Background : Taxotere, a semisynthetic compound structurally related to taxol, has broad spectrum of activity in murine transplantable tumors; the B16 melanoma model, it caused total log cell kill 2.5 times greater than that by taxol at equitoxic doses. Purpose We conducted phase I study Taxotere ( ) determine its qualitative and quantitative toxic effects starting dose for II trials, b investigate clinical pharmacology, c document antitumor activity. Methods was given as 1-hour infusion 1...

The prevalence of epilepsy among children born in 1966 and reaching the age 9 years during 1975 was investigated Melipilla, Chile, using questions similar to those used by Rose et al. (1973). Of 2,104 potential respondents, 2,085 were interviewed. A sample 593 received neurological examination 455 an electroencephalogram. rates for higher than reported two American studies same methodology. possibility socioeconomic factors account these differences considered. Prevalence simple febrile...

Endometriosis is a benign gynecological pathology in which immune system deregulation may play role its initiation and progression. In endometriotic lesions, intercellular adhesion molecule-1 (ICAM1) released from the cell membrane by proteolytic cleavage of extracellular domain, process that coincides with increased expression activity metalloproteinases such as MMP1 MMP9. The objective our study was to investigate association between MMP9 activities ICAM1 mediated tumor necrosis factor...

This study compares the effect of tooth clenching and grinding on sternocleidomastoid electromyographic (EMG) activity during different laterotrusive jaw posture tasks. The included 28 healthy subjects with natural dentition bilateral molar support, 14 canine guidance group function. Bipolar surface electrodes were located left right muscles. EMG was recorded following tasks: A. eccentric from intercuspal position to lateral edge-to-edge contact position; B. in C. concentric position. On...

Summary Craniomandibular electromyographic ( EMG ) studies frequently include several parameters, e.g. resting, chewing and tooth‐clenching. activity during these parameters has been recorded in the elevator muscles, but little is known about respiratory muscles. The aim of this study was to compare obligatory accessory muscles between subjects with different breathing types. Forty male were classified according their type into two groups 20 each: costo‐diaphragmatic upper costal type....

The aim of this study was to determine the effect tooth clenching and grinding on anterior temporalis electromyographic (EMG) activity. sample included 30 healthy subjects with natural dentition bilateral molar support, 15 canine guidance group function. An inclusion criterion that have be free signs symptoms any dysfunction masticatory system. Bipolar surface electrodes were located left right muscles. EMG activity recorded during following conditions: A. eccentric from intercuspal position...

This study aimed to determine the expression of distinct matrix metalloproteinases, cytokines, and bone resorptive factors in temporomandibular joint osteoarthritis (TMJ-OA) patients their association with pain, mouth opening, subchondral degeneration.Twelve affected TMJ-OA (n = 5), disk displacement without reduction (DDWoR) 3), or (DDWR) 4) were selected. Joint pain was quantified by using visual analog scale, opening at maximum pain-free aperture, degeneration imaging. Synovial fluid...

This study was designed to determine the effect of occlusal scheme on masseter EMG activity at different jaw posture tasks. The sample included 30 healthy subjects with natural dentition and bilateral molar support, 15 canine guidance, group function. An inclusion criterion that had be free signs symptoms any dysfunction masticatory system. Bipolar surface electrodes were located left right muscles. recorded during following tasks: A. maximal clenching in intercuspal position; B. grinding...

This study compares the effect of clenching and grinding on masseter sternocleidomastoid electromyographic (EMG) activity during different jaw posture tasks in sagittal plane. The included 34 healthy subjects with natural dentition, Class I bilateral molar Angle relationship, absence posterior occlusal contacts mandibular protrusion. An inclusion criterion was that had to be free signs symptoms any dysfunction masticatory system. Bipolar surface electrodes were located right muscles. EMG...

Objectives: The aim of this study was to investigate whether the presence a natural mediotrusive contact influences electromyographic (EMG) pattern activity in patients with temporomandibular disorders (TMDs).Method: Bilateral surface EMG anterior temporalis (AT), masseter (MM), and sternocleidomastoid (SCM) muscles recorded 43 subjects during unilateral chewing tooth grinding. Thirteen had TMD (Group 1), 15 without 2), were healthy contacts 3). All examined according Research Diagnostic...

