A5052662762- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Health and Medical Education
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Ethics and bioethics in healthcare
- Health and Medical Research Impacts
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Atrial Fibrillation Management and Outcomes
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Psychology Research and Bibliometrics
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac, Anesthesia and Surgical Outcomes
- scientometrics and bibliometrics research
- Liver Disease and Transplantation
- Acute Ischemic Stroke Management
Pontificia Universidad Católica de Chile
2014-2023
Colegio Médico de Chile
2009-2020
Australian and New Zealand Intensive Care Society
2020
Instituto de Salud Pública de Chile
2020
Hospital Clínico de la Universidad Católica
1994-2014
Centre Hospitalier de Luxembourg
2014
Fundación Chile
2014
Sociedad de Biología de Chile
2013
GTx (United States)
2011
Agaplesion Diakonieklinikum Rotenburg
2001-2008
Abstract Background The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability RRT techniques and antibiotic relate observed trough concentrations to targets. Methods We performed a prospective, observational, multinational, pharmacokinetic study 29 intensive care units from 14 countries. collected demographic, clinical, data. measured meropenem, piperacillin-tazobactam, vancomycin related...
Currently, no vaccine against Pseudomonas is available. IC43 a new, recombinant, protein (OprF/I)-based the opportunistic pathogen, aeruginosa, major cause of serious hospital-acquired infections. has proven immunogenicity and tolerability in healthy volunteers, patients with burns, chronic lung diseases. In order to assess safety who are most at risk acquiring infections, it was evaluated mechanically ventilated ICU patients. We conducted randomized, placebo-controlled, partially blinded...
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as are sufficiently plastic integrate multiple signals, such those from microbes, damaged tissues, ...Read More
To assess the clinical impact of noninvasive mechanical ventilation (NIMV) on stable hypercapnic chronic obstructive pulmonary disease, changes in exercise capacity, dyspnoea and simple physiological parameters were evaluated. The time course these effects during treatment recovery was also assessed. Patients randomly allocated to NIMV (n = 27) or sham-NIMV 15), applied 3 h·day −1 , 5 days a week, for weeks. A 6-min walking distance (6MWD), arterial blood gases, spirometry, pattern...
Deep sedation in critically ill patients is associated with a longer duration of mechanical ventilation and prolonged length stay the intensive care unit. Several protocols have been used to improve these outcomes. We implement evaluate an analgesia-based, goal-directed, nurse-driven protocol treat who receive ventilation.We performed prospective, two-phase (before-after), non-randomized multicenter study that involved 13 units Chile. After observational phase (observational group, n=155),...
Septic shock (SS)-related multiorgan dysfunction has been associated with oxidative damage, but little is known about the temporal damage profile and its relationship to severity. The present work investigated prospectively 21 SS patients. Blood samples were obtained at diagnosis, 24, 72 hours, day 7, 3 months. At admission, thiobarbituric acid reactive substances (TBARSs), plasma protein carbonyls, methionine sulfoxide (MS), ferric/reducing antioxidant power (FRAP), total red blood cell...
Abstract Introduction Previous studies have suggested that high volume hemofiltration (HVHF) may contribute to revert hypotension in severe hyperdynamic septic shock patients. However, arterial pressure stabilization occurs due an increase systemic vascular resistance, which could eventually compromise microcirculatory blood flow and perfusion. The goal of this study was determine if HVHF deteriorates sublingual microcirculation Methods This a prospective, non-randomized at 16-bed,...
Characteristics and factors associated with mortality in patients receiving mechanical ventilation Background: The outcome of mechanically ventilated can be influenced by such as the indication (MV) ventilator parameters.Aim: To describe characteristics MV Chilean critical care units.Material methods: Prospective cohort consecutive adult admitted to 19 intensive units (ICU) from 9 cities who received for more than 12 hours between September 1st, 2003, 28th, 2003.Demographic data, severity...
Invasive candidiasis (IC) epidemiology has changed in critically ill patients and limited data are available Chile.To describe the epidemiological microbiological profile of IC patients.Observational prospective study conducted from October 2001 to August 2003 adults with suspected or confirmed IC.53 met criteria for IC, finding 18 (33.9%) candidemias, 22 (41.5%) disseminated 13 (24.5%) local IC. We identified 8 (44.4%) C. albicans 10 (55.6%) non-albicans Candida candidemias. tropicalis was...
Prevalence of severe sepsis in Intensive Care Units.A national multicentric study Background: Severe (SS) is the leading cause death Units (ICU).Aim: To prevalence SS Chilean ICUs.Material and methods: An observational, cross-sectional using a pre-designed written survey was done all ICUs Chile on April 21st, 2004.General hospital ICU data number hospitalized patients at day, were recorded.Patients followed for 28 days.Results: Ninety four percent participated survey.The occupation index...
Introduction: The use of antibiotics is mandatory in patients during extracorporeal membrane oxygenation (ECMO) support. Clinical studies have shown high variability the antibiotic concentrations, as well sequestration them by ECMO circuit, suggesting that doses and/or interval administration used may not be adequate. Thus, a fast response sensor to estimate concentrations this setting would contribute improve dose adjustments. biosensor PenP has been dynamic range, sensitivity and...