma without accompanying Clinical Presentation 5 year-old male patient; applied to orthopedics traumatology outpatient clinic complaints difficulty walking following waist...
Objective: Inflammation underlies the pathological basis of most diseases.Substance-P is a key mediator that participates in various inflammatory processes and painful conditions.Mast cells (MCs) have role via mediators released from their granules.The experimental models for investigation pathogenesis treatment diseases represent merely certain characteristics cases, therefore, more comprehensive are required.We aimed to compare effects administrations compound-48/80 mast cell suspension...
Objective: The cranial dura mater contains plenty of mast cells and is principally supplied by the middle meningeal artery which has a key role in generation headaches. Neurogenic inflammation caused perivascular nerve activation dural vasodilation held responsible for migraine pain. Dural contribute neurogenic via vasoactive proinflammatory mediators their secretory granules. In present study, it was aimed to investigate effect cell degranulating agent compound 48/80 induced degranulation...
Amaç : İdiyopatik normal basınçlı hidrosefali (iNPH) tanısı ile orta ventriküloperitoneal (VP) ve lumboperitoneal (LP) şant uygulanan hastaların 3 yıllık takip sırasında klinik sonuçları tedavisinde karşılaştığımız problemleri sunmayı amaçladık. Gereç Yöntemler: Çalışmaya 2013 – 2017 tarihleri arasında Nöroloji Nöroşirurji Anabilim Dallarına başvuran, radyolojik olarak iNPH değerlendirilen hastalar retrospektif tarandı.VP LP hastalarda başarı oranları komplikasyonları kayıt edildi. Bulgular:...