A5004666755- Chronic Kidney Disease and Diabetes
- Vitamin D Research Studies
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Glutathione Transferases and Polymorphisms
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Acute Kidney Injury Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Free Radicals and Antioxidants
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- RNA modifications and cancer
- Bone health and osteoporosis research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Diet and metabolism studies
- Trace Elements in Health
- Gout, Hyperuricemia, Uric Acid
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
Mianyang Central Hospital
2016-2025
Southwest University of Science and Technology
2025
University of Electronic Science and Technology of China
2012-2024
Southwest Medical University
2017-2023
Beijing Sanbo Brain Hospital
2023
Capital Medical University
2023
Chengdu University of Traditional Chinese Medicine
2022
Affiliated Hospital of Southwest Medical University
2020-2021
Leshan Normal University
2011-2020
Dalian Medical University
2010
Uranium-induced kidney damage represents a major health concern due to its toxic effects, including mitochondrial dysfunction and inflammation. Mitochondrial DNA (mtDNA)-mediated pyroptosis is critical pathway in the pathogenesis of renal injury. The toll-like receptor 4 / nuclear factor-kappa B (TLR4/NF-κB) signaling plays pivotal role this process. Recent studies have shown that extracellular vesicles derived from adipose-derived stem cells (ADSCs-EVs) possess therapeutic potential their...
Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order evaluate total oxidant/antioxidant status patients with thyroid cancer and investigate relationship between oxidative parameters serum profiles among various controls, we determined including antioxidant (TAS) oxidant (TOS) calculation index (OSI) sera 82 patients, 56 benign disease 50 healthy controls. It was found that TAS levels were significantly lower than controls (P<0.001), while TOS OSI...
Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative biomarkers and status development colorectal cancer (CRC) are scarce; previous have failed to establish serum total oxidant/antioxidant CRC. Therefore, we compared levels CRC patients healthy subjects, analyzed their clinical significance Fasting blood samples from 132 64 subjects were collected. parameters, including oxidant (TOS) antioxidant (TAS), measured, index...
Gastric cancer is a common tumor of the digestive system. Identification potential molecules associated with gastric progression and validation biomarkers for diagnosis are very important. Thus, aim our study was to determine serum metabolic characteristics patients chronic gastritis (CG) or (GC) validate candidate disease diagnosis.A total 123 human samples from CG GC were collected untargeted metabolomic analysis via UHPLC-Q-TOF/MS serum. Principal component (PCA), partial least squares...
A high-performance liquid chromatography coupled with a diode array detector and electrospray ionization mass spectrometry method was developed for the simultaneous analysis of fourteen characteristic components in roots three related polygonaceous medicinal plants.
Many studies have identified causal and promotive roles of oxidative stress (OxS) damage caused by OxS in the occurrence progression cancer. biomarkers blood circulation patients may change correspondingly with development tumors. This study is aimed at investigating correlation between serum trace element (TE) levels different types cancer.1143 cancer 178 healthy controls from Mar. 2018 to Aug. 2020 Mianyang Central Hospital were involved this study. Their parameters (including total...
To establish equations for the estimation of glomerular filtration rates (eGFRs) based on serum creatinine (SCr) and/or cystatin C (SCysC) in Chinese patients with chronic kidney disease (CKD), and to compare new both reference GFR (rGFR) literature evaluate their applicability.The 788 CKD were randomly divided into two groups, training group testing group, eGFR-formulas CysC validate established formulas, respectively. (99m)Tc-DTPA clearance (as rGFR), Cr, determined all patients, was...
Objective: Diabetic kidney disease (DKD) leads to low high albuminuria and gradually progresses very with insufficiency. However, about 20% -40% of DKD is normoalbuminuric (NADKD), which has impaired function, but normal urine albumin. This study investigate the metabolomic profiles patients NADKD (ADKD). Methods: Totally, 95 were divided into simple diabetes mellitus group (SDM group), ADKD group. All subjects analyzed for metabolites using non-targeted metabolomics based on Ultra...
