A5101507986- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- RNA Research and Splicing
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Traditional Chinese Medicine Studies
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Cancer Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Sepsis Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- Barrier Structure and Function Studies
- Adenosine and Purinergic Signaling
- Metallic Glasses and Amorphous Alloys
- Gastrointestinal Bleeding Diagnosis and Treatment
- Sulfur Compounds in Biology
Huazhong University of Science and Technology
2022-2024
Union Hospital
2022-2024
Weifang People's Hospital
2024
Lanzhou University
2014-2023
First Hospital of Lanzhou University
2020-2023
Gansu Provincial Hospital
2023
Weifang University
2023
Shandong University
2023
First Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Tyrosine kinase inhibitors (TKIs) are mostly used in non-small cell lung cancer (NSCLC) treatment. Unfortunately, treatment with Gefitinib for a period of time will result drug resistance and cause failure clinic. Therefore, exploring novel compounds to overcome this is urgently required. Here we investigated the antitumor effect homoharringtonine (HHT), natural compound extracted from Cephalotaxus harringtonia, on Gefitinib-resistant NSCLC lines vitro vivo. NCI-H1975 cells EGFR T790M...
Gastric cancer, one of the most common malignancies worldwide, typically has a poor prognosis and survival rate. Previous studies have investigated chemopreventive effect celecoxib. In present study, SGC-7901 human gastric cancer cell line was utilized to examine mechanisms The inhibition proliferation determined using MTT assay, apoptosis monitored by terminal deoxynucleotidyl transferase-mediated dUTP nick end‑labeling (TUNEL) flow cytometry, ultrastructural changes were assessed via...
Fospropofol disodium is comparable to propofol in maintaining mild-to-moderate sedation for mechanically ventilated patients intensive care unit (ICU). However, its efficacy deep remains unclear. Therefore, we conducted a randomized-controlled trial comparing the and safety of fospropofol with ICU. In this randomized pilot study, critically ill adult requiring were receive or propofol. The study drug was titrated maintain Richmond Agitation-Sedation Scale score (RASS) of-5 or-4. Narcotrend...
Cytokine release syndrome (CRS) remains to be a major adverse effect of chimeric antigen receptor T (CAR-T) cell therapy in B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. It was urgent explore novel strategy for managing severe CRS. We conducted clinical trial assess the safety efficacy CD19-targeting CAR-T-cells treatment relapsed chemotherapy-refractory B-ALL A 10-year-old boy with who never achieved minimal residual disease (MRD) negative status after 5 courses chemotherapy...
To evaluate the prevalence of Helicobacter pylori infection and risk factors to serotype strains in Wuwei, located north-western China, which has a high incidence gastric cancer. was analysed 21 291 adults by 14 C-urea breath test, H. antibody were detected 9183 serum samples latex immunoturbidimetric method. The correlation with demographic-economic, lifestyle medical history among participants determined questionnaire. antibodies against urease, VacA CagA dot immunobinding assay. rate...
Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where control group was usually a healthy population. However, it is unclear at what stage known factor exert their influence toward progression to cancer. Based on Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 atrophic (CAG), 1,757 intestinal metaplasia (IM), 2,239 low-grade dysplasia (LGD), and 182 high-grade (HGD) or GAC assess between each two...
Community-acquired pneumonia (CAP) is an extraordinarily heterogeneous illness, both in the range of responsible pathogens and host response. Metagenomic next-generation sequencing (mNGS) a promising technology for pathogen detection. However, clinical application mNGS detection remains challenging.A total 205 patients with CAP admitted to intensive care unit were recruited, broncho alveolar lavage fluids (BALFs) from 83 patients, sputum samples 33 cases, blood 89 cases collected by mNGS. At...
Our study aimed to investigate the effects of different extracorporeal membrane oxygenation (ECMO) blood flow rates on lung perfusion assessment using saline bolus-based electrical impedance tomography (EIT) technique in patients veno-venous (VV) ECMO.
Colorectal cancer (CRC) is one of the most prevalent and fatal malignancies, novel biomarkers for diagnosis prognosis CRC must be identified. RNA-binding proteins (RBPs) are essential modulators transcription translation. They frequently dysregulated in various cancers related to tumorigenesis development. The mechanisms by which RBPs regulate progression poorly understood no clinical prognostic model using has been reported CRC. We sought identify hub prognosis-related construct a use. mRNA...
The aim of this study was to investigate the physiological impact airway pressure release ventilation (APRV) on patients with early moderate-to-severe acute respiratory distress syndrome (ARDS) by electrical impedance tomography (EIT).In single-center prospective study, adult ARDS mechanically ventilated APRV were assessed EIT shortly after (T0), and 6 h (T1), 12 (T2), 24 (T3) initiation. Regional perfusion distribution, dead space (%), shunt ventilation/perfusion matching (%) based...
Background and Aim : Gastric cancer (GC) is the common leading cause of cancer‐related death worldwide. Immune‐related genes (IRGs) may potentially predict lymph node metastasis (LNM). We aimed to develop a preoperative model LNM based on these IRGs. Methods In this paper, we compared evaluated three machine learning models publicly available gene expression data from TCGA‐STAD. The Pearson correlation coefficient (PCC) method was utilized feature selection according its relationships with...
A lack of research on the association trefoil factors (TFF) with gastric cancer and premalignant lesions (PML) in general population is an important obstacle to application TFFs for screening. We aimed analyze PMLs a population.We evaluated 3,986 adults residing Wuwei, China. collected baseline characteristics risk factors, including TFFs, endoscopic diagnosis, pathologic information. Three logistic regression models were generated between cancer, as well PMLs. Adjusted odds ratio (OR) 95%...
This study intends to investigate the correlation between blood pressure variability (BPV) levels and use of optical coherence tomography (OCT) angiography (OCTA) measure retinal microvasculature in hypertensive patients.All individuals had 24-hour ambulatory monitoring bilateral OCT OCTA exams, only data from right eye were analyzed statistically.The included 170 individuals, with 60 control group. The experimental group was separated into two groups based on average real (ARV) median, 55...
The epidemiology of fungi identified via next-generation sequencing in bronchoalveolar lavage fluid among patients with COVID-19 is unknown.
BackgroundAcute myeloid leukemia (AML) is a malignant clonal proliferative disease of hematopoietic system. Despite tremendous progress in uncovering the AML genome, only small number mutations have been incorporated into risk stratification and used as therapeutic targets. In this research, we performed to construct predictive prognosis model for patients according gene mutations.MethodsNext-generation sequencing (NGS) technology was utilized detect mutation from 118 patients. mRNA...
In this study, we aimed to evaluate the diagnostic values of alpha-fetoprotein (AFP), soluble AXL (sAXL), des-γ-carboxy prothrombin (DCP), aspartate aminotransferase-to-platelet ratio index (APRI), and gamma-glutamyl transpeptidase-to-platelet (GPR) in hepatocellular carcinoma (HCC) possible underlying mechanisms correlations between them.We collected serum samples from 190, 128, 75 patients with HCC, cirrhosis, chronic viral hepatitis, 82 healthy subjects. Serum levels AFP, sAXL, DCP were...