A5101812354- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Eicosanoids and Hypertension Pharmacology
- RNA modifications and cancer
- Pain Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Inhalation and Respiratory Drug Delivery
- Cancer Genomics and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Infectious Diseases and Tuberculosis
- Free Radicals and Antioxidants
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- biodegradable polymer synthesis and properties
- Musculoskeletal Disorders and Rehabilitation
- Silymarin and Mushroom Poisoning
- Thyroid Disorders and Treatments
- Virus-based gene therapy research
- Diagnosis and treatment of tuberculosis
- Erythrocyte Function and Pathophysiology
- Protein Kinase Regulation and GTPase Signaling
- Pleural and Pulmonary Diseases
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
Tianjin Medical University General Hospital
2022
Inner Mongolia Medical University
2015-2022
Tianjin Medical University
2022
Hebei Medical University
2019
Third Hospital of Hebei Medical University
2019
Goethe University Frankfurt
2012-2017
Shihezi University
2014-2015
Dalian Medical University
2012-2014
Liaoning Ocean and Fisheries Research Institute
2012
Significance Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe side effect that affects up to 80% of patients during cancer treatment. Pharmacological treatment options are poor, as CIPNP differs mechanistically from other chronic states. Here, we describe mechanism by which pronociceptive oxidized lipid mediators generated the cytochrome P 450 -epoxygenase CYP2J2 in sensory neurons CIPNP. Blocking synthesis these lipids with telmisartan, identified potent inhibitor large...
// Xiao-Bin Cui 1, 2, * , Su Li 3, Ting-Ting Hao Peng 1 Jin Shu-Mao Zhang Chun-Xia Liu Lan Yang Yao-Yuan Shen 4 Shu-Gang Na 5 Yong 6 Jian-Ming Hu Jin-Fang Jiang Jing Suo Yan Qi Wei-Hua Liang Liang-Hai Wang Hong-Wei Dang Wei-Wei Cao 7 Yutao Wei 8 Laibo-Yin Chuan-Yue Wu 9 Xiang-Lin Yuan 2 Hong Zhou 10 Yu Zheng Yun-Zhao Chen Feng Department of Pathology and Key Laboratory for Xinjiang Endemic Ethnic Diseases, Shihezi University School Medicine, Shihezi, China Oncology, Tongji Hospital, Huazhong...
Peripheral sensitization during inflammatory pain is mediated by a variety of endogenous proalgesic mediators including number oxidized lipids, some which serve modulators sensory TRP-channels. These lipids are eicosanoids the arachidonic acid and linoleic pathway, as well lysophophatidic acids (LPAs). However, their regulation pattern contribution to peripheral still unclear. Here, we used UVB-model for investigate alterations lipid concentrations at site inflammation, dorsal root ganglia...
Sensitization of the heat-activated ion channel transient receptor potential vanilloid 1 (TRPV1) through lipids is a fundamental mechanism during inflammation-induced peripheral sensitization. Leukotriene B4 proinflammatory lipid mediator whose role in nociceptive sensitization not well understood to date. Two major G-protein-coupled receptors for leukotriene have been identified: high-affinity BLT1 and low-affinity BLT2. Transcriptional screening expression murine dorsal root ganglia showed...
Abstract FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-phosphate (S1P) receptor agonist. has been shown to reduce the nociceptive behavior in paclitaxel model for chemotherapy-induced neuropathic pain through downregulation of S1P 1 (S1P1) microglia spinal cord. Here, we investigated mechanisms underlying antinociceptive effects trauma-induced pain. We found that intrathecal administration phosphorylated (FTY720-P)...
Oxidized low-density lipoprotein (ox-LDL) is well recognized to play a key role in the development of atherosclerosis. And influenza virus infection has been also promote atherosclerosis onset and progressing. However, little known about mechanism into it. In present study, we investigated A/Porto Rico/8/1934 (H1N1) (PR8) human endothelial Eahy926 cells, determined induction apoptosis by cell. Then induced ox-LDL influence on ox-LDL-induced cells. Results demonstrated that PR8 infected...
Abstract Distant metastasis is one of the leading causes lung cancer death. Detecting early‐stage molecular alternations in primary tumors, such as gene expression differences, provides a “prognostic” value to precaution tumor metastasis. The aim this article screen and identify metastasis‐related genes human squamous cell carcinoma. Primary tissues nine patients with subsequent eight without were selected perform microarray experiment. GO pathway analyses used determine differentially...
This case report describes a of an unusual initial presentation acute lymphoblastic leukemia in previously healthy 15-year-old boy. He initially presented with 6-day history tiredness, decreased oral intake, nausea, vomiting, and jaundice (yellow sclera dark urine) evidence hepatic failure, presenting as increase alanine aminotransferase (ALT)/aspartate (AST)/total bilirubin decrease prothrombin activity. A complete serological evaluation for liver disease was negative. The levels serum AST...
Purpose OLC1 was recently identified to be a potential oncogene. However, the role of in human esophageal cell carcinoma (ESCC) is unknown. The aim this study therefore evaluate expression ESCC from normal, premalignant, and malignant lesions, clarify mechanisms by which contributes progression ESCC. Experimental Design Two hundred fourteen paired specimens, an independent set 28 patients, were used analyze correlation between pathological characteristics tumors using immunohistochemistry....
Using low-coverage whole genome sequencing technique to analyze the chromosomal copy number alterations in exfoliative cells of cervical cancer ABSTRACTObjectives: We analyzed chromosomal-arm-level (CNAs) cell and tissue samples by using genomic technique.Methods: In this study, we retrospectively collected 55 archived exfoliated suspension corresponding formalin-fixed paraffin-embedded section including 27 invasive 28 control cases.We also 19 randomly from women verify new algorithm...
The miRNA had been brand-new hot spot for study on pathogenesis of malignant tumor and seeking prevention strategy. occurrence development could be regulated by Gli1/Snail signaling pathway through Hedgehog channel. Our intends to discuss the role derived from BMSC in HPV. miR-134 was analyzed nano-particles observed under fluorescence microscope along with analysis expression RTPCR. HPV rat model established analyze miR-134’s metastasis vivo . level staging N2–N3 lower than that N0–N1...