A5082757383- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Regulation of Appetite and Obesity
- Facial Rejuvenation and Surgery Techniques
- Stroke Rehabilitation and Recovery
- Kruppel-like factors research
- Luminescence and Fluorescent Materials
- Facial Nerve Paralysis Treatment and Research
- Ferroptosis and cancer prognosis
- Insect and Pesticide Research
- Neurological Disease Mechanisms and Treatments
- Bacteriophages and microbial interactions
- Supramolecular Chemistry and Complexes
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Biochemical Analysis and Sensing Techniques
- Insect Resistance and Genetics
- Sleep and Wakefulness Research
- MicroRNA in disease regulation
- Photochromic and Fluorescence Chemistry
- Galectins and Cancer Biology
- Supramolecular Self-Assembly in Materials
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
Lanzhou University
2025
Tianjin Medical University
2025
Zhejiang Provincial People's Hospital
2019-2024
Sun Yat-sen University
2019-2024
Chinese University of Hong Kong
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Zhuhai People's Hospital
2024
Jinan University
2023-2024
Hangzhou Medical College
2019-2024
Abstract Chemoresistance is a major cause of cancer progression and the mortality patients. Developing safe strategy for enhancing chemosensitivity challenge biomedical science. Recent studies have suggested that vitamin D supplementation may decrease risk many cancers. However, role in chemotherapy remains unknown. We found sensitised oral cells to cisplatin partially reversed resistance. Using RNA-seq, we discovered lipocalin 2 (LCN2) an important mediator. Cisplatin enhanced expression...
A correction to this paper has been published and can be accessed via a link at the top of paper.
Background: Evidences indicate that exosomes-mediated delivery of microRNAs (miRNAs or miRs) is involved in the neurogenesis stroke. This study was to investigate role exosomal miRNAs non-drug therapy electro-acupuncture (EA) regulating endogenous neural stem cells for stroke recovery. Methods: The model focal cerebral ischemia and reperfusion rats were established by middle artery occlusion (MCAO) treated EA. exosomes extracted from peri-ischemic striatum identified biomarkers, detected...
MicroRNAs (miRNAs) have been recently found in the mitochondria, and were named "mitomiRs", but their function has remained elusive.Here, we aimed to assess presence function(s) of mitomiRs tongue squamous cell carcinoma (TSCC).Methods: miRNA microarray was performed paired TSCC lines, Cal27 its chemoresistant counterpart, Cal27-re.Decreased expression cells characterized.The functions investigated by a series vitro vivo experiments.Results: Differential analysis identified downregulation...
// Xiao-Bin Cui 1, 2, * , Su Li 3, Ting-Ting Hao Peng 1 Jin Shu-Mao Zhang Chun-Xia Liu Lan Yang Yao-Yuan Shen 4 Shu-Gang Na 5 Yong 6 Jian-Ming Hu Jin-Fang Jiang Jing Suo Yan Qi Wei-Hua Liang Liang-Hai Wang Hong-Wei Dang Wei-Wei Cao 7 Yutao Wei 8 Laibo-Yin Chuan-Yue Wu 9 Xiang-Lin Yuan 2 Hong Zhou 10 Yu Zheng Yun-Zhao Chen Feng Department of Pathology and Key Laboratory for Xinjiang Endemic Ethnic Diseases, Shihezi University School Medicine, Shihezi, China Oncology, Tongji Hospital, Huazhong...
Chronic kidney disease (CKD) is a global health challenge associated with lifestyle factors such as diet, alcohol, BMI, smoking, sleep, and physical activity. Metabolomics, especially nuclear magnetic resonance(NMR), offers insights into metabolic profiles' role in diseases, but more research needed on its connection to CKD factors. Therefore, we utilized the latest metabolomics data from UK Biobank explore relationship between plasma metabolites factors, well investigate associations...
Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration RA pathogenesis still mystery. Collagen induced (CIA) in rats an established model that shares many similarities with humans. In this study we investigated effect on CIA rats. was developed Sprague-Dawley (S.D) (n = 60, female) and used as resembling Rats were treated high or moderate dose Bi-Qi, methotrexate...
