- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Botany and Plant Ecology Studies
- Pharmacological Effects of Natural Compounds
- Endodontics and Root Canal Treatments
- Genomics, phytochemicals, and oxidative stress
- Traditional Chinese Medicine Analysis
- Phytochemistry and Bioactive Compounds
- Wnt/β-catenin signaling in development and cancer
- Plant Ecology and Soil Science
- Morinda citrifolia extract uses
- Moringa oleifera research and applications
- Marine and environmental studies
- Nuts composition and effects
- Bee Products Chemical Analysis
- Polymer Synthesis and Characterization
- Plant chemical constituents analysis
- Dental Anxiety and Anesthesia Techniques
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical Studies and Bioactivities
- Advances in Cucurbitaceae Research
- Cancer Mechanisms and Therapy
Near East University
2016-2025
University of Cyprus
2021
Mersin Üniversitesi
2017-2020
Context: Almond oil is used in traditional and complementary therapies for its numerous health benefits due to high unsaturated fatty acids content.Objectives: This study investigated the composition vitro anticancer activity of almond from Northern Cyprus compared with Turkey.Materials methods: was obtained by supercritical CO2 extraction analyzed GC-MS. Turkey provided Turkish pharmacies. Different concentrations oils were incubated 24 48 h Colo-320 Colo-741 cells. Cell growth cytotoxicity...
This present study aims to characterize the essential oil compositions of aerial parts M. spicata L. and endemic longifolia ssp. cyprica (Heinr. Braun) Harley by using GC-FID GC/MS analyses simultaneously. In addition, it perform multivariate statistical analysis comparing with existing literature, emphasizing literature published within last two decades, conducted on both species growing Mediterranean Basin. The major components were determined as carvone (67.8%) limonene (10.6%), while...
The genus Eucalyptus L’Hér., is native to Australia with 61 introduced taxa in Cyprus, including E. torquata Luehm., which has a wide distribution on the island. aim of this study was investigate possible seasonal variations chemical composition essential oils juvenile and mature leaves collected from Nicosia, by using multivariate statistical analysis. 12 monthly collections were separately hydrodistilled, GC-FID GC/MS analyses conducted. In general, results revealed 1,8-cineole (mature:...
Abstract Objectives In this study, Rosa damascena Mill. essential oil (RDEO) was aimed to evaluate its potential anti-inflammatory and mitochondria-mediated anti-apoptotic effects in vitro vivo acetic acid (AA)-induced ulcerative colitis (UC) rat model. Methods the UC model, RDEO (100 μL/kg, p.o.) or sulfasalazine mg/kg/p.o.) administered treatment groups. After decapitation, activity index, colon mass macroscopic microscopic damages were determined tissue. TNF-α levels MPO measured effect...
Non-polar and polar compounds were isolated from the leaves chemical composition of essential oil aerial parts Sideritis cypria endemic in Northern Cyprus was also determined.The structures all elucidated by means spectroscopic (UV, NMR: 1D 2D-NMR: 1 H, 13 C, COSY, HSQC, HMBC) methods comparison with literature data.The plant material analysed GC-FID GC-MS, simultaneously.To best our knowledge, secondary metabolites this species determined for first time.As a result, two mixtures four...
Background: Calcium hydroxide is a routinely used material for root canal disinfection during treatment. Natural products have great potential in terms of their antibacterial effects. This study aimed to establish an effective alternative intracanal medicament using Origanum dubium (O. dubium) and Mentha spicata (M. spicata) essential oils. Materials Methods: O. M. spicata, collected from Lefke, Cyprus, were separately subjected hydrodistillation. The obtained oil compositions analysed...
ABSTRACT The genus Eucalyptus belonging to the Myrtaceae family, consists of tall, evergreen trees with leathery leaves. They are indigenous Australia and contain about 900 species subspecies. One important use is production essential oils, which valuable in both medicinal pharmaceutical industries. There 62 naturalized Cyprus including E. camaldulensis torquata. oil constituents leaves these two collected from Northern were isolated by hydro-distillation analyzed GC GC/MS, simultaneously....
In this study, chemical composition and antimicrobial activity of the essential oil Sideritis cypria, which is an endemic taxon in Northern Cyprus, were investigated. The obtained by hydrodistillation analyzed gas chromatography (GC) chromatography-mass spectrometry (GC-MS). general, GC GC-MS analysis illustrated that fifty compounds identified representing 96.9% oil. Major components epi-cubebol (11.9%), trans-piperitol (8.9%) pinene (8.1%), respectively. was tested disc diffusion method...
The genus Teucrium L., belonging to the family Lamiaceae, is divided in ten sections including Polium (Mill.)Schreb.In Cyprus, this section represented by five endemic species: T. micropodioides, cyprium, karpasiticum, kyreniae and salaminium.Essential oils of aerial parts these species were separately obtained hydrodistillation using a Clevenger-type apparatus.Chemical compositions analyzed GC GC/MS, simultaneously.The essential oil yields ranged between 0.03-0.75(v/w).The major components...
