A5100780443- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Bioactive natural compounds
- Plant-based Medicinal Research
- Psoriasis: Treatment and Pathogenesis
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Flavonoids in Medical Research
- Genetics, Aging, and Longevity in Model Organisms
- Morinda citrifolia extract uses
- Medicinal Plant Pharmacodynamics Research
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Advanced Glycation End Products research
- Autoimmune and Inflammatory Disorders Research
- Angiogenesis and VEGF in Cancer
- Alcohol Consumption and Health Effects
- PI3K/AKT/mTOR signaling in cancer
Hangzhou First People's Hospital
2024
Westlake University
2024
Beijing University of Technology
2024
Beijing Radiation Center
2024
Chengdu University of Traditional Chinese Medicine
2023
China Pharmaceutical University
2019-2021
Southeast University
2021
State Key Laboratory of Natural Medicine
2019-2020
Harbin Medical University
2020
Fourth Affiliated Hospital of Harbin Medical University
2020
Macrophages have an affinity to developing tumors and been shown play a role in tumor combat immune surveillance. However, the exact mechanism by which macrophages participate anti-tumor response remains unclear. Hence, current study aimed identify effect of on gastric cancer (GC) cells via exosomes. Paired cancerous, tumor-adjacent, non-cancerous stomach tissues were initially from 68 GC patients. T isolated peripheral blood mononuclear (PBMCs) obtained both patients as well healthy donors....
Metastasis is the leading cause of death in patients with breast cancer and aberrantly expressed microRNAs (miRNAs) are highly associated this process. A previous study has shown that miR-335 downregulated can suppress tumor invasion metastasis. Emerging evidences indicate c-Met implicated cell scattering, migration, invasion. However, little known about relationship between expression alteration cancer. In present study, we found was protein upregulated two human lines. MiR-335 to...
Bufalin can induce apoptosis in certain human cancer cell lines, but bufalin has not yet been thoroughly evaluated colorectal cells. Cleavage and polyadenylation specific factor 4 (CPSF4) telomerase reverse transcriptase (hTERT) play important roles growth. The aim of this study was to investigate the interactions bufalin, CPSF4 hTERT effects cancer.We treated LoVo SW620 cells with effect on proliferation, migration. We verified relationship between using pulldown assays, luciferase reporter...
High‑altitude acute hypoxia is commonly associated with respiratory cardiovascular diseases. The inability to adapt may lead dysfunction, lung injury and even death. Therefore, understanding the molecular basis of adaptation high‑altitude reveal novel therapeutic approaches which counteract detrimental consequences hypoxia. In present study, a environment was simulated in rat model order investigate role high mobility group protein‑1 (HMGB1)/receptor for advanced glycation end products...
Objective Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies and fifth common in women. Circular RNAs (circRNAs) have been shown to play vital functions cancers, but few studies focused on mechanism dysregulated circRNAs PTC. Methods Quantitative reverse transcription PCR was used measure circ-NCOR2 levels PTC tissues cell lines. The were examined by analysis using counting kit-8, clone forming, flow cytometry, Transwell experiments. Bioinformatic dual...
The relationship between liver enzymes and clustered components of metabolic syndrome (MetS) is explored the predictive power γ-glutamyl transferase (GGT) for diagnosis MetS in an adult population Beijing investigated. A total 10,553 adults aged 20–65 years who underwent health examinations at Tongren Hospital 2012 were enrolled study. Multivariate logistic regression analysis conducted to determine associations levels various MetS. receiver operating characteristic used optimal cut-off...
Compelling evidence has demonstrated that Th17 cells play an essential role in the pathogenesis of multiple sclerosis (MS). Long noncoding RNAs (lncRNAs) have been confirmed as vital regulators immune cell differentiation and other functions. However, whether how lncRNAs influence functional behaviors remain largely unclear. Here, we identified a lncRNA, namely Gm15575, is specifically enriched spleen tissues EAE mice. Functionally, knockdown Gm15575 suppressed secretion IL17A....
Vaccine effectiveness is mainly determined by the mechanism mediating protection, emphasizing importance of unraveling protective for novel pneumococcal vaccine development. We previously demonstrated that regulatory T (Treg) cell immune response has a effect against infection elicited live attenuated SPY1. However, underlying this remains unclear. In study, short synthetic peptide (P17) was used to down-regulate Treg cells during immunization and subsequent challenges in mouse model....
Interleukin (IL)-23 is considered an effective therapeutic target for the treatment of psoriasis because crucial role IL-23/IL-17 axis in pathogenesis psoriasis, and it has recently been reported to be involved ILC3 cell differentiation. In this study, we report that eukaryotically expressed rhIL23R-CHR/Fc, as endogenous extracellular receptor analogue, could a natural antagonist imiquimod (IMQ)-induced psoriasis-like mouse model, including antagonizing effect suppressed inflammation skin...
Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly caused by excessive accumulation of autoantibodies target such as nucleic acids. T helper (Th) cell have been associated with the development SLE. Typically, different subsets Th cells secrete various cytokines to regulate progression. IL-12 and IL-23 participate in differentiation activation multiple subsets, including Th1, Th2, Th9, Th17, regulatory (Treg) follicular (Tfh) cells. Because signature p40 subunit shared...
Background: Arm protein lost in epithelial cancers, on chromosome X (ALEX) is a novel subgroup within the armadillo (ARM) family, which has one or two ARM repeat domains as opposed to more than six-thirteen repeats classical Armadillo family members. Materials and Methods: In study, we explore biological functions of ALEX1 breast cancer cells. Overexpression silencing were performed with SK-BR3 MCF-7 cell lines. Cell proliferation colony formation assays, along flow cytometry, carried out...
Abstract Background Enterovirus 71 (EV71) infection contributes to hand, foot, and mouth disease (HFMD) with severe neurogenic complications, leading higher morbidity. In addition their typical roles in coagulation, platelets could serve as essential immune regulatory cells play a key role the pathogenesis of this viral infection. Methods Platelet parameters were measured using an automatic hematology analyzer. T-helper type 1 (Th1) Th2 analyzed by flow cytometry. The levels cytokines...
Budd-Chiari syndrome (BCS) is a life-threatening hepatic disease characterized by venous obstruction at the level of vein, venules, or inferior vena cava. No evidence reported relationship between endothelial progenitor cells and deficiency factor V Leiden protein C in patients with primary syndrome.We recruited participants June 2014 July 2015. For BCS group, 28 were collected. 20 included NAFLD group. Another 73 healthy into control None had received interventional therapy undergone...