A5102854890- Service-Oriented Architecture and Web Services
- Alcohol Consumption and Health Effects
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Enzyme Catalysis and Immobilization
- Liver physiology and pathology
- Advanced Software Engineering Methodologies
- Lung Cancer Research Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Business Process Modeling and Analysis
- Malaria Research and Control
- Dental materials and restorations
- Endoplasmic Reticulum Stress and Disease
- Semantic Web and Ontologies
- Light effects on plants
- Drug Transport and Resistance Mechanisms
- Biochemical and Molecular Research
- Nuclear Receptors and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Axial and Atropisomeric Chirality Synthesis
- COVID-19 and healthcare impacts
- Dental Radiography and Imaging
- Advanced Computational Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
First Affiliated Hospital of Anhui Medical University
2022-2025
Anhui Medical University
2022-2025
Shanghai Jiao Tong University
2004-2025
Shanghai Ninth People's Hospital
2022-2024
First Affiliated Hospital of Chengdu Medical College
2023
Shandong University
2022
Jiangnan University
2019-2020
University of Mannheim
2009
Peking University
2007
Abstract Osteoarthritis (OA) is a prevalent joint disease with no effective treatment strategies. Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis. Although multiple studies have detected potential regulatory mechanisms underlying and concentrated on developing novel strategies, the epigenetic control of remains unclear. Histone demethylase JMJD3 has been reported mediate physiological pathological processes, including cell differentiation,...
Aromatic polyketides are an important class of natural products with various bioactivities, and their structural diversity arises from modifications to aromatic frameworks. In this study, we identify a stereoselective aromatase/cyclase (ARO/CYC) FasU, which is responsible for forming the axial chiral biphenyl framework in fasamycin. FasU catalyzes sequential decarboxylation cyclization/aromatization strict S-stereospecificity on previously unidentified biosynthetic intermediate. Through...
Background Alcoholic liver disease (ALD) is a common condition caused by long-term alcohol consumption, and its specific molecular mechanism remains unclear. It may be influenced to some extent ferroptosis Porphyromonas gingivalis ( P.g ), which an important pathogen of periodontitis. Materials methods C57BL/6 J mice AML12 cells were selected as the study subjects. The periodontitis model was induced using , alcoholic created. Pathological analysis performed on liver, intestine, periodontal...
SUMMARY COP1 is a critical repressor of plant photomorphogenesis in darkness. However, plays distinct roles the photoreceptor UVR8 pathway Arabidopsis thaliana . interacts with ultraviolet B (UV‐B)‐activated monomers and promotes their retention accumulation nucleus. Moreover, has function UV‐B signaling, which involves binding its WD40 domain to HY5 via conserved Val‐Pro (VP) motifs these proteins. UV‐B‐activated both core VP motif, leading displacement from stabilization. it remains...
Abstract Background Immune checkpoint inhibitors (ICIs) can improve survivals of metastatic triple negative breast cancer (mTNBC); however, we still seek circulating blood biomarkers to predict the efficacy ICIs. Materials and methods In this study, analyzed data ICIs treated mTNBC collected in Anhui Medical University affiliated hospitals from 2018 2023. The counts lymphocytes, monocytes, platelets, ratio indexes (NLR, MLR, PLR) peripheral were investigated via Kaplan-Meier curves Cox...
Abstract ( S )‐ N ‐Boc‐3‐hydroxypiperidine [( )‐NBHP] is a key intermediate for the synthesis of mantle cell lymphoma drug, ibrutinib. Here, Kp ADH, an alcohol dehydrogenase from Kluyveromyces polyspora , exhibits evolutionary potential in asymmetric reduction ‐Boc‐3‐piperidone (NBPO) to )‐NBHP. By screening residues substrate binding pocket excellent variant Y127W was obtained with 6‐fold improved activity 119.3 U mg −1 1.8‐fold enhanced half‐life 147 h and strict ‐stereoselectivity...
Background: Alcohol-associated liver disease (ALD) is a major health care challenge worldwide with limited therapeutic options. Although mesenchymal stem/stromal cells (MSCs) represent newly emerging approach to treat ALD, thus far, there have been extensive efforts try and enhance their efficacy, including genetically engineering MSCs. FGF21, an endocrine stress-responsive hormone, has shown regulate energy balance, glucose, lipid metabolism the homing of MSCs toward injured sites....
Cofactor regeneration using diols as "smart cosubstrates" is one of the most promising approaches, due to thermodynamic preference and 0.5-equiv requirement. In order establish an efficient NADPH system with 1,4-butanediol (1,4-BD), a NADP+-dependent alcohol dehydrogenase from Kluyveromyces polysporus (KpADH) was engineered solve kinetic imbalance. Several hotspots were identified through molecular dynamic simulation subjected saturation combinatorial mutagenesis. Variant KpADHV84I/Y127M...
Gametogenesis is an essential step for malaria parasite transmission and activated in mosquito by signals including temperature drop, pH change, mosquito-derived xanthurenic acid (XA). Recently, a membrane protein gametogenesis 1 (GEP1) was found to be responsible sensing these interacting with giant guanylate cyclase α (GCα) activate the cGMP-PKG-Ca2+ signaling pathway gametogenesis. However, molecular mechanisms this process remain unclear. In study, we used AlphaFold2 predict structure of...
Currently there are increasing interests in using REST architecture style to implement business process. However, the importance of role is not emphasized. In fact critical determine RESTful services description and control composition. This paper presents a role-centric composition mechanism Firstly resource meta-model proposed, then process formally defined, generated based on BPEL extended by introducing concept access resources. A case study also given illustrate approach desirable...
All existing Web service composition standards remain at the descriptive level, without providing any formal semantics and method for verifying some important properties. choreography interface (WSCI) describes flow of messages exchanged by a which participates in choreographed interactions with other services. This paper presents an extended Petri net to formalize WSCI, proposes several nets represent activity, process respectively. Our model remarkably focuses on message exchange context...
We first discuss the semantic heterogeneity problem of interaction in large scale MAS. Based on agent society theory, we introduce a grouping method to decompose MAS by different domain or concept, and propose an ontology mapping mechanism resolve problem. In environment, both inter-society intra-society method, finally architecture prototype system for society. also use user participation improve our quality. Our research is based mainly focusing interoperability between societies analysis,...
<title>Abstract</title> BACKGROUND Alcoholic liver disease (ALD) is a common caused by long-term alcohol consumption, the specific molecular mechanism of which still unclear. It may be influenced to some extent ferroptosis and <italic>P.g</italic>, an important pathogen periodontitis. MARERIALS AND METHODS: C57BL/6 mice AML12 cells were selected as study subjects. The periodontitis model was induced <italic>P.g</italic> alcoholic created. Pathological analysis performed on liver, intestine...
Abstract Background Breast cancer is the leading cause of death in female population worldwide. The mainstay treatment for breast includes chemotherapy, targeted therapy, endocrine therapy and immunotherapy. Tissue factor pathway inhibitor 2 (TFPI2) plays an important role balancing activity various enzymes human environment. However, correlation TFPI2 to prognosis immune infiltration has not been reported. Methods We firstly analyzed expression level via high-throughput sequencing, clinical...