A5100328569- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Voice and Speech Disorders
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Surface Chemistry and Catalysis
- Peptidase Inhibition and Analysis
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Tea Polyphenols and Effects
- Digital Imaging for Blood Diseases
- Pancreatic and Hepatic Oncology Research
- Digital Communication and Language
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Music Perception
- Cancer-related gene regulation
- Multisensory perception and integration
- Image Retrieval and Classification Techniques
- Glaucoma and retinal disorders
- Topic Modeling
- CAR-T cell therapy research
- Intraocular Surgery and Lenses
- Autophagy in Disease and Therapy
University of Science and Technology of China
2021-2025
Sun Yat-sen University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
China Medical University
2024
Fourth Affiliated Hospital of China Medical University
2024
Sichuan Animal Science Academy
2024
Zhongnan University of Economics and Law
2024
Northeastern University
2024
Abstract Due to the uncertainty of weather conditions and nonlinearity high-dimensional data, as well need for a continuous stable power supply system, traditional regression analysis time series forecasting methods are no longer able meet high accuracy requirements today's PV forecasting. To significantly improve prediction short-term output power, this paper proposes method based on hybrid model temporal convolutional networks gated recurrent units with an efficient channel attention...
Neuroprotective effects of tea polyphenols on apoptosis and oxidative stress induced by constant darkness H<sub>2</sub>O<sub>2</sub><italic>in vivo</italic>and<italic>in vitro</italic>.
As a major nutraceutical component of green tea (−)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists due to its well-documented antioxidant and antiobesity bioactivities.
Due to lack of annotated pathological images, transfer learning has been the predominant approach in field digital pathology. Pre-trained neural networks based on ImageNet database are often used extract “off-the-shelf” features, achieving great success predicting tissue types, molecular and clinical outcomes, etc. We hypothesize that fine-tuning pre-trained models using histopathological images could further improve feature extraction, downstream prediction performance. 100 000 H&E image...
Background Previous studies indicate that exogenous use of glucocorticoid (GC) affects immune checkpoint inhibitor (ICI) efficacy. However, there is a paucity clinical data evaluating the direct impact endogenous GC on efficacy for cancer patients with blockade. Methods We first compared circulating levels in healthy individuals and cancer. next retrospectively reviewed advanced PD-1/PD-L1 alone or combination therapy single center. The effects baseline objective response rate (ORR), durable...
Abstract Many artificial intelligence models have been developed to predict clinically relevant biomarkers for colorectal cancer (CRC), including microsatellite instability (MSI). However, existing deep learning networks require large training datasets, which are often hard obtain. In this study, based on the latest Hierarchical Vision Transformer using Shifted Windows (Swin [Swin‐T]), we an efficient workflow in CRC (MSI, hypermutation, chromosomal instability, CpG island methylator...
A disintegrin and metalloprotease 10 ( ADAM 10) is a typical member of the s family, which has been reported to be upregulated in various types cancers contribute cancer progression metastasis. However, little known about role nasopharyngeal carcinoma NPC ). The purpose this study explore expression status its biological functions . We first examined tissues cell lines by immunohistochemistry, Western blotting, PCR , immunofluorescence analysis. observed that was significantly elevated level...
Abstract Deep learning models are increasingly being used to interpret whole‐slide images (WSIs) in digital pathology and predict genetic mutations. Currently, it is commonly assumed that tumor regions have most of the predictive power. However, reasonable assume other tissues from microenvironment may also provide important information. In this paper, we propose an unsupervised clustering‐based multiple‐instance deep model for prediction mutations using WSIs three cancer types obtained The...
Immunotherapy with programmed death 1 (PD-1) inhibitor has shown activity as first- or second-line treatment for various metastatic human malignancies. Immune-related adverse events (irAEs) are now well-described, and most organ sites potentially influenced, but the prevalence of myocarditis myositis/myasthenia gravis (MG) overlap syndrome following esophageal hiatal hernia induced by immunotherapy is rarely reported. Here, we describe a 71-year-old woman progressed unresectable extrahepatic...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy in the past decade and amplify T-cell-mediated immune responses by disrupting immunoinhibitory signals. The augmented T-cell response has led to a range of immune-related adverse effects (irAEs). Immune-related cardiotoxicity been reported case series but underappreciated due difficulties diagnosis. This article describes epidemiological, clinical presentation, subtype, treatment data new systematic framework for...
Rabbit hemorrhagic disease (RHD) is an acute fatal caused by the rabbit virus (RHDV). Since first outbreaks of type 2 RHDV (RHDV2) in April 2020 China, persistence this population has substantial economic losses husbandry. Previous failures preventing RHDV2 prompted us to further investigate immune mechanisms underlying virus’s pathogenicity, particularly concerning spleen, a vital component mononuclear phagocyte system (MPS). For this, previous isolate, CHN/SC2020, was utilized challenge...
Abstract Background Immune checkpoint inhibitors (ICIs) can improve survivals of metastatic triple negative breast cancer (mTNBC); however, we still seek circulating blood biomarkers to predict the efficacy ICIs. Materials and methods In this study, analyzed data ICIs treated mTNBC collected in Anhui Medical University affiliated hospitals from 2018 2023. The counts lymphocytes, monocytes, platelets, ratio indexes (NLR, MLR, PLR) peripheral were investigated via Kaplan-Meier curves Cox...
Pancreatic ductal adenocarcinoma is a common malignant tumor with poor prognosis. Autophagy activity changes in both cancer cells and microenvironment affects the progression of pancreatic adenocarcinoma. The purpose this study was to predict prognostic autophagy regulatory genes their role regulation We draw conclusions based on gene expression data from different platforms: GSE62165 GSE85916 array platform, TCGA bulk RNA-seq GSE111672 single-cell platform. At first, we detected...