The detection and control of pro-inflammatory response is crucial in the early stages viral infection. Coronavirus disease 2019 (COVID-19) an emerging global concern optimal treatment has yet to be determined. Unknown COVID-19 important during patient monitoring. IL-6 one key cytokines after activated macrophages. Therefore, systemic levels SARS-CoV-2 infected patients may a parameter for disease. This review focused on induction infections as target molecule monitoring cellular response.

Context: Almond oil is used in traditional and complementary therapies for its numerous health benefits due to high unsaturated fatty acids content.Objectives: This study investigated the composition vitro anticancer activity of almond from Northern Cyprus compared with Turkey.Materials methods: was obtained by supercritical CO2 extraction analyzed GC-MS. Turkey provided Turkish pharmacies. Different concentrations oils were incubated 24 48 h Colo-320 Colo-741 cells. Cell growth cytotoxicity...

Resveratrol and quercetin are phytochemicals that found in a variety of plants. The aim this study was to investigate the effect resveratrol on epithelial-mesenchymal transition (EMT) CD133+ CD133− pancreatic cancer cells. Cancer stem cells (CD133+ cells) were obtained from PANC-1 by MiniMACS system. treated with different concentrations (5, 10, 25, 50, 100 µM) quercetin. Cell growth cytotoxicity evaluated MTT assay. Anticancer anti-metastatic properties determined immunocytochemistry using...

Background: Quercetin is a flavonol from the flavonoid group of polyphenols, which positively affects human health due to its anti-cancer, anti-inflammatory, anti-microbial and cardioprotective effects. The effects phenolic compounds, including quercetin, on programmed cell death cellular senescence, have been subject research in recent years. Objective: In this study, we aimed investigate quercetin viability, apoptosis senescence primary (Colo-320) metastatic (Colo-741) colon adenocarcinoma...

Abstract Objectives Saponins are secondary metabolites naturally found in plants with diverse pharmacological properties such as anticancer. This research aimed to explore the anti-cancer of Polygalasaponin XLIV (PS-XLIV) a human colorectal carcinoma cell line derived from Polygala vulgaris roots. Methods HCT166 cells were treated different PS-XLIV concentrations and incubated for 24 48 h. We used immunocytochemistry investigate PS-XLIV’s properties, employing antibodies targeting WNT3A,...

The aim of the study was to establish an in vitro Parkinson's disease (PD) model and investigate cell viability, anti-inflammatory, anti-apoptotic neuroprotective effects catechin EGCG SK-N-AS PD cells.SK-N-AS human neuroblastoma cells were used. To develop model, exposed 6-hydroxydopamine. Model control performed after ELISA analysis dopamine α-synuclein levels culture medium. Catechin administered cells. Cell viability measured using MTT assay trypan blue staining. Anti-inflammatory...

Origanum onites L. (O. onites) is one of the cultivated species in Turkey. The aim this study was to determine cytotoxicity and cellular antioxidant effects O. essential oil, carvacrol p-cymene on HCT116 HepG2 cells. oil components were analyzed by GC/MS GC/FID. Cytotoxicity via MTT assay Cellular activities determined with DCFH-DA method. analysis identified (%78.4) as main constituent oil. 400 µg/ml concentration found be active against Also, showed higher activity than p-cymene. We...

Objective: Hesperidin and naringin are flavonoids that found in citrus fruits. Our aim was to create an vitro model of Alzheimer's disease (AD) evaluate the neuroprotective effects hesperidin SK-N-AS AD cells. Methods: Aβ25-35 used The cytotoxicity evaluated using MTT. β-amyloid, tau α-synuclein distributions were analyzed indirect immunoperoxidase staining investigate naringin. Results: created by 1 µM for 48 hours after ThT staining. intensity β-amyloid reduced through both treatment Both...

Boswellia sacra Flueck essential oil is obtained from frankincense trees. The aim of this study was to investigate the in vitro anti-cancer activity (BS) CD133+ and CD133- Colo-320 cells. Essential analyzed by GC-MS. cells, cancer stem were MiniMACS system. Cytotoxicity evaluated with MTT assay. Anti-cancer BS investigated immunocytochemistry. 41 compounds identified oil. 1:2 dilution found be active against all cells for 24 h incubation. β-catenin immunoreactivity significantly decreased...

Methotrexate (MTX) is an effective cytotoxic agent which used to treat malignancies and inflammatory diseases.Origanum onites (O.onites) found throughout the Eastern Mediterranean region has been in traditional medicine.The essential oils (EOs) of O. rich highly bioactive phytochemicals such as carvacrol (CVR) antiviral, antioxidant, anticancer proapoptotic properties.The aim this study was investigate protective effects CVR onites-EO treatment MTX-induced hepatorenal toxic rats' liver...

Breast cancer is the most common among women and in order to create alternative treatments different types of vivo vitro studies have used various plant-based therapeutic agents. Humic acid (HA) induces apoptosis has pharmacological properties including anti-inflammatory anti-proliferative effects. In our study, we examined cytotoxic effects HA at concentrations 5, 10, 20, 50 100 μg/mL human breast adenocarcinoma MCF-7 cell line for 24 48 h. By using MTT method, it been found out that g/mL...

Abstract Obesity is as a global health problem due to its interaction with complex chronic disorders such cardiovascular disorders, type 2 diabetes mellitus (T2DM) and cancer. Despite the fact that pathogenesis of obesity not yet clearly understood, it associated combination psychological, environmental various genetic factors. Here, employing case-control design, we aimed examine effects GHRL c.152C>T (p.Arg51Gln) (rs34911341) c.214G>T (p.Leu72Met) (rs696217) markers on susceptibility...