Mehmet Çiftçi

ORCID: 0000-0003-4971-4242
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About
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Research Areas
  • Neonatal Health and Biochemistry
  • Dental Radiography and Imaging
  • Animal Nutrition and Physiology
  • Glutathione Transferases and Polymorphisms
  • Enzyme function and inhibition
  • Cholinesterase and Neurodegenerative Diseases
  • Bee Products Chemical Analysis
  • Meat and Animal Product Quality
  • Erythrocyte Function and Pathophysiology
  • Biomedical Research and Pathophysiology
  • Sperm and Testicular Function
  • Genomics, phytochemicals, and oxidative stress
  • Pancreatic function and diabetes
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Metabolism and Genetic Disorders
  • Insect and Pesticide Research
  • dental development and anomalies
  • Pharmacogenetics and Drug Metabolism
  • Orthodontics and Dentofacial Orthopedics
  • Effects of Environmental Stressors on Livestock
  • Dental Health and Care Utilization
  • Antioxidant Activity and Oxidative Stress
  • Chemotherapy-induced organ toxicity mitigation
  • Redox biology and oxidative stress

Bingöl University
2015-2024

University of Garmian
2020

Kurdistan Regional Government
2020

Sivas Cumhuriyet Üniversitesi
2019

Iğdır Üniversitesi
2018

Institute of Science and Technology
2018

Fırat University
2012-2017

Antalya IVF
2017

Akdeniz University
2015-2016

Atatürk University
2001-2013

The aim of the present study was to investigate potential hypocholesterolaemic antioxidant activities cinnamon oil and antibiotic, their effects on fatty acid compositions serum meat in broilers. A total 240 Ross-308 chicks, five days old, were divided randomly into four treatment groups composed 60 chicks each. Experimental were: corn-soybean meal basal diet (Control), supplemented with 10 ppm avilamycin (antibiotic) 500 or 1000 (C500, C1000). Cinnamon lowered cholesterol levels (P <...

10.2754/avb201079010033 article EN cc-by Acta Veterinaria Brno 2010-01-01

Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play important role cellular signaling. The present article focuses on Cd2+ , Cu2+ Zn2+ Ag+ in vitro inhibition GST. For this purpose, GST was purified from Van Lake fish (Chalcalburnus tarichii Pallas) gills with 110.664 EU mg-1 specific activity 79.6% yield using GSH-agarose affinity chromatographic method. metal ions were tested at various concentrations activity. IC50 values found for...

10.1002/jbt.21967 article EN Journal of Biochemical and Molecular Toxicology 2017-07-31

Abstract The 1,2,4‐triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti‐inflammatory, antitumoural, cytotoxic, antioxidant properties. In this study, a series of triazole compounds (M1‐M10) evaluated for some biological activities. vitro qualifications these on acetylcholinesterase (AChE) human carbonic anhydrase enzyme performed. Also, their antitumoral in colon cancer (HT29) cell line cultures examined. addition,...

10.1002/jbt.22239 article EN Journal of Biochemical and Molecular Toxicology 2018-10-28

Cinnamon and its contents have multifactorial properties such as antioxidant, anti-inflammatory antidiabetic. Male infertility is one of the major health problems in life. The aim this study was to investigate effects long-term cinnamon bark oil (CBO) ingestion on testicular antioxidant values, apoptotic germ cell sperm quality adult rats. Twelve male healthy Wistar rats were divided into two groups, each group containing six While olive given control group, 100 mg kg(-1) CBO administered...

10.1111/and.12000 article EN Andrologia 2012-08-03

Purpose . The objective of this study was to assess gonial angle under the classification by comparing panoramic radiograph and lateral cephalometric radiograph. Materials Methods 49 patients (25 males, 24 females) with an age range 12–29 years participated in present study. Subjects were retrospectively selected among those categorised as skeletal dental Class I, II, III malocclusion group. Using radiograph, mandibular ramal planes drawn based on these planes. Gonial determined from two...

10.1100/2012/219708 article EN cc-by The Scientific World JOURNAL 2012-01-01

This study was conducted to investigate the effect of quercetin on carbon tetrachloride (CCl4)-induced sperm damages, testicular apoptosis and oxidative stress in male rats. Group 1 served as control, group 2 treated with only quercetin, 3 CCl4 4 received + quercetin. All administrations were performed by gavage maintained for 10 weeks. administration caused significant decreases absolute relative reproductive organ weights, motility, concentration glutathione peroxidase (GSH-Px) catalase...