Background: Oral diseases remain among the most common non-communicable worldwide, affecting almost half of world’s population. This is partly because there has been a separation mouth from rest body and human health, psychological aspects such as personality, thoughts, emotions are not taken into account in dental office. The objective was to analyze relationship between oral health conditions personality traits adult patients who underwent treatment at Center for Health Studies Services....

The purpose of this study was to compare the electromyographic (EMG) activity anterior temporal and suprahyoid muscles using habitual methods determine clinical rest position. sample included 26 healthy subjects with natural dentition, bilateral molar support, Angle Class I occlusion. Bipolar surface electrodes were located on right for EMG recordings. In each subject recorded while standing performing following jaw posture tasks: during light occlusal contact in intercuspal position; after...

The preclinical pharmacology and pharmacokinetics of the natural marine product dolastatin 10 were investigated. Pharmacokinetics [3H]dolastatin determined in CD2F1 mice after intravenous, subcutaneous, intraperitoneal routes administration. After intravenous injection (0.24 mg/kg), plasma drug concentration declined rapidly was cleared from with a half-life 5.6 hr. subcutaneous dose 0.32 mg/kg, concentrations slowly rose to maximum 11 ng/ml then an elimination 3.7 Most radioactivity found...

With the objective of measuring prevalence and duration infertility in a developing country, retrospective cross-sectional study was designed. The survey conducted at Department Obstetrics Gynaecology, Hospital Sn. Borja-Arriaran, Mother Child Research Institute, University Chile, Santiago, March–September 1990. population comprised 474 women 15–45 years old selected random from 11 289 weddings that took place downtown 1982. reproductive history for preceding 8 obtained through home...

RESUMEN: Los órganos de los sentidos confieren a seres humanos la capacidad percibir y responder una gran gama estímulos que provienen del entorno, lo cual nos brinda facultad elaborar respuestas con el fin adaptarnos cambios medioambientales, cubrir nuestras necesidades básicas sobrevivir.Para nutrirnos, sentido gusto posee un rol primordial permite seleccionar dentro amplia variedad alimentos, las sustancias son necesarias para nuestro metabolismo, protegiéndonos su vez compuestos...

Objective: To evaluate the activity of mentalis (MN), buccinator (BC), and suprahyoid (SH) muscles among participants with different lip competence..Methods: Sixty-three were classified clinically assigned to following groups 21 each: 1) competent lips (competent), 2) incompetent (incompetent), or 3) forced closure (forced). Activity was recorded at rest, swallowing, speaking, reciprocal compression lips, chewing.Results: MN in significantly higher than it when compared during swallowing (p<...

Abstract Background The envelope of motion is a diagrammatic representation the mandibular border movements. Classically, those movements are carried out eccentrically; starting from position maximal intercuspation, mandible describes an excursion movement until reaching mouth opening. Reverse would describe different path, but up to now concentric development has not been considered. Literature states that beyond limits, no possible. Therefore, it great interest compare both paths—both...

The aim of this study was to evaluate the anterior temporalis and suprahyoid electromyographic (EMG) activity during jaw clenching tooth grinding at different posture tasks. included 30 healthy subjects with natural dentition bilateral molar support, incisive protrusive guidance laterotrusive canine guidance. Bipolar surface electrodes were located on right muscles. Three EMG recordings in standing position performed following tasks: C. intercuspal (IP); P1. eccentric from IP edge-to-edge...

Objective. This study evaluated the effect of a natural mediotrusive contact on electromyographic (EMG) activity anterior temporalis and sternocleidomastoid muscles during chewing in healthy subjects. Materials methods. The sample included two groups 15 subjects each (Group 1: with contact; Group 2: without contact). Bilateral surface EMG was recorded unilateral half cookie piece apple. Anterior muscle normalized against maximal voluntary clenching intercuspal position intentional isometric...

The goal of this study was to evaluate the electromyographic (EMG) activity anterior temporalis, suprahyoid, infrahyoid and trapezius muscles during tooth grinding at different jaw posture tasks.Participants were 30 healthy subjects with natural dentition, bilateral molar support incisive protrusive guidance. Bipolar surface electrodes located on right side subject. EMG recordings performed in following tasks: (A) Eccentric from intercuspal position edge-to-edge contact position; (B)...