Objective To evaluate the possible association of cytokine polymorphisms with risk nasopharyngeal carcinoma (NPC). Methods We performed a comprehensive search electronic databases from PubMed, Web Science, Embase, and CNKI. Articles related to in patients NPC healthy controls inception 1 April 2024 were included. The results analysed independently by two reviewers using RevMan 5.4 software. Summary odds ratio (OR) 95% confidence interval (CI) used cancer risk. Results Our showed that IL-10...

The transition of macrophages from the proinflammatory M1 to anti-inflammatory M2 phenotype is crucial during wound healing process. In this study, we assess role chemokine (C-C motif) ligand 6 (CCL6) in modulating macrophage polarization and healing. Initially, observed significantly upregulated CCL6 expression skin tissue on edge inflammation proliferation phases. Furthermore, discovered that mice treated with rCCL6 had accelerated increased levels M2-type macrophages. Using vitro models,...

Keratinocyte proliferation and migration are crucial steps during skin wound healing. The functional role of microRNAs (miRs) remains relatively unknown this process. miR-93 levels have been reported to increase within 24 h healing; however, whether miR-93-3p or miR-93-5p plays a specific in healing is yet be studied. In study, with the use an vivo mouse wound-healing model, we demonstrate that significantly upregulated, whereas there no change expression HaCaT cells, overexpression...

Abstract Background TGF-β1 promotes keratinocyte migration and re-epithelialization of cutaneous wounds during the wound healing process. Decreased SOCS7 expression has been associated with increased potential. However, relationship between in remains unclear. Objectives To investigate keratinocytes skin healing. Methods The under different concentrations was detected by WB qPCR. ability scratch Transwell assay. Protein interactions were ChIP luciferase effect on mice animal model. Results...

The reconstruction of large full-thickness scalp defects remains a surgical challenge, especially when the skull is exposed completely without periosteum. Surgical technique options for wound coverage have included tissue expansion, skin grafting, local or regional flaps, and microvascular free transfer. In recent years, some authors reported to use biological material as an alternative repairing complex wounds. report successful defect with bare in bilateral temporal regions 3-year-old...

Proliferation and migration of keratinocytes are vital processes for the successful epithelization specifically after wounding. MiR-221 has been identified to play a potential role in promoting wound regeneration by inducing blood vessel formation. However, little is known about miR-221 keratinocyte proliferation during healing. An vivo mice wound-healing model was generated; expression levels were assessed qRT-PCR fluorescence situ hybridization. Initially, we found that upregulated...

Abstract Background: The purpose of this study is to analyze the registered clinical trials COVID-19, and provide a reference for treatment COVID-19. Methods: Chinese ClinicalTrial Registry (ChiCTR) Clinicaltrials.gov databases were searched which from inception February 29, 2020, screen out on research units regions, sample size, types, stages, intervention measures analyzed. Results: There 226 COVID-19 in 2 databases, all them by China. top five areas Hubei, Beijing, Shanghai, Guangdong,...

The primary presumed advantages of the deep inferior epigastric perforator flap over other muscle-sparing (MS) transverse rectus abdominis myocutaneous flaps are improved functional muscle outcomes and decreased abdominal contour morbidities. purpose this study was to verify viewpoint objectively quantitatively using an animal model.Six rats were used in pilot 40 equally divided into a control group 4 experimental groups (MS0, MS1, MS2, MS3) according amount muscles harvested. At 3 6 weeks,...

Abstract Peanut skin (PS) contains various flavonoids and phenols that have antitumor antioxidant effects. However, no research has been conducted on PS hepatocellular carcinoma (HCC). Therefore, this study sought to explore the potential mechanism of in treating HCC. was searched for Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform SYMMAP databases. HCC targets were five major Protein‐protein interaction network, Gene Ontology, Kyoto Encyclopedia Genes Genomes...

Objective To search for a treatment approach scalp avulsion injury based on the clinical experiences and review of literature. Methods Twenty-six consecutive cases were involved in study: 15 complete (5 including forehead skin) 11 partial avulsion. Cranial bones exposure occurred 16 cases, which had size over 4×4 cm2. The methods various: with microsurgical replantation, 9 skin grafting, 4 secondary grafting followed by multiple drilling calvarium, 1 case local flap, free flap....

Objective: There are many clinical trials on the treatment of Coronavirus Disease 2019 (COVID-19), however, there is a lack systematic understanding COVID-19. The purpose this study to analyze registration COVID-19, and provide reference for treatment. Methods: Chinese ClinicalTrial Registry (ChiCTR) clinicaltrial.gov were searched Clinical which registered from inception February 29, 2020, screen out research units regions, sample size, types, stages intervention measures analyzed. Results:...