A5019571278- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Heavy Metal Exposure and Toxicity
- Sperm and Testicular Function
- Reproductive Physiology in Livestock
- Nigella sativa pharmacological applications
- Pesticide Exposure and Toxicity
- Curcumin's Biomedical Applications
- Reproductive Biology and Fertility
- Saffron Plant Research Studies
- Arsenic contamination and mitigation
- Polyamine Metabolism and Applications
- Genomics, phytochemicals, and oxidative stress
- Meat and Animal Product Quality
- Cancer Treatment and Pharmacology
- Pharmacological Effects of Natural Compounds
- Selenium in Biological Systems
- Chemotherapy-induced cardiotoxicity and mitigation
- Flavonoids in Medical Research
- Sesame and Sesamin Research
- Silymarin and Mushroom Poisoning
- Vitamin C and Antioxidants Research
- Acute Lymphoblastic Leukemia research
- Cholinesterase and Neurodegenerative Diseases
- Milk Quality and Mastitis in Dairy Cows
Aksaray University
2022-2025
ORCID
2023
Atatürk University
2013-2022
Marienhospital Stuttgart
2018-2022
Başkent University
2014-2017
Fırat University
2009-2011
Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity reduces its clinical utility in humans. The present study aimed to assess the ameliorative effect of curcumin against DXR-induced rats. Rats were subjected oral treatment (100 and 200 mg/kg body weight) 7 days. Cardiotoxicity was induced by single intraperitoneal injection DXR (40 on 5th day rats sacrificed 8th day. Curcumin ameliorated lipid peroxidation, glutathione depletion, decrease antioxidant...
In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), α-glycosidase (α-Gly), butyrylcholine esterase (BChE), acetylcholine (AChE) activities in brain, heart, liver, testis, kidney tissues rats. CA were significantly decreased heart given HSP, SA, SA+HSP-100, SA+HSP-200 compared control (p < 0.05). liver tissue, AChE BChE...
Silymarin (SLY) and naringin (NRG) are natural flavonoids that have been reported to many benefits medicinal properties. The present study was designed investigate the protective effect of SLY NRG against methotrexate (MTX)-induced nephrotoxicity in experimental animals. Rats were subjected oral pretreatment (25 50 mg/kg body weight (b.w.)/day) (50 100 b.w./day) for 7 days renal toxicity induced by single intraperitoneal administration MTX (20 b.w.). resulted an increase serum markers, lipid...
Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) chemotherapeutic drug, which extensively used the treatment of multiple human malignancies. In our study, we aimed to investigate effects CYP CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, butyrylcholinesterase enzyme activities brain, heart, testis, liver, kidney tissues rats....
Gentamicin is commonly used against gram-negative microorganisms. Its therapeutic use mainly limited by nephrotoxicity. This study was aimed at evaluating the effect of rutin on oxidative stress, inflammation, apoptosis, and autophagy in gentamicin-induced nephrotoxicity rats. The rats were treated with saline intraperitoneally (group I), 150 mg/kg orally II), 80 gentamicin for 8 d III), or plus IV). serum urea, creatinine, kidney malondialdehyde (MDA), reduced glutathione (GSH) levels...
Cisplatin (CP) treatment causes damage in the male reproductive system. Rutin (RUT) is a naturally occurring flavonoid glycoside that has antioxidant and anti-inflammatory properties. This study aimed to investigate effects of RUT against cisplatin-induced toxicity rats. Twenty-one adult Sprague Dawley rats were used. The control group received physiological saline with oral gavage during 14 days, was injected intraperitoneally (IP) 10th days study. CP Group 10 mg kg-1 IP day. + (150 )...
Paracetamol (PC) is a safe analgesic and antipyretic drug at therapeutic doses, it widely used in clinics. However, high can induce hepatotoxicity nephrotoxicity. Chrysin (CR) natural flavonoid that has biological activities include being an antioxidant, anti-inflammatory, anti-cancer agent. The main objective of this study was to investigate the efficacy CR against PC-induced nephrotoxicity rats. given orally via feeding needle male Sprague Dawley rats as single daily dose 25 or 50 mg/kg...
Doxorubicin (DXR) is one of the most important chemotherapeutic agent. However, nephrotoxicity reduces its clinical utility in humans. The aim study was to investigate protective effects curcumin (CMN) against DXR-induced nephrotoxicity. Rats were subjected oral treatment CMN (100 and 200 mg/kg body weight) for 7 days. Nephrotoxicity induced by single intra peritoneal injection DXR (40 on fifth day then experiment terminated eighth day. Nephroprotective associated with decrease serum...