10.1111/and.12159 article EN Andrologia 2013-09-10

The aim of this study was to investigate whether pomegranate juice (PJ) consumption has an ameliorating effect on carbon tetrachloride (CCl 4 )-induced sperm damages and testicular apoptosis associated with the oxidative stress in male rats. comprised four groups (groups 1–4). Group 1 received olive oil + distilled water daily; group 2 treated 5 ml/kg PJ 3 0.25 CCl dissolved oil, weekly daily PJ. All administrations were performed by gavage maintained for 10 weeks. administration caused...

10.1177/0748233713499600 article EN Toxicology and Industrial Health 2013-09-30

Abstract The use of quail meat and eggs has made this animal important in recent years, with its low cost high yields. Glutathione S‐transferases (GST, E.C.2.5.1.18) are an enzyme family, which play a critical role detoxification system. In our study, GST was purified from liver tissue 47.88‐fold purification 12.33% recovery by glutathione agarose affinity chromatography. purity checked SDS‐PAGE method showed single band. addition, inhibition effects (3a R ,4 S ,7 ,7a )‐2‐(4‐(( E...

10.1002/jbt.22034 article EN Journal of Biochemical and Molecular Toxicology 2018-01-19

In this study, it was aimed to investigate the likelihood of detrimental effects carbon tetrachloride (CCl4) on male reproductive system through oxidative stress mechanism and also protective cinnamon bark oil (CBO). For purpose, 28 healthy Wistar rats were divided into four groups, seven in each. Group 1 received only olive daily; group 2 treated with 100 mg kg−1 CBO 3 0.25 ml CCl4 weekly; 4 weekly + daily CBO. All administrations made by intragastric catheter maintained for 10 weeks. Body...

10.1111/and.12072 article EN Andrologia 2013-02-15

Glucose-6-phosphate dehydrogenase (G6PD) plays a key function in various biochemical processes as they produce reducing power of the cell. Thus, metabolic reprogramming nicotinamide adenine dinucleotide homeostasis is reported to be an important step cancer progression well combinational therapeutic approaches. In this study, effects antibiotics, furosemide, cefazolin, cefuroxime, gentamicin and clindamycin on rat erythrocyte G6PD enzyme was studied vitro conditions. The purified by 2',...

10.1080/01480545.2018.1481083 article EN Drug and Chemical Toxicology 2018-06-27

The thioredoxin system, found in all living creatures, consists of protein (Trx), reductase enzyme (TrxR), and NADPH. In this study, turkey liver mitochondrial TrxR with 3.07 EU $\times $ mg$^{-1}$ specific activity was purified 990-fold a yield 2.05{\%} using 2',5'-ADP Sepharose 4B affinity chromatography. purity the measured molecular weight its subunits determined to be 45.5 kDa by SDS-PAGE. mass enzyme's natural state 88 Sephadex-G 150 gel filtration addition, characteristic kinetic...

10.3906/kim-1603-135 article EN TURKISH JOURNAL OF CHEMISTRY 2017-01-01

The effects of gentamicin sulfate on carbonic anhydrase (CA) enzyme activity in vitro human and vivo rat erythrocytes were investigated. For study, anhydrase-I -II (HCA-I HCA-II) purified by affinity-column chromatography, rats used for study. In CA was determined colorimetrically using the CO2-hydration method Wilbur Anderson as modified Rickli et al. Gentamicin (1.98-9.90 mM) showed inhibitory HCA-I HCA-II hydratase up to a 2 mM concentration, when C02-hydratase method. Rat erythrocyte...

10.1248/bpb.25.966 article EN Biological and Pharmaceutical Bulletin 2002-01-01

Abstract Glucose‐6‐phosphate dehydrogenase (G6PD) and 6‐phosphogluconate (6PGD) play an important function in various biochemical processes as they generate reducing power of the cell. Thus, metabolic reprogramming reduced nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis is reported to be a vital step cancer progression well combinational therapeutic approaches. In this study, N‐ benzoylindoles 9a‐ ‐ 9d , which form main framework many natural indole derivatives such...

10.1002/jbt.22193 article EN Journal of Biochemical and Molecular Toxicology 2018-07-10

Royal jelly (RJ) is reflecting the flora around apiaries as a result of foraging activity honeybees and therefore, pollen analysis could be used to verify its botanical/geographical origin. Colon cancer treatment by means chemotherapeutics agents reflects substantial problem for organism due high toxicity other viable cells body. To explore chemopreventive approach enhancing colon efficacy, antioxidant antiproliferative effects RJ in HT-29 were assessed. Cell proliferation was performed...

10.3906/bot-2109-8 article EN TURKISH JOURNAL OF BOTANY 2021-12-28
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