Abstract Switchable‐hydrophilicity solvent liquid‐liquid microextraction and dispersive were compared for the extraction of piperine from Piper nigrum L. prior to its analysis by using high‐performance liquid chromatography with UV detection. Under optimum conditions, limits detection quantitation found as 0.2–0.6 0.7–2.0 μg/mg two methods, respectively. Calibration graphs showed good linearity coefficients determination ( R 2 ) higher than 0.9962 percentage relative standard deviations...
Plant derived natural products can provide promising anti-cancer activity and support the development of novel treatment strategies as cytotoxic towards cancer cells was observed in recent studies which different human cell lines were exposed to plant essential oils. In our study, thyme (Thymus capitatus) oil analyzed by GC GC/MS showed high content thymol, p-cymene, carcacrol γ-terpinene representing 62.3%, 10.9%, 6.7% 5.1% total respectively. It tested for its potential therapeutic role...
In this study the volatile oils constituents of inflorescence and unripe fruits Crataegus azarolus L. pallasii Grisb.were investigated.Fifty-four compounds were identified by GC GC-MS analysis.The major outstanding essential oil in all samples (dried fresh C. dried pallasii) were; tricosane (33.8%, 29.3%, 34.0 %), pentacosane (24.6%, 21.1%, 30.8%), heptacosane (12.5%, 10.2%, 11.7%), tetracosane (6.0%, 5.6%, 5.7%), respectively.Besides these alkanes, ten (nonanal, β-elemene, undecanal,...
Wild growing Thymus capitatus (L.) Hoff.m. & Link (Lamiaceae) was collected from three different regions of T.R.N.C. eastern (Yildirim-Tc1), northern (Girne/Bogaz-Tc2) and western (Yedidalga-Tc3) sides. The plant materials were subjected to hydrodistillation method in order obtain essential oils.The composition analysis performed by GC-FID GC-MS systems, simultaneously. results revealed that major components same but the percentages showed variations moderately. Altogether, number compounds...
Helicobacter pylori (H.pylori) is an infective agent and the main resourceful factor of chronic, active type B gastritis, peptic duodenal ulcer, gastric carcinoma mucosa-associated lymphoid tumors.Nowadays, pharmcological treatment H. infections attracts attention besides antibiotic treatment.The aim this study to analyse chemical composition essential oils Thymus capitatus antimicrobial activity against pylori.Aerial parts wild-growing plant materials were collected during flowering stage...
From the aerial parts of Teucrium creticum L. (Lamiaceae) eight compounds, 1 – 8 were isolated using chromatographical methods. Based on results spectroscopical analysis such as UV, 1D-NMR (1H-, 13C-NMR, DEPT-135), 2D-NMR (COSY, HSQC, HMBC, NOESY) and HRMS, structure compounds determined two iridoids, 8-O-acetylharpagide (1) teuhircoside (2), phenylethanoid glycosides, verbascoside (= acteoside) (3) lavandulifolioside (4), four neoclerodane-type diterpenoids, teucrin H3 19-acetylgnaphalin)...
AbstractWild growing Origanum majorana L. var. tenuifolium Weston was collected from three different locations (Om1: Avtepe, Om2: Alevkayası, Om3: Kozanköy) in North Cyprus. The essential oils were hydrodistilled and chemical composition analyses simultaneously performed by GC-FID GC-MS. average yields of 5.46-8.14%. Major compounds flowering Om1 oil cis-sabinene hydrate (45.0%) terpinen-4-ol (11.1%) while those Om3 (Kozanköy) (33.3%), (12.3%) α-terpineol (11.5%). In the post-flowering...
Aim: The study in Northern Cyprus aimed to improve patient-centered care and healthcare practices by examining community perceptions of Herbal Products (HPs) for liver biliary diseases. Materials Methods: self-administered questionnaire utilized this cross-sectional study, which was carried out Nicosia, from October 2021 July 2022, allowed 446 participants provide information on their sociodemographic characteristics attitudes toward HPs. Results: It observed that diseases are common Cyprus,...
Essential oils of the leaves and flowers Phlomis cypria P. brevibracteata were isolated by hydrodistillation analysed GC Gas chromatography - mass spectroscopy (GC-MS), simultaneously. oil yields four samples ranged between 0.07% 0.09% (v/w). The essential (L) (F) found to be rich in β-caryophyllene (L: 21.9%, F: 24.2%) caryophyllene oxide 26.0%, 7.2%). Main constituents determined as 37.4%, 20.8%) germacrene D 47.7%, 17.2%).
BACKGROUND/AIMSEnterecoccus faecalis is the most dominant and isolated resistant species from infected/failed permanent teeth undergoing root canal therapy or painful primary with periapical radiolucency.The main purpose of present research was to compare antimicrobial effectiveness essential oil Origanum onites diode laser irradiation against E. removal canals. MATERIAL METHODSA total 60 retained human incisors were selected randomly divided into six experimental groups as follows: Group 1:...