A5065596984- Viral Infections and Vectors
- Aging, Health, and Disability
- Healthcare Systems and Reforms
- Healthcare Policy and Management
- Migration, Health and Trauma
- Health and Lifestyle Studies
- Fire effects on ecosystems
- Global Maternal and Child Health
- Migration, Education, Indigenous Social Dynamics
- Viral Infections and Outbreaks Research
- Climate Change and Health Impacts
- Maternal and Neonatal Healthcare
- Chronic Disease Management Strategies
- Acute Ischemic Stroke Management
- Respiratory Support and Mechanisms
- Renal Transplantation Outcomes and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Public Health and Social Inequalities
- Bladder and Urothelial Cancer Treatments
- Dialysis and Renal Disease Management
- Health disparities and outcomes
- COVID-19 Clinical Research Studies
- Knee injuries and reconstruction techniques
- Stress and Burnout Research
- Mosquito-borne diseases and control
Universidad del Desarrollo
2016-2025
Clínica Alemana
2016-2025
Boston University
2020-2024
Universidad del Desarrollo del Estado de Puebla
2024
University of South Carolina
2022
Hospital Padre Hurtado
2019
Ministry of Health
2010-2019
Autonomous University of Tamaulipas
2018
University of York
2017
University of Chile
2010-2017
Andes virus (ANDV) infection, which has a case fatality rate of 37% in Chile, often occurs household clusters and may be transmitted from person to person.To determine the incidence risk factors for additional cases, we conducted prospective study among recent contacts persons with hantavirus cardiopulmonary syndrome (HCPS) including testing serum anti-hantavirus antibodies blood cells ANDV RNA by reverse-transcription polymerase chain reaction (RT-PCR).We enrolled 76 index patients 476...
Background. Andes virus (ANDV)–related hantavirus cardiopulmonary syndrome (HCPS) has a 35% case fatality rate in Chile and no specific treatment. In an immunomodulatory approach, we evaluated the efficacy of intravenous methylprednisolone for HCPS treatment, through parallel-group, placebo-controlled clinical trial. Methods. Patients aged >2 years, with confirmed or suspected stage, admitted to any 13 study sites Chile, were randomized by center blocks 4 1:1 allocation assigned sequentially...
Chile's 'health guarantees' approach to providing universal and equitable coverage for quality healthcare in a dual public-private health system has generated global interest. The programme, called AUGE, defines legally enforceable rights explicit benefits priority conditions, which incrementally covered 56 problems representing 75% of the disease burden between 2005 2009. It was accompanied by other reform measures increase public financing sector planning secure guarantees nationwide, as...
In Chile, Andes virus (ANDV) is the sole aetiological agent of hantavirus cardiopulmonary syndrome (HCPS) with mean annual incidence 55 cases, 32% case fatality rate (CFR) and no specific treatment. Neutralizing antibody (NAb) titres at hospital admission correlate inversely HCPS severity. We designed an open trial to explore safety efficacy evaluate pharmacokinetics immune plasma as a treatment strategy for this disease.We performed plasmapheresis on donors least 6 months after measured NAb...
Chromosome 22q11.2 deletion is the most commonly occurring known microdeletion syndrome. Deaths related to syndrome have been reported, but magnitude of death has not quantified. This study evaluated deletion's impact on survival and its clinical manifestations in a large cohort Chilean patients.Demographic data individuals with 22q11 deletions diagnosed between 1998 2013 were collected from medical records certificates. Case fatality rate was calculated compared national vital statistics....
Kisspeptin regulates reproduction via signaling through the receptor, Kiss1r, in GnRH neurons. However, both kisspeptin and Kiss1r are produced several peripheral tissues, recent studies have highlighted a role for metabolism glucose homeostasis. We recently reported that knockout (KO) mice display sexually dimorphic metabolic phenotype, with KO females displaying obesity, impaired metabolism, intolerance at 4-5 months of age. it remains unclear when this phenotype first emerges development,...
