A5075375521- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Health and Lifestyle Studies
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gallbladder and Bile Duct Disorders
- Nutritional Studies and Diet
- HIV, Drug Use, Sexual Risk
- Pregnancy and preeclampsia studies
- Maternal and Neonatal Healthcare
- Infant Development and Preterm Care
- Lipoproteins and Cardiovascular Health
- Consumer Attitudes and Food Labeling
- Diet and metabolism studies
- School Health and Nursing Education
- Adolescent Sexual and Reproductive Health
- COVID-19 and Mental Health
- Blood Pressure and Hypertension Studies
- Congenital Diaphragmatic Hernia Studies
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Sex work and related issues
- Child Nutrition and Water Access
- Tuberculosis Research and Epidemiology
Pontificia Universidad Católica de Chile
2015-2024
Universidad Latinoamericana
2024
Departamento de Salud
2023
GTx (United States)
2023
Production Development Corporation
2022
Queen's University
2021
Universidad Católica Bolivia San Pablo
2012
Universidad de Antioquia
2011
Viña del Mar University
2011
University of Chile
1998
Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for hospitalized patients with COVID-19. We aimed to evaluate the efficacy and safety of early CP in COVID-19 progression.The study was an open-label, single-center randomized clinical trial performed academic medical center Santiago, Chile, from May 10, 2020, July 18, final follow-up until August 17, 2020. The included within first 7 days symptom onset, presenting risk factors...
Background and rationale for the study. FGF19/15 is a gut-derived hormone presumably governing bile acid (BA) synthesis gallbladder (GB) refilling. FGF19 mRNA present in human GB cholangiocytes (hGBECs); however, physiological significance of GB-derived remains unknown. We investigated whether hGBECs secrete effects cholecystectomy on serum ([FGF19]s) BA synthesis.FGF19 expression was assessed by qRT-PCRs immunostaining terminal ileum, quantified ELISA. Basal (chenodexycholic acid, CDCA)...
Abstract Objective To evaluate the feasibility of diet mediterranisation, in a food-at-work context, and its consequence on metabolic syndrome mid-age unselected healthy male population group. Design One-year longitudinal intervention study. Physical exercise was not modified. Setting All workers Santiago division ‘Maestranza Diesel’, metal-mechanic company servicing mining industry, were invited to participate. Subjects Initially, 145 total 171, average age 39 years, accepted participate...
Osteonecrosis is related to the use of steroids in patients with systemic lupus erythematosus (SLE); its association 'pulses' methylprednisolone (PMP) not clear at present. In a retrospective analysis 190 SLE we found that 19% 36 treated PMP had osteonecrosis compared 6% 154 without treatment (P < 0.04). Risk factors associated were treatment, cushingoid appearance, steroid doses > or = 40 mg/day during first month ratio dose grams/year 12, hematuria and proteinuria. stepwise regression...
In hepatocytes and enterocytes sterol uptake secretion is mediated by Niemann-Pick C1-like 1 (NPC1L1) ATP-binding cassette (ABC)G5/8 proteins, respectively. Whereas serum levels of phytosterols represent surrogate markers for intestinal cholesterol absorption, precursors reflect biosynthesis. Here we compare biliary in ethnically different populations patients with gallstone disease (GSD) stone-free controls to identify differences transport synthesis between these groups. this case-control...
Obesity and metabolic syndrome (MetS) are key risk factors for chronic disease. Dietary patterns critical in the incidence persistence of obesity MetS, yet there is few data linking diet to MetS Chile. Our objective was use a locally validated index evaluate adherence Mediterranean dietary pattern its correlations with overweight/obesity (OW/O) prevalence Chilean adults. We conducted nationwide, cross-sectional online survey adults complete self-reported body mass (n = 24,882). A subsample...
To analyze the nutritional status and plasma levels of vitamins minerals in a cohort Chilean children between 4 14 years old from three cities Chile (Santiago, Antofagasta, Concepcion).This is descriptive analysis micronutrient as it relates to obesity food consumption.This study included 1235 schools Santiago (central area), Antofagasta (northern Concepcion (southern area) Chile.Plasma micronutrients revealed deficiencies all these cities. Copper (26.4%) calcium (33.0%) were found whereas...
Objectives: The gestational weight gain chart published by Rosso and Mardones (RM) was used the Ministry of Health in Argentina from 1990s until 2009, when it replaced Calvo et al. (CEA). This study compared diagnostic capability RM CEA charts for identifying mothers at risk delivering babies with signs intrauterine growth impairment (Birth length<50 cm, Birth <2500 g, <3000 g >4000 g). Methods: Data pregnant women neonates studied Santiago, Chile (n = 27,600), as well a...
