A5060159212- Microbial Inactivation Methods
- Electrodeposition and Electroless Coatings
- Microfluidic and Bio-sensing Technologies
- Electrochemical Analysis and Applications
- Arsenic contamination and mitigation
- Statistical Methods and Bayesian Inference
- Theoretical and Computational Physics
- Statistical Methods and Inference
- Heavy Metal Exposure and Toxicity
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- 3D Printing in Biomedical Research
- Maternal and Neonatal Healthcare
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Birth, Development, and Health
- Infant Development and Preterm Care
- Mathematical Biology Tumor Growth
- Chronic Kidney Disease and Diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Bayesian Methods and Mixture Models
- Computational Fluid Dynamics and Aerodynamics
- Navier-Stokes equation solutions
- Diabetes Management and Research
- Pregnancy and preeclampsia studies
Pontificia Universidad Católica de Chile
2011-2024
University of British Columbia
2024
University of Buenos Aires
2014-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2023
Fundación Ciencias Exactas y Naturales
2013-2023
Research Network (United States)
2020
RELX Group (United States)
2020
Centro Científico Tecnológico - San Juan
2015-2019
Laboratorios Ruiz
2018
Mater Research
2017
Arsenic in drinking water is an established cause of lung cancer, and preliminary evidence suggests that ingested arsenic may also nonmalignant disease. Antofagasta the second largest city Chile had a distinct period very high exposure began 1958 lasted until 1971, when removal plant was installed. This unique scenario provides rare opportunity to investigate long-term mortality impact early-life exposure. In this study, we compared rates 1989–2000 with those rest Chile, focusing on subjects...
Cities in northern Chile had arsenic concentrations of 860 microg/liter drinking water the period 1958-1970. Concentrations have since been reduced to 40 microg/liter. We investigated relation between lung cancer and a case-control study involving patients diagnosed with 1994 1996 frequency-matched hospital controls. The identified 152 cases 419 Participants were interviewed regarding sources, cigarette smoking, other variables. Logistic regression analysis revealed clear trend odds ratios...
Region II of Chile (the second most northerly administrative region) experienced dramatic increases in average arsenic water concentrations beginning 1958, followed by marked declines the 1970s when treatment plants were installed. This history provides a unique opportunity to study time trends development arsenic-related cancers, including lung and bladder cancers. We investigated cancer mortality from 1950 2000 for region compared with V, where drinking was not contaminated arsenic....
Small-scale clinical investigations have demonstrated that single doses of beta-blocking agents can improve left ventricular function in heart failure from idiopathic dilated cardiomyopathy (IDC). The purpose this multicenter trial was to determine the dose-effect characteristics beta-blockade a population includes ischemic (ISCD).Bucindolol is nonselective agent with mild vasodilatory properties. One hundred forty-one subjects class II or III failure, ejection fraction (LVEF) < = 0.40, and...
We tested the hypothesis that women with idiopathic fetal growth restriction (FGR) or preeclampsia (PE) have lower concentrations of some water-retaining hormones, such as aldosterone and estradiol, either preceding concomitant onset reduced plasma volume described in these women. Plasma serum progesterone, were measured serially at monthly intervals 135 pregnant from week 10 until term. Twenty-three developed FGR, 17 had PE, 95 remained normotensive delivered normal-size infants (controls)....
Arsenic in drinking water is known to be a cause of lung, bladder, and skin cancer, some studies report cardiovascular disease effects. The authors investigated mortality from 1950 2000 the arsenic-exposed region II Chile (population: 477,000 2000) comparison with unexposed V. Increased risks were found for acute myocardial infarction (AMI), rate ratios 1.48 men (95% confidence interval (CI): 1.37, 1.59; p < 0.001) 1.26 women CI: 1.14, 1.40; during high-exposure period 1958 1970. highest...
Millions of people worldwide are exposed to arsenic-contaminated water. In the largest city in northern Chile (Antofagasta), more than 250,000 were high arsenic drinking water concentrations from 1958 until 1970 when a treatment plant was installed. Because its unique geology, limited sources, and good historical records, lifetime exposure long-term latency patterns can be assessed this area with better accuracy other arsenic-exposed areas worldwide.We conducted population-based case-control...
Background: Beginning in 1958, the city of Antofagasta northern Chile was exposed to high arsenic concentrations (870 µg/L) when it switched water sources. The exposure abruptly stopped 1970 an arsenic-removal plant commenced operations. A unique scenario like this—with abrupt start, clear end, and large population (125,000 1970), all with essentially same exposure—is rare environmental epidemiology. Evidence increased mortality from lung cancer, bronchiectasis, myocardial infarction, kidney...
Abstract Arsenic in drinking water is an established cause of lung, bladder, and skin cancers adults may also adult kidney liver cancers. Some evidence for these effects originated from region II Chile, which had a period elevated arsenic levels water, particular 1958 to 1970. This unique exposure scenario provides rare opportunity investigate the early-life on childhood mortality; our knowledge, this first study cancer mortality high concentrations water. In article, we compare rates under...
Region II in northern Chile (population 442 570) experienced a sudden major increase arsenic water concentrations 1958 the main city of Antofagasta, followed by reduction exposure when an removal plant was installed 1970. It provides unique opportunity to study latency effects arsenic, and this is first with mortality data up 40 years after reduction. We previously identified high rates year 2000. Here we present rate ratios (RRs) for compared all rest from 2001 2010, unexposed V 1 539 852)...
Abstract Background: Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder of the liver, which may progress to fibrosis or cirrhosis. Recent studies have shown significant impact ethnicity on susceptibility steatosis‐related disease. Aims: To estimate prevalence NAFLD among Chilean Hispanics as well clinical and biochemical variables associated with Methods: Population‐based study Hispanics. The diagnosis was made basis ultrasound evidence absence alcohol consumption hepatitis C...
Abstract This paper discusses the application of a multi‐state model to diabetic retinopathy under assumption that continuous time Markov process determines transition times between disease stages. The consists three transient states represent early stages retinopathy, and one final absorbing state irreversible stage retinopathy. By using with covariables, we explore effects factors influence onset, progression, regression among subjects insulin‐dependent diabetes mellitus. We can also...
Background: Arsenic in drinking water is associated with kidney cancer. Beginning 1958, a region of Chile experienced rapid onset high arsenic exposure water, followed by sharp declines when treatment plants were installed 1971. Methods: For the years 1950–1970, we obtained mortality data from death certificates for an exposed and unexposed Chile. We computerized all 1971–2000. Results: Kidney cancer risks compared started to increase about 10 after exposures began 1958. The peak rate ratio...
The authors organized the Department of Veterans Affairs (VA) Continuous Improvement in Cardiac Surgery Study (CICSS) to provide risk-adjusted outcome data for continuous assessment and improvement quality care all patients undergoing cardiac surgery VA.The use outcomes monitor health has potential advantage over consensus-derived standards being free preconceived biases about how should be provided. Monitoring episodes, as opposed review selected cases (e.g., adverse outcomes), advantages...
Arsenic in drinking water causes increased mortality from several cancers, ischemic heart disease, bronchiectasis, and other diseases. This paper presents the first evidence relating arsenic exposure to pulmonary tuberculosis, by estimating rate ratios for Region II of Chile compared with V years 1958-2000. The authors time patterns exposure, which abruptly 1958 then declined starting 1971. Tuberculosis men started increasing 1968, 10 after high commenced. peak male 5-year ratio occurred...