Abstract Background Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates seroprevalence in HCWs. Longitudinal assessments the serological response Covid-19 among HCWs crucial understanding infection and changes antibody titers over time. We aimed investigate factors associated with seroconversion a prospective cohort during peak first wave pandemic. Methods conducted longitudinal study 446 front-line HCWsin tertiary-care...
Introduction and Objectives: Multimorbidity, defined as the coexistence of two or more chronic conditions, poses significant challenges in healthcare by affecting patient outcomes increasing costs. This study aimed to evaluate multimorbidity’s impact on patients with genitourinary cancer (GUC) Chile, focusing prevalent comorbidities, their combinations, association hospitalization severity. Materials Methods: A retrospective, population-based was conducted using data from Fondo Nacional de...
Abstract Introduction Acute respiratory distress syndrome (ARDS) is a severe condition with high morbidity and mortality, characterized by significant clinical heterogeneity. This heterogeneity complicates treatment selection patient inclusion in trials. Therefore, the objective of this study to identify physiological subphenotypes ARDS using machine learning, determine ventilatory variables that can effectively discriminate between these bedside setting performance, highlighting potential...
Arsenic chronic exposure, particularly in its inorganic form, represents a significant public health concern. This study was conducted Arica, the northernmost city country, whose inhabitants have been exposed to arsenic both naturally through drinking water and anthropogenically due toxic waste disposal site. We explored changes levels cohort of pregnant women their children over decade, identifying exposure trends determinants. used data on maternal urine samples during pregnancy, collected...
Abstract The potential incubation period from exposure to onset of symptoms was 7–39 days (median 18 days) in 20 patients with a defined Andes virus high-risk area. This 14–32 11 for <48 hours.
<h3>Background:</h3> The NIH Stroke Scale (NIHSS) is used to assess acute ischemic stroke severity and outcome. High NIHSS scores are usually associated with arterial occlusion but it unknown what the effect of time clinical evaluation (TTCE) in this association is. We tested as an instrument determine vessel (VO) at different points from symptom onset. <h3>Methods:</h3> Patients were selected our prospective database if they had admission intracranial neuroimaging studies. dichotomized...
Achieving a symmetrical power performance (difference <15%) between lower limbs is generally recommended during sports rehabilitation. However, athletes in single-leg-dominant sports, such as professional soccer players, could develop significant asymmetry their dominant and nondominant legs, that symmetry does not act viable comparison.To (1) compare maximal muscular the legs healthy young adults, (2) evaluate effect of sport activity performed at level, (3) propose parameter normality for...
Abstract Background Mortality from chronic kidney disease of unknown etiology (CKDu) is extremely high along the Pacific coast Central America, particularly among sugarcane workers. The Mesoamerican Nephropathy Occupational Study (MANOS) a prospective cohort study CKDu agricultural and non-agricultural workers in El Salvador Nicaragua. objective this manuscript to describe MANOS recruitment, baseline data collection, prevalence after two rounds. Methods Workers with no known diabetes,...
Abstract Background There is growing attention on occupational heat stress in Central America, as workers this region are affected by a unique form of chronic kidney disease. Previous studies have examined wet bulb globe temperatures and estimated metabolic rates to assess stress, but there limited data characterizing strain among these workers. Objective The aims were characterize examine whether job task, break duration, hydration practices, function associated with strain. Methods We used...
Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men Mesoamerica. Strenuous agricultural labor consistent risk factor for MeN, but the pathophysiologic mechanism leading to poorly understood. We compared urine metabolome among Nicaragua engaged sugarcane harvest and seed cutting (n = 117), group at high against three referents: Nicaraguans working less strenuous jobs same plantations 78); performing non-agricultural work 102); workers Spain 78)....
<h3>BACKGROUND:</h3> Ventilatory inefficiency increases ventilatory demand; corresponds to an abnormal increase in the ratio of minute ventilation (V̇<sub>E</sub>) CO<sub>2</sub> production (V̇<sub>CO<sub>2</sub></sub>); represents increased dead space, deregulation respiratory control, and early lactic threshold; is associated with expiratory flow limitation that enhances dynamic hyperinflation may limit exercise capacity. <h3>OBJECTIVE:</h3> To evaluate influence over capacity COPD...