A5100384944- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- RNA Research and Splicing
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Heat shock proteins research
- Morinda citrifolia extract uses
- Multicomponent Synthesis of Heterocycles
Lanzhou University
2013-2024
Nantong University
2024
First Hospital of Lanzhou University
2013-2024
Jilin Agricultural University
2022-2024
Taizhou People's Hospital
2024
Southern Medical University
2023
Maternal and Child Health Hospital of Sichuan Province
2023
Tianjin Medical University Cancer Institute and Hospital
2014-2022
Lishui City People's Hospital
2022
Helmholtz Zentrum München
2022
Abstract Purpose: Current systems of gastric cancer molecular classification include genomic, molecular, and morphological features. Gastric based on tissue metabolomics remains lacking. This study aimed to define metabolically distinct subtypes identify their clinicopathological characteristics. Experimental Design: Spatial by high mass resolution imaging spectrometry was performed in 362 patients with cancer. K−means clustering used tumor stroma-related metabolites. The identified were...
Cadmium (Cd) is a common environmental heavy metal contaminant of reproduction toxicity. Cd accumulation in animals leads to the damage granulosa cells. However, its mechanism needs be elucidated. This research found that treating cells with resulted reduced cell viability. The flow cytometry results showed increased degree apoptosis and level superoxide anion (O2−) Further analysis treatment expression levels nuclear factor erythroid 2-related factor-2 (Nrf2), dismutase (SOD), catalase...
ABSTRACT N6-methyladenosine (m6A), as a eukaryotic mRNA modification catalyzed by methyltransferase METTL3, is involved in various processes of development or diseases via regulating RNA metabolism. However, the effect METTL3-mediated m6A tooth has remained elusive. Here we show that METTL3 prevalently expressed odontoblasts, dental pulp cells, follicle and epithelial cells Hertwig's root sheath during formation. Depletion human (hDPCs) impairs proliferation, migration, odontogenic...
Latent transforming growth factor-β-binding protein (LTBP)2 is a member of the fibrillin/LTBP superfamily extracellular matrix proteins, and has been demonstrated to exhibit tumor-promoting tumor-suppressive functions in different types cancer. However, function LTBP2 gastric cancer (GC) remains unknown. The aim present study was investigate expression molecular GC, evaluate its prognostic value for patients with GC. results revealed that upregulated GC tissues cell lines. Increased...
Abstract We report a 49-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy trastuzumab-containing regimen. He underwent esophagogastroduodenoscopy in September 2009, which revealed 2-cm ulcer on the lesser curvature proximal to angularis. Biopsy of showed moderately differentiated overexpression human epidermal growth factor receptor 2 (HER2) by immunohistochemistry and fluorescence situ hybridization....
Abstract Background Increasing evidence highlights the potential role of long non-coding RNAs (lncRNAs) in biological behaviors renal cell carcinoma (RCC). Here, we explored mechanism AGAP2-AS1 occurrence and development clear RCC (ccRCC) involving IGF2BP3/miR-9-5p/THBS2. Methods The expressions AGAP2-AS1, IGF2BP3, miR-9-5p, THBS2 their relationship were analyzed by bioinformatics. targeting between miR-9-5p was evaluated with effect on macrophage polarization assayed. Finally, tested ccRCC...
Lymph node metastasis (LNM) is an important factor for both treatment and prognosis of early gastric cancer (EGC). Current methods are insufficient to evaluate LNM in EGC due suboptimal accuracy. Herein, we aim identify methylation signatures EGC, facilitate precision diagnosis, guide modalities.For marker discovery, genome-wide sequencing was performed a cohort (marker discovery) using 47 fresh frozen (FF) tissue samples. The identified were subsequently characterized model development...
Gastric cancer ranks high in terms of morbidity and mortality worldwide. Multimodal therapy is therefore essential for locally advanced gastric cancer. Recent studies have demonstrated that both perioperative chemotherapy neoadjuvant chemoradiotherapy can improve the prognosis patients. However, completion rate after surgery remains low, which may affect survival. Thus, identifying best way to combine radiotherapy, important. The aim this study was explore toxicity efficacy total modality...
Abstract Background The existing ex vivo models of endoscopic submucosal dissection (ESD) cannot simulate intraoperative hemorrhage well. We aimed to establish an ESD training method by applying model with continuous perfusion (ETM-CP). Methods Four sessions were conducted for 25 novices under the guidance 2 experts. Eventually, 10 completed operations on a total 89 patients after training. resection effectiveness, speed, complication rate, and novice performance before compared. data...
Gastric cancer (GC) often develops resistance to cisplatin treatment, but while latent transforming growth factor β-binding protein (LTBP2) is recognized as a potential regulator in GC, its specific role not fully understood. This study investigated LTBP2's impact on GC. LTBP2 expression was assessed various GC cell lines, and correlation with sensitivity determined through viability assays. Lentivirus-mediated silencing HGC-27 cells demonstrated enhanced sensitivity, reduced proliferation,...
Erlotinib is a novel therapeutic agent for cancer treatment. This study was performed to investigate the role of c-MET-PI3K-AKT pathway in regulation erlotinib-induced radiosensitization.A973 lung adenocarcinoma cells treated with 6 Gy radiation were incubated presence erlotinib. The apoptotic rate after 24 hours, colony-formating 14 days, and changes c-MET expression levels days irradiation examined. Surviving fractions different treatment groups (blank control, alone, erlotinib anti-c-MET...
A lack of research on the association trefoil factors (TFF) with gastric cancer and premalignant lesions (PML) in general population is an important obstacle to application TFFs for screening. We aimed analyze PMLs a population.We evaluated 3,986 adults residing Wuwei, China. collected baseline characteristics risk factors, including TFFs, endoscopic diagnosis, pathologic information. Three logistic regression models were generated between cancer, as well PMLs. Adjusted odds ratio (OR) 95%...
Abstract Background Endoscopic submucosal dissection (ESD) is gaining enormous popularity in the treatment of early gastric cancers (EGCs) many institutions across world. However, appropriate selection candidates for endoscopic resection crucial to sufficiently mitigate non-e-curative (NEC) resection. This study aims at identifying various clinico-pathologic factors that independently predict NEC outcome and depth invasion following ESD procedure patients with EGC. Methods Multiple logistic...
BACKGROUNDIt remains controversial as to which pathological classification is most valuable in predicting the overall survival (OS) of patients with gastric cancer (GC). AIMTo assess prognostic performances three classifications GC