Development of resistance in target pests is a major threat to long-term use transgenic crops expressing Bacillus thuringiensis (Bt) Cry toxins. To manage and/or delay the evolution insects through implementation effective strategies, it essential understand basis resistance. One most important mechanisms insect Bt alteration interactions between toxins and their receptors midgut. A Cry1Ac-selected strain Asian corn borer (ACB), Ostrinia furnacalis, key pest maize China, evolved three mutant...
Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations have identified an ESCC susceptibility locus within the SLC39A6 gene. Here, we sought to explore expression biological function of ESCC.Multiethnic validation protein was performed different cohorts patients from Kazakh Xinjiang region by immunohistochemistry. The associations among...
To analyse the correlation between serum human beta-defensin-2 (hBD-2) levels and response to JAK inhibitor in psoriasis.We evaluated psoriasis area severity index (PASI) hBD-2 of 18 patients randomized receive placebo or tofacitinib 5 10 mg b.i.d. at baseline, week 8, 16. Serum were measured by enzyme-linked immunosorbent assay (ELISA).The PASI achieved a dramatic reduction after treatment for 16 weeks (p < 0.05). significantly decreased treated with compared baseline placebo-treated A...
Volatile organic compounds (VOCs) play important roles in the regulation of plant growth and pathogen resistance. However, little is known about influence VOCs released from endophytic strains (Burkholderia pyrrocinia strain JK-SH007) on controlling pathogens or inducing systemic resistance poplar. In this study, we found that produced by JK-SH007 inhibit three poplar canker (Cytospora chrysosperma, Phomopsis macrospora, Fusicoccum aesculi) promote defense enzyme activity malondialdehyde...
The transition of macrophages from the proinflammatory M1 to anti-inflammatory M2 phenotype is crucial during wound healing process. In this study, we assess role chemokine (C-C motif) ligand 6 (CCL6) in modulating macrophage polarization and healing. Initially, observed significantly upregulated CCL6 expression skin tissue on edge inflammation proliferation phases. Furthermore, discovered that mice treated with rCCL6 had accelerated increased levels M2-type macrophages. Using vitro models,...
Bacillus subtilis is widely used in agriculture and industrial biotechnology; however, cell autolysis significantly decreases its yield liquid cultures. Numerous factors mediate the lysis of B. subtilis, such as cannibalism factors, prophages, peptidoglycan (PG) hydrolases. The aim this work was to use molecular genetic techniques develop a new strategy prevent enhance biomass well production recombinant proteins.Five genes or elements representing three different functional categories were...
A photolocking strategy is described to achieve the construction of effectively photoswitchable quadruple hydrogen bonds featuring with photoregulable H-bonding affinities, which further applied in photocontrollable H-bonded self-assemblies.
Pear (Pyrus bretschneideri) is characterized by being self-incompatible and dependent on cross-pollination to set fruit. Honeybee (Apis mellifera) considered the most important pollinator of pear. Nevertheless, limited pollen transfer has been cited as main cause poor fruit in many pear orchards. Here, we tested following hypotheses: (i) colony manipulations increase collection tendency honeybees (ii) proportion loads returned hive from target plant. The technique reliably rapidly estimates...
Abstract In recent years, researchers have explored the interlayer stacking structure of bilayer (BL) transition metal dichalcogenides (TMDCs) and found that it has unique impact on electrical, optical, vibrational properties TMDCs. Unfortunately, size BL TMDCs synthesized by pre-existing methods is not large. addition, there any effective mean to control number layers as well stack structure. This major limiting factor for further exploration We report a new method rapid controllable growth...
The role of human papillomavirus (HPV) may be involved in the development esophageal cancer (EC) and polymorphic immune response gene transporter associated with antigen processing (TAP) HPV persistence subsequent carcinogenesis. current study aims to provide association evidence for EC, investigate TAP1 polymorphisms EC assess its statuses Kazakhs. genotypes 361 patients 66 controls selected from Kazakh population were evaluated using PCR. Polymerase chain reaction-restriction fragment...