A5101978605- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Anesthesia and Neurotoxicity Research
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Alcoholism and Thiamine Deficiency
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Electrolyte and hormonal disorders
- Heart Failure Treatment and Management
- Renal function and acid-base balance
- Healthcare Decision-Making and Restraints
- Vitamin C and Antioxidants Research
- Acute Kidney Injury Research
- Healthcare Policy and Management
- Pharmacovigilance and Adverse Drug Reactions
- Atrial Fibrillation Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Cardiac Arrest and Resuscitation
University of Southampton
2023-2025
Jackson Memorial Hospital
2025
King's College London
2014-2024
NIHR Southampton Biomedical Research Centre
2023-2024
University Hospital Southampton NHS Foundation Trust
2023-2024
South London and Maudsley NHS Foundation Trust
2023
Maudsley Hospital
2023
King's College Hospital NHS Foundation Trust
2019-2023
Wilkes University
2023
Queen's University
2023
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in achieves concentrations associated maximal activity affect patient outcome.This was prospective, multinational pharmacokinetic point-prevalence study including 8 antibiotics. Two blood samples were taken from each during single interval. The primary pharmacokinetic/pharmacodynamic targets free above the minimum inhibitory...
OBJECTIVES: To provide guidance on the reporting of norepinephrine formulation labeling, in publications, and use clinical practice. DESIGN: Review task force position statements with necessary guidance. SETTING: A series group conference calls were conducted from August 2023 to October 2023, along a review available evidence scope problem. SUBJECTS: multinational multidisciplinary critical care experts assembled by Society Critical Care Medicine European Intensive Medicine. INTERVENTIONS:...
Abstract Background The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability RRT techniques and antibiotic relate observed trough concentrations to targets. Methods We performed a prospective, observational, multinational, pharmacokinetic study 29 intensive care units from 14 countries. collected demographic, clinical, data. measured meropenem, piperacillin-tazobactam, vancomycin related...
Background Financial toxicity refers to financial hardship experienced because of illness or injury. Poverty is a known driver community violence, but has not been studied in firearm violence survivors. The objective our study was explore the needs survivors enrolled hospital-based intervention program (HVIP). We hypothesized that would report numerous needs. Methods This mixed-methods, retrospective Miami-Dade County HVIP from 2022 2023. Patients were eligible for enrollment if they injured...
Objective Patients with autoimmune hepatitis (AIH) receive variable corticosteroid and thiopurine regimens. Our aim was to undertake a cohort study determine whether earlier introduction of azathioprine allowed reduction in cumulative burden. We also determined temporal trends treatment choices outcomes. Method 226 adults AIH treated from 1970 2020 at Kings College Hospital were divided into two groups: patients who received therapy within 8 weeks initiation (early group, n=106) had more...
To evaluate the cost-effectiveness of caspofungin vs. liposomal amphotericin B in treatment suspected fungal infections UK.The was evaluated using a decision-tree model. The decision tree populated both data and clinical definitions from published studies. Model outcomes included success terms resolution fever, baseline infection, absence breakthrough survival quality adjusted life years (QALYs) saved. Discontinuation due to nephrotoxicity or other adverse events were Efficacy safety based...
Abstract Introduction Midazolam is used routinely to sedate patients in the intensive care unit (ICU). We suspected that midazolam over-sedation was occurring ICU of Guy's and St. Thomas' Trust it could be difficult differentiate this from underlying neurological damage. A sensitive assay for detecting 1-hydroxymidazolam glucuronide (1-OHMG) serum developed applied clinical setting. Methods In present study we evaluated a series cases managed mixed medical, surgical trauma ICU. Serum...
Abstract Purpose Clinical pharmacist (CP) interventions from the PROTECTED-UK cohort, a multi-site critical care study, were further analysed to assess effects of: time on care, number of interventions, CP expertise and days week, impact intervention ultimately contribution patient care. Methods Intervention data collected 21 adult units over 14 days. Interventions could be error, optimisation or consults, blind-coded ensure consistency, prior bivariate analysis. Pharmacy service...
Iatrogenic withdrawal syndrome, after exposure medication known to cause is recognised, yet under described in adult intensive care.To investigate, opioid, sedation, and preadmission practice critically ill adults with focus on aspects associated iatrogenic syndrome.One-day point prevalence study UK care units (ICUs). We collected ICU admission and/or substances potential, sedation policy, opioid sedative use, dose, duration.Thirty-seven from 39 participating ICUs contributed data 386...
<b><i>Background/Aims:</i></b> Citrate is an effective anticoagulant during continuous renal replacement therapy (CRRT). Previous studies showed raised parathyroid hormone (PTH) levels when aiming for serum ionized calcium [Ca<sub>i</sub>] between 0.8 and 1.1 mmol/l. Our objective was to assess whether citrate-based CRRT with physiologic target systemic 1.12 1.20 mmol/l could maintain stable PTH levels. <b><i>Methods:</i></b>...
Significant errors can be made during medication prescribing, dispensing and administration. One source of error potential for harm is unintentional omission. Medicines reconciliation seeks to reduce the impact this between transfer care. In long-term hypothyroidism, patients are dependent upon levothyroxine there few contraindications its prescription. We considered prescription in hypothyroidism as a marker medicines on admission stay intensive care unit (ICU).A retrospective chart review...
Aim Timely access to treatment in the early stages of mental illness is pivotal recovery and prevention longer‐term disablement. Yet, this can be challenging at times growing service demands. The headspace Brief Interventions Clinic (BIC) an innovative model aiming promote quick evidence‐based interventions for young people presenting with signs disorders. Methods BIC package comprises eight skill‐building behavioural intervention modules that choose from. Treatment occurs over a maximum six...
Abstract Objective Clinical pharmacists reduce medication errors and optimize the use of in critically ill patients, although actual staffing level deployment UK is unknown. The primary aim was to investigate clinical pharmacy workforce critical care compare this with published standards. Methods An electronic data entry tool created distributed for services record their data. Key findings Data were received 279 units 171 organizations. pharmacist input identified 98.6% units. median weekday...
Delirium affects up to 80% of patients admitted intensive care units (ICUs) and contributes increased morbidity mortality. Haloperidol is the gold standard for treatment, although quetiapine has been successfully used in management delirium.We conducted a retrospective study ICU between February 2008 May 2010 who were prescribed by attending clinician. Data collected included demographics, history drug and/or alcohol dependence, hospital length stay, mechanical ventilation duration treatment...