A5054625734- Ovarian function and disorders
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Reproductive Physiology in Livestock
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Literary and Cultural Studies
- Cancer Mechanisms and Therapy
- Classical Philosophy and Thought
- Angiogenesis and VEGF in Cancer
- Libraries, Manuscripts, and Books
- Cultural and Mythological Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and preeclampsia studies
- Philosophical Thought and Analysis
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Lipid metabolism and disorders
- Hormonal Regulation and Hypertension
- Caveolin-1 and cellular processes
- Endoplasmic Reticulum Stress and Disease
- Medieval and Classical Philosophy
University of Chile
2013-2023
Hospital Clínico de la Universidad de Chile
2013-2023
Universidad de Valladolid
2001-2018
University of California, Berkeley
2003-2016
Dominican School of Philosophy and Theology
2016
University of Puerto Rico System
2010
Hospital San Borja Arriarán
1998-2006
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder associated with insulin resistance and compensatory hyperinsulinemia. Scarce information available on the expression of molecules involved in pathway endometria from women PCOS. Therefore, we examined protein levels insulin-signaling molecules, like receptor, insulin-receptor substrate (IRS)-1, pIRS-1Y612, Akt, AS160, pAS160T642 GLUT4 PCOS or without Protein were assessed by Western blot immunohistochemistry 21...
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by hyperandrogenism and ovulatory dysfunction but also obesity hyperinsulinemia. These characteristics induce insulin-resistant state in tissues such as the endometrium, affecting its reproductive functions. Myo-inositol (MYO) insulin-sensitizing compound used PCOS patients; however, mechanism unclear. To understand relationship of MYO with insulin action endometrial cells, sodium/myo-inositol transporter 1...
Abstract Background Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside uterus. The fragments in normal menstruation are composed necrotic and living cells, which do not survive ectopic locations because programmed cell death. aim this study was to evaluate if balance between proliferation apoptosis changed eutopic endometrium from women with endometriosis throughout menstrual cycle studying bax (pro-apoptotic), c-myc (regulator...
Does treatment with the insulin sensitizer metformin modify levels and activation of proteins related to expression insulin-dependent glucose transporter (GLUT4), such as adenosine monophosphate-activated protein kinase (AMPK) myocyte enhancer factor 2A (MEF2A), in endometria from hyperinsulinemic hyperandrogenemic polycystic ovary syndrome (PCOS h-Ins) patients? In PCOS h-Ins patients, increases endometrial GLUT4 mRNA by normalizing quantity molecules that regulate healthy values. These...
Previous studies showed that nerve growth factor (NGF) induces the expression of functional FSH receptors (FSHR) in preantral follicles developing rat ovary.The objective this study was to determine whether NGF can affect granulosa cell (GC) function human periovulatory using intact ovaries and isolated GCs.Human GCs were obtained from vitro fertilization patients normal women with elective pelvic surgery for nonovarian indications.In ovaries, trkA (NGF's high-affinity receptor) detected by...
Acquisition of ovulatory competence by antral follicles requires development an adequate vascular supply. Although it is well established that ovarian angiogenesis cyclically regulated endothelial growth factor (VEGF), the factors controlling VEGF production remain largely unknown. Nerve (NGF) may be one these factors, because NGF promotes and synthesis angiogenic in other tissues produced human granulosa cells (hGCs).The aim study was to determine whether influences hGCs identify a...
Fifty to seventy percent of patients with polycystic ovary syndrome (PCOS) present hyperinsulinemia. On the other hand, reports indicate that forkhead box class O 1 (FOXO1) and peroxisome proliferator-activated receptor-γ (PPARG) are involved in insulin signaling pathway, regulating gene expression SLC2A4 (GLUT4). The negative effect FOXO1 over PPARG transcription disappears when is phosphorylated (p-FOXO1) excluded from nucleus, whereas can suppress SLC2A4. Scarce knowledge available...
Epithelial ovarian cancer (EOC) is a lethal gynecological neoplasia characterized by extensive angiogenesis and overexpression of nerve growth factor (NGF). Here, we investigated the mechanism which NGF increases vascular endothelial (VEGF) expression vasculogenic potential EOC cells, as well contribution cyclooxygenase 2/prostaglandin E2 (COX-2/PGE2) signaling axis to these events. biopsies cell lines were used determine COX-2 PGE2 levels, those potentially pro-angiogenic proteins c-MYC (a...
Abstract To evaluate the effect of reactive oxygen species in human corpus luteum function, we investigated whether hydrogen peroxide (H 2 O ) affects vitro luteal cell production steroids. H treatment (1·0–100 μ m mid and late cultures elicited a dose-dependent decrease basal progesterone production. However, cells with low concentration 0·01 significantly stimulated secretion ( P <0·05). In addition, (100 markedly inhibited chorionic gonadotropin (hCG)-stimulated estradiol secretion....