Rhizoma Chuanxiong (RC) is the dried rhizome of Ligusticum chuanxiong Hort., and various types processed (PRC) are widely used in China. However, quality assurance control these medicines remain challenging. This study aims to investigate chemical compositions PRC preparations by a high-performance liquid chromatography (HPLC) coupled with diode array detection (DAD) method.A HPLC-DAD method validation was developed for samples. Seven batches plant samples from two processing methods,...
Until now, the metabolic effects of hepatitis B virus (HBV) replication on progression hepatic diseases (hepatitis, cirrhosis, and liver cancer) functions have remained unexplored. Thus, a total 199 disease patients with active inactive HBV were enrolled in this study to explore serum characteristics using untargeted metabolomics. Multiple analyses, including principal component analysis (PCA), partial least squares discriminant (PLS-DA), volcano plot pathway analysis, used for data...
Prostate cancer (PCa) is the second most common male malignancy globally. Prostate-specific antigen (PSA) an important biomarker for PCa diagnosis. However, it not accurate in diagnostic gray zone of 4-10 ng/ml PSA. In current study, performance serum metabolomics profiling discriminating patients from benign prostatic hyperplasia (BPH) individuals with a PSA concentration range was explored.A total 220 individuals, including diagnosed and BPH within levels healthy controls, were enrolled...
Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines-particularly medicines-work. In many cases, active components are generated metabolic activation. This critical for drug research development. As a means explore therapeutic mechanism Dioscorea nipponica (DN), medicinal plant used treat myocardial ischemia (MI), metabolites from DN were identified, cardioprotective efficacy these was evaluated. Our...
Background/Aims: MicroRNAs (miRNAs) play a crucial role in erythropoiesis. MiR-23a∼27a∼24-2 clusters have been proven to take part erythropoiesis via some proteins. CDC25B (cell division control Cdc2 phosphostase B) is also the target of mir-27a; whether it regulates and its mechanism are unknown. Methods: To evaluate potential miR-27a during erythroid differentiation, we performed gain- loss-of-function experiments on hemin-induced K562 cells. We detected expression after hemin stimulation...
Abstract Renal cell carcinoma (RCC) is a common urologic malignancy, and up to 30% of RCC patients present with locally advanced or metastatic disease at the time initial diagnosis. Increasing evidence suggests that circular RNAs (circRNAs) serve as genomic regulatory molecules in various human cancers. Our silico microarray‐based analysis identified circRNA circ_001842 was highly expressed RCC. Such up‐regulation experimentally validated tissues lines using RT‐qPCR. Thereafter, we attempted...
Abstract Background Increasing evidence highlights the potential role of long non-coding RNAs (lncRNAs) in biological behaviors renal cell carcinoma (RCC). Here, we explored mechanism AGAP2-AS1 occurrence and development clear RCC (ccRCC) involving IGF2BP3/miR-9-5p/THBS2. Methods The expressions AGAP2-AS1, IGF2BP3, miR-9-5p, THBS2 their relationship were analyzed by bioinformatics. targeting between miR-9-5p was evaluated with effect on macrophage polarization assayed. Finally, tested ccRCC...
Abstract Background Renal cell carcinoma (RCC) is a common urological cancer. circular RNAs (circRNAs) involved in the development of various types cancers. However, roles and underlying mechanisms circRNAs RCC are not fully elucidated. Herein, we aimed to examine potential effect circ_001287 on progression. Materials Methods Microarray-based gene expression profiling was initially employed order identify differentially expressed genes. Next, examined, line with highest selected for...
Acute kidney injury (AKI) is one of the most common clinical emergencies characterized by rapid progression, difficulty in early diagnosis, and high mortality. Currently, there are no effective AKI diagnostic methods treatments. Therefore, identifying new mechanisms have become urgent for development targets diagnosis treatment current setting.In this study, systematic analysis comparison serum metabolic profiles patients, chronic disease (CKD) healthy subjects were performed using...