A5046556344- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Ovarian function and disorders
- Sexual Differentiation and Disorders
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Hypothalamic control of reproductive hormones
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Hormonal and reproductive studies
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Genetic Syndromes and Imprinting
- Neonatal Respiratory Health Research
- Hormonal Regulation and Hypertension
- Reproductive Physiology in Livestock
- Childhood Cancer Survivors' Quality of Life
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Sperm and Testicular Function
- Vitamin D Research Studies
University of Chile
2016-2025
Hospital San Borja Arriarán
1999-2013
National Research Center for Maternal and Child Health
2013
Boston Children's Hospital
2008
Hospital Luis Calvo Mackenna
2003
Tulane University
1997
University of Washington
1997
Strong associations between low birth weight and insulin resistance have been described. However, most of these studies retrospective. We aimed to determine whether infants born small for gestational age (SGA: <5th percentile age) decreased sensitivity, compared with appropriate (AGA: >10th percentile) at 1 yr age. studied blood lipids, fasting levels, other markers secretion during an iv glucose tolerance test in a cohort 85 SGA 23 AGA 1-yr-old infants. In addition, were stratified...
Objective. To study the consequences of low birth weight on glucose and lipid metabolism 48 hours after delivery. Methods. We studied 136 small for gestational age (SGA) 34 appropriate (AGA) term neonates who were born in Santiago, Chile. Prefeeding venous blood was obtained determination glucose, free fatty acids, β-hydroxy butyrate, insulin, C-peptide, leptin, sex hormone-binding globulin, insulin-like growth factor-binding protein-1 (IGFBP-1), cortisol. Results. SGA newborns had lower...
The criteria for diagnosis of polycystic ovary syndrome (PCOS) have been modified and now include morphology (PCOM).The purpose this study was to determine the frequency PCOS PCOM in women with type 1 diabetes mellitus (DM1).We evaluated clinical, hormonal, ultrasonographic characteristics DM1 compared them a carefully matched group normal cross-sectional study.The conducted at an academic research institute located within general hospital.All attending our hospital who had experienced...
Abstract Introduction: Insulin resistance (IR) develops as early age 1 to 3 yr in small for gestational (SGA) infants who show rapid catch-up postnatal weight gain. In contrast, greater insulin secretion is related infancy height gains. We hypothesized that IGF-I levels could be differentially gains length and also IR secretion. Methods: a prospective study of 50 SGA (birth &lt; 5th percentile) 14 normal birth [appropriate (AGA)] newborns, we measured serum at birth, yr, yr. (by...
The significance of polycystic ovarian morphology (PCOM) during adolescence is not clear. aim this study was to determine the relationship between PCOM and anti-Müllerian hormone (AMH), inhibin B, testosterone insulin levels in healthy girls second decade life. We also determined whether AMH could be used as a surrogate marker adolescence. Seventy-four non-obese adolescents (age range: 13.5−19.75 years old) with regular menstrual cycles participated study. Transabdominal ultrasound blood...
Serum anti-Müllerian hormone (AMH) levels decrease early during the transition to menopause and women with type 1 diabetes mellitus (DM1) experience at a younger age. We hypothesized that older DM1 will have lower AMH than controls. studied ovarian function in (n = 66) healthy controls 58), all <45 years old. Steroids, gonadotrophins, inhibin B were measured follicular phase. Piece-wise regression analysis demonstrated begin 33 of age both groups. This limit was used compare data >33 (4.1 ±...
Male patients with an extra sex chromosome or autosome are expected to present primary hypogonadism at puberty owing meiotic germ-cell failure. Scarce information is available on trisomy 21, a frequent autosomal aneuploidy. Our objective was assess whether 21 presents pubertal-onset, specific, in males, the established earlier and affects other testicular cell populations. We assessed functional status of pituitary-testicular axis, especially Sertoli function, 117 boys (ages: 2 months–20...
Adiponectin, a novel adipocytokine with insulin sensitizing properties, is inversely related to obesity and resistance in adults. We recently reported large variations weight gain sensitivity during the first year infants born small for gestational age (SGA) or appropriate (AGA). now determined whether adiponectin levels were postnatal growth prospective cohort followed from birth two years old (n = 85) (55 female/30 male, 65 SGA/20 AGA). Serum at one higher compared adults older children,...
Fetal exposure to maternal glucocorticoids may determine fetal growth and the programing of later disorders. Availability in placenta is regulated by 11beta-hydroxysteroid dehydrogenase (11beta-HSDs) enzymes. To date, there are discrepancies with regard cortisol (F) cord blood levels fetuses intrauterine retardation different species. Objective study expression activity 11beta-HSDs placentas from full term small for gestational age (SGA), appropriate (AGA) large (LGA) newborns,...
Context: Isolated hypospadias may result from impaired testicular function or androgen end-organ defects or, alternatively, hormone-independent abnormalities of morphogenetic events responsible for urethral seam.
