A5038419640- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrest and Resuscitation
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Parasitic infections in humans and animals
- Trauma and Emergency Care Studies
- Hemoglobinopathies and Related Disorders
- COVID-19 and Mental Health
- Pharmacogenetics and Drug Metabolism
- Congenital Anomalies and Fetal Surgery
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutrition, Health and Food Behavior
- Chronic Myeloid Leukemia Treatments
- Pain Management and Opioid Use
- Intensive Care Unit Cognitive Disorders
Pontificia Universidad Católica de Chile
2015-2024
McLaren Macomb
2022
Memorial Sloan Kettering Cancer Center
2022
Henry M. Jackson Foundation
2020
IQVIA (United States)
2019
Uniformed Services University of the Health Sciences
2018
Instituto de Investigación Sanitaria La Fe
2013-2017
Hospital Universitari i Politècnic La Fe
2013-2016
Mayo Clinic
2014
National University of San Marcos
2013
Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for hospitalized patients with COVID-19. We aimed to evaluate the efficacy and safety of early CP in COVID-19 progression.The study was an open-label, single-center randomized clinical trial performed academic medical center Santiago, Chile, from May 10, 2020, July 18, final follow-up until August 17, 2020. The included within first 7 days symptom onset, presenting risk factors...
Aim: In order to identify genetic variants associated with taxanes toxicity, a panel 47 SNPs in 20 genes involved taxane pathways was designed. Patients & methods: Genomic DNA of 113 breast cancer patients analyzed (70 taking docetaxel, 43 paclitaxel). Results: Two docetaxel toxicity were identified: CYP3A4*1B infusion-related reactions; and ERCC1 Gln504Lys mucositis (p ≤ 0.01). Regarding paclitaxel toxicity: CYP2C8 HapC rs1934951 anemia; neuropathy Conclusion: Genes repair mechanisms...
The objective was to determine whether brief, Web-based instruction several weeks prior tourniquet application improves layperson success compared utilizing just-in-time (JiT) instructions alone.Stop the Bleed is a campaign educate laypeople stop life-threatening hemorrhage. It based on U.S. military experience with lifesaving use. While previous research shows simple JiT boost laypeople's application, optimal approach public not yet known.This prospective, nonblinded, randomized study....
Anthracycline uptake could be affected by efflux pumps of the ABC family. The influence 7 SNPs genes was evaluated in 225 adult de novo acute myeloid leukemia (AML) patients. After multivariate logistic regression there were no significant differences complete remission, though induction death associated to ABCB1 triple variant haplotype (p = .020). related higher nephrotoxicity .016), as well this and allele rs1128503, rs2032582 hepatotoxicity .001; p .049; < .001). Furthermore, ABCC1...
Abstract Background Convalescent plasma (CP), despite limited evidence on its efficacy, is being widely used as a compassionate therapy for hospitalized patients with COVID-19. We aimed to evaluate the efficacy and safety of early CP in COVID-19 progression. Methods Open-label, single-center, randomized clinical trial performed an academic center Santiago, Chile from May 10, 2020, July 18, final follow-up August 17, 2020. The included within first 7 days symptoms onset, presenting risk...
Purpose Trastuzumab (TZM) improves survival and the risk of recurrence among patients with early-stage HER2+ breast cancer (BC). TZM treatment can be given intravenously (IV-TZM) or subcutaneously (SC-TZM). Although both methods have similar efficacy safety, they differ in dosage administration. Previous studies cost minimization determined that SC-TZM is associated lower costs than IV-TZM; however, those did not include body weight-based adverse drug reactions (ADRs). Methods/Patients We...
Background: Lung hydatid cyst caused by Echinococcus granulosus is endemic in many areas of the world. We aimed to compare outcome surgical treatment intact and ruptured (infected or noninfected) cysts. Methods: reviewed medical records 115 patients with lung disease who were surgically treated between 2001 2005 a tertiary hospital Lima, Peru. Patients divided into 3 groups based on characteristics: cysts (n = 41), noninfected 47) infected 27). If patient had more than one type cyst, most...
Basic cardiopulmonary resuscitation: knowledge, practical skills and effectiveness of maneuvers general physiciansBackground: General physicians should be adequately trained to deliver effective resuscitation during ventricular fibrillation (VF).Aim: To assess the degree in (CPR) Chilean physicians.Materials Methods: Forty eight starting Anesthesiology or Internal Medicine residency programs were evaluated.They answered a modified American Heart Association Life Support Course written test...
Aim: Studying the possible influence of SNPs on efficacy and safety calcineurin inhibitors upon heart transplantation. Materials & methods: In 60 transplant patients treated with tacrolimus or cyclosporine, we studied a panel 36 correlated series clinical parameters during first post-transplantation year. Results: The presence serious infections was to ABCB1 rs1128503 (p = 0.012), CC genotype reduced probability being also associated lower blood cyclosporine concentrations. Lower renal...
Cytarabine is considered the most effective chemotherapeutic option in acute myeloid leukemia (AML). The impact of 10 polymorphisms cytarabine metabolic pathway genes were evaluated 225 adult de novo AML patients. Variant alleles DCK rs2306744 and CDA rs602950 showed higher complete remission (p = .024, p .045), with lower survival rates for variant rs2072671 .015, .045, .032), rs3215400 .033) wild-type genotype .039, .014). Induction death .021, .047) correlated to RRM1 rs9937 allele. In...