Low renin hypertension (LRH), which accounts for 10-20% of patients with idiopathic "essential" hypertension, bears hormonal similarities to mineralocorticoid-induced but elevated mineralocorticoid concentrations have not been found. Some LRH normal, rather than suppressed, plasma aldosterone concentrations, so that the ratio concentration PRA (Aldo/PRA) is high, suggesting inappropriately increased biosynthesis. We characterized CYP11B2 gene encodes synthase, P450c11AS, in hypertensive and...
Abstract Objective To test the hypothesis that maternal food fortification with omega-3 fatty acids and multiple micronutrients increases birth weight gestation duration, as primary outcomes. Design Non-blinded, randomised controlled study. Setting Pregnant women received powdered milk during their health check-ups at 19 antenatal clinics delivered two maternity hospitals in Santiago, Chile. Subject were assigned to receive regular ( n = 477) or a product fortified 495). Results...
ObjectiveTo compare the performance of two tests for diagnosing latent tuberculosis (TB) infection in HIV-positive population Chile, order to better identify subjects who might benefit from TB chemoprophylaxis.DesignThis was a cross-sectional study among individuals attending three HIV outpatient clinics Santiago, tested with 2-TU purified protein derivative, QuantiFERON®-TB Gold 'in-tube' (QFT-G), and chest X-ray.ResultsA total 116 were enrolled study, having mean CD4 count 393 cells/μl...
Objectives Vitamin D (VD) enhances the immune response against Mycobacterium tuberculosis in vitro, and VD deficiency has been described patients with active (TB). However, role of hypovitaminosis pathogenesis early TB infection acquisition is unclear. We aimed to evaluate association deficiency, season year, latent household contacts (HHC), given that this a potentially modifiable condition often related nutritional deficiencies lack sun exposure. Methods prospectively enrolled new...
After enforcement of a new food labeling law in 2016, Chile exhibits greater offer to reduced sugar products with addition non-nutritive sweeteners (NNS). Many these are consumed by children, who at risk reaching the acceptable daily intake (ADI) additives. The objective this study was evaluate levels NNS Chilean schoolchildren after enactment aforementioned law. A total 250 children 6–12 years old were surveyed. assessed through frequency questionnaire. All evaluated least one during...
Aim To study the effectiveness of a brief intervention (BI) associated with ASSIST (Alcohol Smoking and Substance Involvement Screening Test) for alcohol illicit drug use as part systematic screening program implemented in primary care. Design A multi-center randomized open-label trial stratified using ASSIST-specific substance involvement score (for alcohol, scores ranged from 11 to 15 16 20; other substances 4 12 13 20). Setting total 19 care centers (n = 520), eight emergency rooms 195)...
Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later life. NAFLD prevalence adolescents has increased significantly direct relation with obesity prevalence. Fatty become the most frequent indication for transplantation adults.The aim of study was identify anthropometric variables during first 10 years life associated risk developing adolescence.Longitudinal cohort 'Growth and Obesity Chilean Cohort...
Stigma toward people with mental health problems (MHP) in primary care (PHC) settings is an important public challenge. Research on stigma MHP relatively scarce Chile and Latin America, as are instruments to measure that validated for use there. The present study aims validate the Opening Minds Scale Health Care Professionals (OMS-HC) among staff providers Chilean PHC clinics, examine differences by sociodemographic characteristics.803 participants from 34 clinics answered a...
Abstract Background Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for hospitalized patients with COVID-19. We aimed to evaluate the efficacy and safety of early CP in COVID-19 progression. Methods Open-label, single-center, randomized clinical trial performed an academic center Santiago, Chile from May 10, 2020, July 18, final follow-up August 17, 2020. The included within first 7 days symptoms onset, presenting risk...
It has been reported in Chile that obesity figures children of 6- to 8-years-old are associated with height for age. We studied the possible influence perinatal variables on at controlling age.All 6-8 years age attending first grade public primary schools year 2005 were included. An historical cohort design was used and information collected birth obtained from National Registry. Obesity defined as BMI >or=95th percentile CDC reference. Comparisons prevalence contingency tables chi-squared...
Normal plasma insulin and HOMA values among chilean children adolescents
Background: The main aim is to determine the incidence and associated factors of late onset sepsis (LOS) in very low birth weight infants (500–1500 g), from NEOCOSUR Network during years 2001–2013. Secondary objectives are describe microbiology first second episode LOS study association between catheter dwell time LOS. Methods: Demographic information outcome data prospectively routinely collected across network using predefined diagnostic criteria online entry. was confirmed by isolation...