In prepubertal children, low birth weight is related to reduced insulin sensitivity, particularly if a history of rapid postnatal gain present. We sought determine whether these associations were also evident in premature, very-low-birth-weight (VLBW) children. studied 60 VLBW children aged 5-7 yr (mean age 5.7 +/- 0.7 yr). Birth weights ranged from 690 1500 g 1195 31 g), with gestational ages between 25 and 34 wk (median 29 wk). A short iv glucose tolerance test was carried out assess...
Context: Anti-Mu ¨llerian hormone (AMH) levels are increased in polycystic ovarian syndrome (PCOS), but it is not known whether other forms of hyperandrogenism, such as PCOS observed women with type 1 diabetes mellitus (DM1), also associated elevated AMH levels.Objective: Our objective was to compare and steroid without DM1. Design:We compared the clinical, hormonal, ultrasonographic characteristics 17 DM1 (DM1ϩPCOS), 20 35 normal (control) a cross-sectional study. Results:The...
We evaluated the association of hirsutism and oligomenorrhea (persistent menstrual cycles > 45 days) as screening criteria for detection biochemical hyperandrogenism (BH) polycystic ovaries (PCOM) during adolescence determined which androgens, granulosa cell hormone, ultrasonographic parameters have best with ovary syndrome (PCOS). Hirsute girls (N = 26 Hirs/Oligo group) non-hirsute regular 63, C were studied. Prevalence BH PCOM, diagnostic performance androgens ultrasound PCOS diagnosis...
To analyze the nutritional status and plasma levels of vitamins minerals in a cohort Chilean children between 4 14 years old from three cities Chile (Santiago, Antofagasta, Concepcion).This is descriptive analysis micronutrient as it relates to obesity food consumption.This study included 1235 schools Santiago (central area), Antofagasta (northern Concepcion (southern area) Chile.Plasma micronutrients revealed deficiencies all these cities. Copper (26.4%) calcium (33.0%) were found whereas...
ABSTRACT Objective The relationship between biochemical premature adrenarche (PA) in girls and metabolic alterations during puberty it is well described. A part of these circulating androgens undergoes aromatization peripheral tissues to estrogens. This raises the question whether effects are due action or Our aim was assess levels urinary estrogens associated with risk at late stages without PA. Methods prospective observational study included 321 from Growth Obesity Chilean Cohort Study...
Premature adrenarche (PremA), is associated with increased adiposity and in girls to earlier puberty adverse metabolic profiles. Recently LC-MS/MS studies demonstrated adrenal production of more potent androgens: 11-oxygenated C19 steroids. Defining the mechanisms that regulate steroids has been elusive. We recently showed genetic determinants DHEAS during differed from those adulthood. One highly significant variant was at prolactin receptor which strongly expressed human tissue. The aim...
The present study aimed to investigate the role of nitric oxide (NO) in regression human corpus luteum. We therefore examined effect both NO and chorionic gonadotrophin (HCG) on luteal cell apoptosis, Bcl-2 production. oestrogen production during luteum was also studied. Slices from collected throughout phase were incubated for 4 h with synthase (NOS) substrate, l-arginine (l-Arg, 1 mmol/l), NOS inhibitor N-monomethyl-l-arginine (l-NMMA) (1 or HCG (10 IU/ml). Oestradiol concentrations...
Wide ranges in postnatal weight gain are seen infants born small for gestational age (SGA); most show some catch-up growth and this may be driven by increased appetite. Ghrelin, the natural ligand of GH secretagogue receptor, has potent orexigenic effects. In adults circulating ghrelin levels anorexia, decreased obesity post prandial suppression. The aim present study was to test hypothesis that rate over first year SGA relate variable suppression levels. Serum were measured 1 y old (n = 85)...
Elevated anti-Müllerian hormone (AMH) and adrenal androgen levels have been observed during childhood in girls at risk of developing polycystic ovarian syndrome (PCOS). The aim this study was to evaluate function steroid prepubertal with type 1 diabetes mellitus (T1D).Cross-sectional study. PATIENTS/MEASUREMENTS: We evaluated hormonal ultrasonographic characteristics T1D (N = 73) compared them found a control group healthy 86). Data are reported as geometric means (95% CI).Prepubertal had...
Context: An increased prevalence of polycystic ovary syndrome (PCOS) has been reported in adult women with type 1 diabetes mellitus (DM1). We investigated whether these hormonal abnormalities begin during puberty by evaluating the ovarian steroidogenic response to leuprolide acetate.
There are limited and controversial data concerning puberty characteristics in girls born small for gestational age (SGA).The objective of the study was to document clinical, ultrasonographic, biochemical at beginning matched healthy either SGA or appropriate (AGA) recruited from community.Inclusion criteria were breast Tanner stage II a body mass index between 10th 95th percentiles.Recruited subjects underwent complete physical exam, bone age, ultrasound measurements internal genitalia....